His main research concerns Fibronectin, Cell biology, Integrin, Molecular biology and Laminin. The study incorporates disciplines such as Alternative splicing, Binding site and Precursor mRNA in addition to Fibronectin. Kiyotoshi Sekiguchi interconnects Receptor, Angiogenesis and Induced pluripotent stem cell in the investigation of issues within Cell biology.
His study looks at the relationship between Integrin and fields such as Cell migration, as well as how they intersect with chemical problems. His studies deal with areas such as Immunohistochemistry, Cell adhesion and Focal adhesion as well as Molecular biology. Kiyotoshi Sekiguchi combines subjects such as Internal medicine, Endocrinology and Basement membrane with his study of Laminin.
His primary scientific interests are in Cell biology, Laminin, Molecular biology, Integrin and Fibronectin. His Cell biology research integrates issues from Cell and Induced pluripotent stem cell. His work is dedicated to discovering how Laminin, Pathology are connected with Adenocarcinoma and Cancer research and other disciplines.
His work investigates the relationship between Molecular biology and topics such as Transcription factor that intersect with problems in Endoderm. His biological study spans a wide range of topics, including Integrin alpha M, Cell migration and Cell adhesion. His studies in Fibronectin integrate themes in fields like Binding site and Alternative splicing.
Kiyotoshi Sekiguchi spends much of his time researching Cell biology, Laminin, Integrin, Induced pluripotent stem cell and Pathology. His Cell biology research is multidisciplinary, incorporating elements of Cell and Cellular differentiation. Laminin is a subfield of Extracellular matrix that he tackles.
His research integrates issues of Type IV collagen, In vitro, Endoderm and In vivo in his study of Integrin. His study in Pathology is interdisciplinary in nature, drawing from both Muscular dystrophy and Dermal papillae. His A protein research is multidisciplinary, incorporating perspectives in Molecular biology and Cell culture.
His scientific interests lie mostly in Laminin, Cell biology, Stem cell, Induced pluripotent stem cell and Extracellular matrix. His Laminin study integrates concerns from other disciplines, such as Cell culture, Integrin, Integrin binding, Biophysics and Transplantation. His research investigates the connection between Cell culture and topics such as A protein that intersect with issues in Molecular biology.
His Integrin research is multidisciplinary, relying on both In vitro and In vivo. His study of Function is a part of Cell biology. In his study, Angiogenesis and Autoantibody is inextricably linked to Pathology, which falls within the broad field of Extracellular matrix.
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Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins.
Y. Kikkawa;N. Sanzen;H. Fujiwara;A. Sonnenberg.
Journal of Cell Science (2000)
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
Kotaro Sasaki;Shihori Yokobayashi;Tomonori Nakamura;Ikuhiro Okamoto.
Cell Stem Cell (2015)
Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment
Ri-ichiroh Manabe;Naoko Oh-e;Toshinaga Maeda;Tomohiko Fukuda.
Journal of Cell Biology (1997)
Laminin-10/11 and Fibronectin Differentially Regulate Integrin- dependent Rho and Rac Activation via p130Cas-CrkII-DOCK180 Pathway
Jianguo Gu;Yasuhiro Sumida;Noriko Sanzen;Kiyotoshi Sekiguchi.
Journal of Biological Chemistry (2001)
Isolation and Characterization of Laminin-10/11 Secreted by Human Lung Carcinoma Cells : LAMININ-10/11 MEDIATES CELL ADHESION THROUGH INTEGRIN α3β1
Yamato Kikkawa;Noriko Sanzen;Kiyotoshi Sekiguchi.
Journal of Biological Chemistry (1998)
Integrin α3β1‐mediated interaction with laminin‐5 stimulates adhesion, migration and invasion of malignant glioma cells
Yuji Fukushima;Takanori Ohnishi;Norio Arita;Toru Hayakawa.
International Journal of Cancer (1998)
Introduction of Bisecting GlcNAc into Integrin α5β1 Reduces Ligand Binding and Down-regulates Cell Adhesion and Cell Migration
Tomoya Isaji;Jianguo Gu;Ryoko Nishiuchi;Yanyang Zhao.
Journal of Biological Chemistry (2004)
Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries.
Judith M. Healy;Ohoshi Murayama;Toshinaga Maeda;Kazuhiro Yoshino.
Purification and Characterization of Human Laminin-8 LAMININ-8 STIMULATES CELL ADHESION AND MIGRATION THROUGH α3β1 AND α6β1INTEGRINS
Hironobu Fujiwara;Yamato Kikkawa;Noriko Sanzen;Kiyotoshi Sekiguchi.
Journal of Biological Chemistry (2001)
Domain structure of human plasma fibronectin. Differences and similarities between human and hamster fibronectins.
Kiyotoshi Sekiguchi;Sen-itiroh Hakomori.
Journal of Biological Chemistry (1983)
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