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Biology and Biochemistry

D-Index
78
Citations
33901
World Ranking
4445
National Ranking
2160

Overview

Sam W. Lee is affiliated with the Broad Institute in the United States and specializes in the field of Immunology and Microbiology. Their research focuses particularly on immunology, oncology, pathology and forensic medicine, molecular biology, and pharmacology. The scientist's work covers several interconnected domains within these fields.

The primary topics explored by Sam W. Lee include:

  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Cancer Mechanisms and Therapy
  • CRISPR and Genetic Engineering

Recent publications demonstrate a focus on immune regulation, cancer biology, and immune checkpoints. Notable papers include:

  • "VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance," published in 2020 in Science
  • "Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells," published in 2020 in Science Advances
  • "Clinical and research updates on the VISTA immune checkpoint: immuno-oncology themes and highlights," published in 2023 in Frontiers in Oncology
  • "VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology," published in 2021 in Acta Neuropathologica Communications
  • "RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress," published in 2020 in UNC Libraries

Sam W. Lee frequently collaborates with colleagues across multiple projects. Their most frequent co-authors include:

  • Randolph J. Noelle
  • Elizabeth C. Nowak
  • J. Louise Lines
  • Malte Borggrewe
  • Susanne M. Kooistra

Publication venues where Sam W. Lee's work has appeared include:

  • Science
  • Frontiers in Oncology
  • Science Advances
  • Acta Neuropathologica Communications
  • UNC Libraries

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

    Lakshmi Raj;Takao Ide;Aditi U. Gurkar;Michael Foley

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1

    Gerburg M. Wulf;Akihide Ryo;Gerald G. Wulf;Sam W. Lee

  • Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

    Sam W Lee;Corinne L Reimer;Phil Oh;Doreen B Campbell

  • Positive selection of candidate tumor-suppressor genes by subtractive hybridization.

    Sam W. Lee;Catherine Tomasetto;Ruth Sager

  • Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.

    Salvador Macip;Makoto Igarashi;Li Fang;Angus Chen

  • Influence of induced reactive oxygen species in p53-mediated cell fate decisions.

    Salvador Macip;Makoto Igarashi;Petra Berggren;Jian Yu

  • Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

    Mary M. Sugrue;Deug Y. Shin;Sam W. Lee;Stuart A. Aaronson

  • A small molecule that binds Hedgehog and blocks its signaling in human cells

    Benjamin Z Stanton;Lee F Peng;Lee F Peng;Nicole Maloof;Kazuo Nakai

  • Inhibition of Tumor Cell Growth by RTP/rit42 and Its Responsiveness to p53 and DNA Damage

    Siavash K. Kurdistani;Paz Arizti;Corinne L. Reimer;Mary M. Sugrue

  • PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

    Akihide Ryo;Yih Cherng Liou;Gerburg Wulf;Masafumi Nakamura

  • Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.

    S. W. Lee;C. Tomasetto;D. Paul;Khandan Keyomarsi

  • Emerging roles of p53 and other tumour-suppressor genes in immune regulation

    César Muñoz-Fontela;Anna Mandinova;Stuart A. Aaronson;Sam W. Lee;Sam W. Lee

  • Role of Pin1 in the Regulation of p53 Stability and p21 Transactivation, and Cell Cycle Checkpoints in Response to DNA Damage

    Gerburg M. Wulf;Yih-Cherng Liou;Akihide Ryo;Sam W. Lee

  • H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer.

    Sam W. Lee

  • p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53.

    Li Fang;Makoto Igarashi;Jennifer Leung;Mary M Sugrue

  • BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition

    Mutsuko Ouchi;Nobuko Fujiuchi;Kaori Sasai;Hiroshi Katayama

  • Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes

    Toru Ouchi;Sam W. Lee;Mutsuko Ouchi;Stuart A. Aaronson

Frequent Co-Authors

Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Akihide Ryo
Akihide Ryo Yokohama City University
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Evelina Gatti
Evelina Gatti Aix-Marseille University
Nektarios Tavernarakis
Nektarios Tavernarakis Foundation for Research and Technology Hellas
Wafik S. El-Deiry
Wafik S. El-Deiry Brown University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Ruth Sager
Ruth Sager Harvard University
Simone Fulda
Simone Fulda Goethe University Frankfurt

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