World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
34012
World Ranking
2087
National Ranking
1138

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kun Ping Lu is affiliated with the Beth Israel Deaconess Medical Center in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, oncology, immunology, neurology, and pulmonary and respiratory medicine.

The scientist's work is strongly focused on disease-related signaling pathways, peptidase inhibition and analysis, toxin mechanisms and immunotoxins, neuroinflammation and neurodegeneration mechanisms, nerve injury and regeneration, cancer-related cognitive impairment studies, and wireless signal modulation classification.

Key recent publications by Kun Ping Lu include the following:

  • "Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy" (2021, Cell)
  • "Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo" (2021, Nature Chemical Biology)
  • "Rethinking Modern Communication from Semantic Coding to Semantic Communication" (2022, IEEE Wireless Communications)
  • "Identification of a potent and selective covalent Pin1 inhibitor" (2020, Nature Chemical Biology)
  • "Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice" (2021, Science Translational Medicine)

Frequent coauthors in their research include Xiao Zhen Zhou, Chenxi Qiu, Nathanael S. Gray, Min Zheng, and Kazuhiro Koikawa.

Kun Ping Lu has published multiple papers in journals such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Nature Chemical Biology, Journal of Hazardous Materials, and Cancer Letters.

Their fields of study indicate a strong multidisciplinary approach, integrating molecular biology techniques with oncology and immunology research to explore signaling pathways and mechanisms underlying various diseases, including cancer and neurodegenerative conditions.

Kun Ping Lu was awarded the status of Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • A human peptidyl-prolyl isomerase essential for regulation of mitosis

    Kun Ping Lu;Steven D. Hanes;Tony Hunter

  • Sequence-specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism

    Michael B. Yaffe;Mike Schutkowski;Minhui Shen;Xiao Zhen Zhou

  • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

    Pei Jung Lu;Gerburg Wulf;Xiao Zhen Zhou;Peter Davies

  • Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent

    Rama Ranganathan;Kun Ping Lu;Kun Ping Lu;Tony Hunter;Joseph P. Noel

  • Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

    Pei Jung Lu;Xiao Zhen Zhou;Minhui Shen;Kun Ping Lu

  • Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA

    Akihide Ryo;Futoshi Suizu;Yasuhiro Yoshida;Kilian Perrem

  • A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

    Z. Songyang;Kun Ping Lu;Young T. Kwon;Li Huei Tsai

  • The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

    Kun Ping Lu;Xiao Zhen Zhou

  • Regulation of Raf-1 by Direct Feedback Phosphorylation

    Michele K. Dougherty;Jürgen Müller;Daniel A. Ritt;Ming Zhou

  • Prolyl cis-trans isomerization as a molecular timer

    Kun Ping Lu;Greg Finn;Tae Ho Lee;Linda K Nicholson

  • Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.

    Xiao Zhen Zhou;Oliver Kops;Andreas Werner;Pei Jung Lu

  • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1

    Gerburg M. Wulf;Akihide Ryo;Gerald G. Wulf;Sam W. Lee

  • Structural basis for phosphoserine-proline recognition by group IV WW domains.

    Mark A. Verdecia;Marianne E. Bowman;Kun Ping Lu;Tony Hunter

  • Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC

    Akihide Ryo;Masafumi Nakamura;Gerburg Wulf;Yih Cherng Liou

  • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

    Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou

  • Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

    Yih-Cherng Liou;Anyang Sun;Anyang Sun;Akihide Ryo;Akihide Ryo;Xiao Zhen Zhou

  • Prevalent overexpression of prolyl isomerase Pin1 in human cancers.

    Lere Bao;Amy Kimzey;Guido Sauter;Janusz M. Sowadski

  • The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

    Hongwu Zheng;Han You;Xiao Zhen Zhou;Stephen A. Murray

  • Pinning down proline-directed phosphorylation signaling.

    Kun Ping Lu;Yih Cherng Liou;Xiao Zhen Zhou

  • The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

    Minhui Shen;P. T. Stukenberg;M. W. Kirschner;Kun Ping Lu

Frequent Co-Authors

Xiao Zhen Zhou
Xiao Zhen Zhou Beth Israel Deaconess Medical Center
Gerburg M. Wulf
Gerburg M. Wulf Beth Israel Deaconess Medical Center
Akihide Ryo
Akihide Ryo Yokohama City University
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Ruey-Hwa Chen
Ruey-Hwa Chen Academia Sinica
Nathanael S. Gray
Nathanael S. Gray Stanford University
Sam W. Lee
Sam W. Lee Broad Institute
Jarrod A. Marto
Jarrod A. Marto Harvard University
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University
Ann C. McKee
Ann C. McKee Boston University

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