His primary scientific interests are in Genetics, Parkinsonism, LRRK2, Parkinson's disease and Mutation. Many of his studies involve connections with topics such as Disease and Genetics. His work carried out in the field of Disease brings together such families of science as Pathological, Neuroscience and Gene.
His study on Parkinsonism is covered under Pathology. His research integrates issues of Bioinformatics, Allele frequency and Risk factor in his study of LRRK2. His Mutation course of study focuses on Parkin and Ubiquitin ligase.
His main research concerns Genetics, Parkinson's disease, Parkinsonism, Disease and LRRK2. His is involved in several facets of Genetics study, as is seen by his studies on Mutation, Gene, Haplotype, Locus and Allele. His work deals with themes such as Endocrinology, Case-control study and Allele frequency, which intersect with Parkinson's disease.
His research in Parkinsonism focuses on subjects like Parkin, which are connected to Compound heterozygosity. His Disease study incorporates themes from Phenotype, Pathological, Neuroscience and Bioinformatics. His LRRK2 study combines topics from a wide range of disciplines, such as Penetrance and Kinase.
His primary areas of investigation include Parkinson's disease, Parkinsonism, Genetics, Disease and LRRK2. His Parkinson's disease research is multidisciplinary, incorporating elements of Dopaminergic, Allele, Genetic predisposition and Pathogenesis. His Parkinsonism study improves the overall literature in Pathology.
The study incorporates disciplines such as Phenotype, Psychiatry, Neuroscience and Cohort in addition to Disease. His LRRK2 study integrates concerns from other disciplines, such as Penetrance, Risk factor, Vacuolar protein sorting and Cell biology. His Alpha-synuclein research focuses on Kinase and how it relates to Synuclein.
Matthew J. Farrer spends much of his time researching Parkinsonism, Genetics, Parkinson's disease, Internal medicine and Disease. His Parkinsonism study introduces a deeper knowledge of Pathology. His study in Mutation, Proband, Genetic heterogeneity and Haplotype falls under the purview of Genetics.
As part of one scientific family, Matthew J. Farrer deals mainly with the area of Parkinson's disease, narrowing it down to issues related to the VPS35, and often Cell biology. Matthew J. Farrer combines subjects such as Endocrinology and Oncology with his study of Internal medicine. His Disease research includes themes of Biomarker, Phenotype, Odds ratio and Bioinformatics.
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α-Synuclein Locus Triplication Causes Parkinson's Disease
A. B. Singleton;M. Farrer;J. Johnson;A. Singleton.
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich;Alexander Zimprich;Saskia Biskup;Petra Leitner;Peter Lichtner.
α-synuclein locus duplication as a cause of familial Parkinson's disease
Marie-Christine Chartier-Harlin;Jennifer M. Kachergus;Christophe Roumier;Vincent Mouroux.
The Lancet (2004)
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Ellen Sidransky;Michael A. Nalls;Jan O. Aasly;Judith Aharon-Peretz.
The New England Journal of Medicine (2009)
Genetics of Parkinson disease: paradigm shifts and future prospects.
Matthew James Farrer.
Nature Reviews Genetics (2006)
Missing pieces in the Parkinson's disease puzzle.
Jose A Obeso;Maria C Rodriguez-Oroz;Christopher G Goetz;Concepcion Marin;Concepcion Marin.
Nature Medicine (2010)
VPS35 Mutations in Parkinson Disease
Carles Vilariño-Güell;Christian Wider;Owen A. Ross;Justus C. Dachsel.
American Journal of Human Genetics (2011)
Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications
Matt Farrer;Jennifer Kachergus;Lysia Forno;Sarah Lincoln.
Annals of Neurology (2004)
Parkin Protects against the Toxicity Associated with Mutant α-Synuclein: Proteasome Dysfunction Selectively Affects Catecholaminergic Neurons
Leonard Petrucelli;Casey O'Farrell;Paul J. Lockhart;Melisa Baptista.
α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
Natalie Ostrerova;Leonard Petrucelli;Matthew Farrer;Nitinkumar Mehta.
The Journal of Neuroscience (1999)
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