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Hideaki Oikawa

Hideaki Oikawa

D-Index & Metrics

Chemistry

D-Index
59
Citations
11714
World Ranking
10198
National Ranking
732

Overview

Hideaki Oikawa is affiliated with Hokkaido University in Japan and works in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research covers several subfields including Pharmacology, Molecular Biology, Organic Chemistry, Biotechnology, and Materials Chemistry.

The scientist has concentrated research efforts on topics such as:

  • Microbial Natural Products and Biosynthesis
  • Plant biochemistry and biosynthesis
  • Fungal Biology and Applications
  • Alkaloids: synthesis and pharmacology
  • Marine Sponges and Natural Products
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Hideaki Oikawa has published extensively, including recent papers such as:

  • FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis, 2020, Nature Chemistry
  • Fungal-derived brevianamide assembly by a stereoselective semipinacolase, 2020, Nature Catalysis
  • Total synthesis of alkaloids using both chemical and biochemical methods, 2020, Natural Product Reports
  • Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases, 2021, Organic Letters
  • Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes, 2020, Scientific Reports

They frequently publish in a select group of journals, including:

  • Angewandte Chemie International Edition
  • Organic Letters
  • Bioscience Biotechnology and Biochemistry
  • Angewandte Chemie
  • The Cambridge Structural Database

Oikawa has collaborated with co-authors who have contributed substantially to their research output. Prominent frequent co-authors include:

  • Atsushi Minami
  • Taro Ozaki
  • Chengwei Liu
  • Junya Takino
  • Jun-ichi Maruyama

Best Publications

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

    Mamoru Komatsu;Muneya Tsuda;Satoshi Omura;Hideaki Oikawa

  • Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products.

    Hideaki Oikawa;Tetsuo Tokiwano

  • Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

    Kenji Watanabe;Kinya Hotta;Alex P Praseuth;Kento Koketsu

  • Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase.

    Toyoyuki Ose;Kenji Watanabe;Takashi Mie;Mamoru Honma

  • Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.

    Kazuko Otomo;Hiromichi Kenmoku;Hideaki Oikawa;Wilfried A. König

  • Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

    Haruki Mizoguchi;Hideaki Oikawa;Hiroki Oguri;Hiroki Oguri

  • Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.

    Koichi Tagami;Chengwei Liu;Atsushi Minami;Motoyoshi Noike

  • Identification of Ophiobolin F Synthase by a Genome Mining Approach: A Sesterterpene Synthase from Aspergillus clavatus

    Ryota Chiba;Atsushi Minami;Katsuya Gomi;Hideaki Oikawa

  • Solanapyrone Synthase, a Possible Diels–Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani

    Ken Kasahara;Ken Kasahara;Takanori Miyamoto;Takashi Fujimoto;Hiroki Oguri

  • Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes

    Ying Ye;Atsushi Minami;Attila Mandi;Chengwei Liu

  • Diterpene Cyclases Responsible for the Biosynthesis of Phytoalexins, Momilactones A, B, and Oryzalexins A–F in Rice

    Kazuko Otomo;Yuri Kanno;Akihiro Motegi;Hiromichi Kenmoku

  • Molecular cloning and characterization of a cDNA encoding ent‐cassa‐12,15‐diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension‐cultured rice cells treated with a chitin elicitor

    Eun-Min Cho;Atsushi Okada;Hiromichi Kenmoku;Kazuko Otomo

  • Enzymatic activity catalysing exo-selective Diels–Alder reaction in solanapyrone biosynthesis

    Hideaki Oikawa;Kinya Katayama;Yuichi Suzuki;Akitami Ichihara

  • Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.

    Shinya Mitsuhashi;Nobuyasu Matsuura;Makoto Ubukata;Hideaki Oikawa

  • Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants.

    Atsushi Minami;Taro Ozaki;Chengwei Liu;Hideaki Oikawa

  • Characterization and thermal degradation of polyimide and polyamide liquid crystalline polymers

    K.P. Pramoda;T.S. Chung;S.L. Liu;H. Oikawa

  • FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis.

    Lei Gao;Lei Gao;Cong Su;Xiaoxia Du;Ruishan Wang

  • An Iterative Type I Polyketide Synthase PKSN Catalyzes Synthesis of the Decaketide Alternapyrone with Regio-Specific Octa-Methylation

    Isao Fujii;Naho Yoshida;Shigeki Shimomaki;Hideaki Oikawa

  • Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

    Kento Koketsu;Kenji Watanabe;Haruna Suda;Hiroki Oguri

  • Total Synthesis of (−)-Solanapyrone A via Enzymatic Diels−Alder Reaction of Prosolanapyrone

    Hideaki Oikawa;Tomonori Kobayashi;Kinya Katayama;Yuichi Suzuki

  • Recent advances of Diels–Alderases involved in natural product biosynthesis

    Atsushi Minami;Hideaki Oikawa

Frequent Co-Authors

Katsuya Gomi
Katsuya Gomi Tohoku University
Tohru Dairi
Tohru Dairi Hokkaido University
Yutaka Ebizuka
Yutaka Ebizuka University of Tokyo
Isao Tanaka
Isao Tanaka Hokkaido University
Min Yao
Min Yao Hokkaido University
Clay C. C. Wang
Clay C. C. Wang University of Southern California
Hisakazu Yamane
Hisakazu Yamane Teikyo University
Satoshi Omura
Satoshi Omura Kitasato University
Jens Christian Frisvad
Jens Christian Frisvad Technical University of Denmark
Robert S. Paton
Robert S. Paton Colorado State University

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