World's Best Scientists 2026 revealed!
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Genetics
USA
2026

D-Index & Metrics

Genetics

D-Index
156
Citations
126495
World Ranking
113
National Ranking
57

Medicine

D-Index
160
Citations
135448
World Ranking
765
National Ranking
433

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award

Overview

Andrew B. Singleton is affiliated with the National Institutes of Health in the United States. Their research primarily spans across medicine, biochemistry, genetics, molecular biology, and neuroscience, with a strong focus on neurology and molecular biology as subfields. Singleton's work addresses topics such as Parkinson's disease mechanisms and treatments, neurological diseases and metabolism, RNA regulation and disease, genetic associations and epidemiology, lysosomal storage disorders research, nuclear receptors and signaling, and autism spectrum disorder research.

Several papers authored or co-authored by Singleton illustrate the scope and depth of their research. These include:

  • A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research (2024) published in The Lancet Neurology
  • Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis (2021) published in Nature Neuroscience
  • Genetics of Parkinson's disease: An introspection of its journey towards precision medicine (2020) published in Neurobiology of Disease
  • Virus exposure and neurodegenerative disease risk across national biobanks (2023) published in Neuron
  • A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states (2022) published in Nature Neuroscience

Singleton frequently collaborates with a number of researchers, including:

  • Cornelis Blauwendraat
  • Mike A. Nalls
  • Sara Bandrés-Ciga
  • Hirotaka Iwaki
  • Hampton L. Leonard

The scientist has a consistent publication record in several venues notable for neuroscience and neurology research. Key venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • npj Parkinson s Disease
  • UNC Libraries
  • Neurology

Andrew B. Singleton's research contributions cover a range of complex biological and neurological systems, with Parkinson's disease being a recurring focal point. Their work combines genetic, molecular, and cellular approaches to better understand neurodegenerative diseases and their underlying molecular mechanisms.

Best Publications

  • α-Synuclein Locus Triplication Causes Parkinson's Disease

    A. B. Singleton;M. Farrer;J. Johnson;A. Singleton

  • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

    Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez

  • Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

    Ian G. McKeith;Bradley F. Boeve;Dennis W. DIckson;Glenda Halliday

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

    Coro Paisán-Ruı́z;Shushant Jain;E.Whitney Evans;William P. Gilks

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Josée Dupuis;Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena;Richa Saxena

  • Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

    Ellen Sidransky;Michael A. Nalls;Jan O. Aasly;Judith Aharon-Peretz

  • Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

    Mike A Nalls;Cornelis Blauwendraat;Costanza L Vallerga;Karl Heilbron

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Georg B. Ehret;Georg B. Ehret;Georg B. Ehret;Patricia B. Munroe;Kenneth M. Rice;Murielle Bochud

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Javier Simón-Sánchez;Claudia Schulte;Jose M Bras;Jose M Bras;Manu Sharma

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)

    J Dupuis;C Langenberg;I Prokopenko;R Saxena

  • Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

    Tom Walsh;Jon M. McClellan;Shane E. McCarthy;Anjené M. Addington

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Mike A Nalls;Nathan Pankratz;Christina M. Lill;Chuong B. Do

  • Systematic identification of trans eQTLs as putative drivers of known disease associations

    Harm-Jan Westra;Marjolein J Peters;Tõnu Esko;Hanieh Yaghootkar

  • The Parkinson Progression Marker Initiative (PPMI)

    Kenneth Marek;Danna Jennings;Shirley Lasch;Andrew Siderowf

  • A genome-wide association search for type 2 diabetes genes in African Americans.

    N D Palmer;C W McDonough;P J Hicks;B H Roh

  • Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

    Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena

Frequent Co-Authors

Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
John Hardy
John Hardy University College London
Mike A. Nalls
Mike A. Nalls National Institutes of Health
J. Raphael Gibbs
J. Raphael Gibbs National Institutes of Health
Jose Bras
Jose Bras Van Andel Institute
Rita Guerreiro
Rita Guerreiro Van Andel Institute
Luigi Ferrucci
Luigi Ferrucci National Institutes of Health
Alexis Brice
Alexis Brice Institut du Cerveau
Sonja W. Scholz
Sonja W. Scholz National Institutes of Health
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases

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