World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
49
Citations
9585
World Ranking
14737
National Ranking
1081

Overview

Herbert Nar is affiliated with Boehringer Ingelheim in Germany and has contributed to research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans a range of subfields including Molecular Biology, Oncology, Endocrinology, Diabetes and Metabolism, Cellular and Molecular Neuroscience, and Immunology.

Their research topics cover several key areas such as:

  • Receptor Mechanisms and Signaling
  • Diabetes Treatment and Management
  • Neuropeptides and Animal Physiology
  • Peptidase Inhibition and Analysis
  • CAR-T cell therapy research
  • Metabolism, Diabetes, and Cancer
  • Drug Transport and Resistance Mechanisms

Herbert Nar has been involved in publishing in several recurrent venues, including:

  • Proceedings of the National Academy of Sciences
  • Journal of Medicinal Chemistry
  • ChemMedChem
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature

Their recent papers showcase a focus on structural biology, protein function inhibition, and drug discovery. Key publications include:

  • "Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter," 2021, Nature
  • "Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis," 2020, Proceedings of the National Academy of Sciences
  • "A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state," 2020, Communications Chemistry
  • "Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51," 2020, Journal of Medicinal Chemistry
  • "Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain," 2021, Journal of Medicinal Chemistry

Frequent collaborators in their work include Rebecca Ebenhoch, Gisela Schnapp, Margit Bauer, Markus Zeeb, and Dietmar Weichert. These coauthors have contributed to multiple joint publications reflecting a sustained collaborative network.

Best Publications

  • A specific antidote for dabigatran: functional and structural characterization.

    Felix Schiele;Joanne van Ryn;Keith Canada;Corey Newsome

  • Structure-based design of novel potent nonpeptide thrombin inhibitors.

    Norbert H Hauel;Herbert Nar;Henning Priepke;Uwe Ries

  • Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.

    H Nar;A Messerschmidt;R Huber;M van de Kamp

  • 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.

    Matthias Eckhardt;Elke Langkopf;Michael Mark;Moh Tadayyon

  • Biophysics in drug discovery: impact, challenges and opportunities

    Jean-Paul Renaud;Chun-wa Chung;U. Helena Danielson;Ursula Egner

  • Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.

    Youla S. Tsantrizos;Gordon Bolger;Pierre Bonneau;Dale R. Cameron

  • Structural basis for photo-induced protein cleavage and green-to-red conversion of fluorescent protein EosFP

    K. Nienhaus;G.U. Nienhaus;J. Wiedenmann;H. Nar

  • Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

    Laetitia J. Martin;Manfred Koegl;Gerd Bader;Xiao-Ling Cockcroft

  • X-ray analysis and spectroscopic characterization of M121Q azurin. A copper site model for stellacyanin

    Antonio Romero;Carla W.G. Hoitink;Herbert Nar;Robert Huber

  • X-ray crystal structure of the two site-specific mutants His35Gln and His35Leu of azurin from Pseudomonas aeruginosa.

    H. Nar;A. Messerschmidt;R. Huber;M. van de Kamp

  • Characterization and crystal structure of zinc azurin, a by-product of heterologous expression in Escherichia coli of Pseudomonas aeruginosa copper azurin.

    Herbert Nar;Robert Huber;Albrecht Messerschmidt;Alexander C. Filippou

  • Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.

    Joerg F. Rippmann;Silke Hobbie;Christine Daiber;Bernd Guilliard

  • Atomic Structure of GTP Cyclohydrolase I

    Herbert Nar;Robert Huber;Winfried Meining;Cornelia Schmid

  • Crystal structure of Pseudomonas aeruginosa apo-azurin at 1.85 A resolution.

    Herbert Nar;Albrecht Messerschmidt;Robert Huber;Mart van de Kamp

  • Zinc plays a key role in human and bacterial GTP cyclohydrolase I

    Günter Auerbach;Anja Herrmann;Andreas Bracher;Gerd Bader

  • Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications.

    G. Ulrich Nienhaus;G. Ulrich Nienhaus;Karin Nienhaus;Angela Hölzle;Sergey Ivanchenko

  • Active site topology and reaction mechanism of GTP cyclohydrolase I

    Herbert Nar;Robert Huber;Gunter Auerbach;Markus Fischer

  • Repaglinide and related hypoglycemic benzoic acid derivatives.

    Wolfgang Grell;Rudolf Hurnaus;Gerhart Griss;Robert Sauter

  • Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.

    Herbert Nar;Margit Bauer;Jean-Marie Stassen;Dietmar Lang

  • One Target—Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1β

    Michaela Blech;Daniel Peter;Peter Fischer;Margit M.T. Bauer

  • Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.

    Herbert Nar;Margit Bauer;Angela Schmid;Jean-Marie Stassen

Frequent Co-Authors

Robert Huber
Robert Huber University of Duisburg-Essen
Frank Himmelsbach
Frank Himmelsbach Boehringer Ingelheim (Germany)
Matthias Eckhardt
Matthias Eckhardt Boehringer Ingelheim (Germany)
Albrecht Messerschmidt
Albrecht Messerschmidt Max Planck Society
Gerard W. Canters
Gerard W. Canters Leiden University
Robert Huber
Robert Huber Agricultural & Applied Economics Association
Wenjun Tang
Wenjun Tang Chinese Academy of Sciences
Chris H. Senanayake
Chris H. Senanayake TCG GreenChem Inc.
Beat Thöny
Beat Thöny University of Zurich
Jörg Wiedenmann
Jörg Wiedenmann University of Southampton

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens doors to diverse career paths, many of which can be pursued through specialized online degrees. For those interested in healthcare, understanding how to become a pharmacist offers a valuable roadmap to entering a respected and well-compensated profession. Pharmacists play a crucial role in medication management and patient care.

Another unique path is in forensic science, where a degree can lead to important roles in criminal investigations. If you’re wondering about how much do autopsy techs make, it shows the practical benefits of combining chemistry knowledge with forensic skills. This career demands precision and analytical expertise — qualities nurtured through dedicated study.

For those interested in flexible educational options, exploring forensic science degree online programs allows students to build credentials without compromising their schedules. Likewise, earning a master's in forensic psychology online offers an interdisciplinary approach, blending chemistry, psychology, and law to prepare for specialized investigative careers.

These varied online degree options highlight the dynamic opportunities available after studying chemistry, enabling a seamless transition into careers that impact healthcare, law enforcement, and beyond.

Best Scientists Citing Herbert Nar

Trending Scientists