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80
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29610
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16951
National Ranking
638

Overview

Peter J. M. Valk is affiliated with Erasmus University Rotterdam in the Netherlands. Their research primarily centers on hematology, with a significant focus on acute myeloid leukemia (AML) and related hematological malignancies. Valk has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology.

Valk's publication record includes a strong emphasis on acute myeloid leukemia research, as shown by key papers such as:

  • "2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party" (2021, Blood)
  • "Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome" (2022, Blood)
  • "Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia" (2020, Science Translational Medicine)
  • "CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome" (2021, Blood)
  • "TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML" (2020, Blood Advances)

These publications reflect involvement in topics such as cancer genomics, diagnostics, chemotherapy resistance, immunotherapy response, and genetic mutations influencing AML outcomes.

Frequent coauthors who have collaborated with Valk include:

  • Bob Löwenberg
  • Gert J. Ossenkoppele
  • François G. Kavelaars
  • Jacqueline Cloos
  • Melissa Rijken

Valk's work has appeared predominantly in these scientific venues:

  • Blood (37 publications)
  • HemaSphere (14 publications)
  • Blood Advances (11 publications)
  • Leukemia (11 publications)
  • Clinical Lymphoma Myeloma & Leukemia (10 publications)

The main fields of study they contribute to encompass:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields reflecting the focus of Valk's research include:

  • Hematology
  • Molecular Biology
  • Genetics
  • Cancer Research
  • Oncology

The principal topics of their work cover:

  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • Chronic Myeloid Leukemia Treatments
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Histone Deacetylase Inhibitors Research
  • Acute Lymphoblastic Leukemia Research
  • Retinoids in leukemia and cellular processes

Best Publications

  • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

    Maria E. Figueroa;Omar Abdel-Wahab;Chao Lu;Patrick S. Ward

  • Prognostically useful gene-expression profiles in acute myeloid leukemia.

    Peter J.M. Valk;Roel G.W. Verhaak;M. Antoinette Beijen;Claudia A.J. Erpelinck

  • DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

    Maria E. Figueroa;Sanne Lugthart;Yushan Li;Claudia Erpelinck-Verschueren

  • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

    Roel G. W. Verhaak;Chantal S. Goudswaard;Wim van Putten;Maarten A. Bijl

  • A 17-gene stemness score for rapid determination of risk in acute leukaemia

    Stanley W. K. Ng;Amanda Mitchell;James A. Kennedy;James A. Kennedy;James A. Kennedy;Weihsu C. Chen

  • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

    Bas J. Wouters;Bob Löwenberg;Claudia A. J. Erpelinck-Verschueren;Wim L. J. van Putten

  • Molecular Minimal Residual Disease in Acute Myeloid Leukemia

    Mojca Jongen-Lavrencic;Tim Grob;Diana Hanekamp;François G Kavelaars

  • A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Stefan Gröschel;Stefan Gröschel;Mathijs A Sanders;Remco Hoogenboezem;Elzo de Wit

  • MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia.

    Mojca Jongen-Lavrencic;Su Ming Sun;Menno K. Dijkstra;Peter J. M. Valk

  • High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study

    Monique Terwijn;Wim L J van Putten;Angèle Kelder;Vincent H J van der Velden

  • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

    Erdogan Taskesen;Lars Bullinger;Andrea Corbacioglu;Mathijs A. Sanders

  • 2021 Update Measurable Residual Disease in Acute Myeloid Leukemia: European LeukemiaNet Working Party Consensus Document.

    Michael Heuser;Sylvie D Freeman;Gert J Ossenkoppele;Francesco Buccisano

  • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.

    Saman Abbas;Sanne Lugthart;François G. Kavelaars;Anita Schelen

  • Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

    Roel G.W. Verhaak;Bas J. Wouters;Claudia A.J. Erpelinck;Saman Abbas

  • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.

    Rory S. Care;Peter J. M. Valk;Anne C. Goodeve;Faisel M. Abu-Duhier

  • Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

    Sheng Li;Francine E Garrett-Bakelman;Stephen S Chung;Mathijs A Sanders

  • High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.

    Sahar Barjesteh van Waalwijk van Doorn-Khosrovani;Claudia Erpelinck;Wim L. J. van Putten;Peter J. M. Valk

  • Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

    Hanno Hock;Eliza Meade;Sarah Medeiros;Jeffrey W. Schindler

  • Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

    Barjesteh van Waalwijk van Doorn-Khosrovani S;Erpelinck C;Meijer J;van Oosterhoud S

  • High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.

    Sanne Lugthart;Ellen van Drunen;Yvette van Norden;Antoinette van Hoven

Frequent Co-Authors

Bob Löwenberg
Bob Löwenberg Erasmus MC
Ruud Delwel
Ruud Delwel Erasmus MC
Konstanze Döhner
Konstanze Döhner University of Ulm
Lars Bullinger
Lars Bullinger Charité - University Medicine Berlin
Ari Melnick
Ari Melnick Cornell University
Jan J. Cornelissen
Jan J. Cornelissen Erasmus University Rotterdam
Gert J. Ossenkoppele
Gert J. Ossenkoppele University of Amsterdam
Arnold Ganser
Arnold Ganser Hannover Medical School
Hartmut Döhner
Hartmut Döhner University of Ulm
H. Berna Beverloo
H. Berna Beverloo Erasmus University Rotterdam

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