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Ruud Delwel

Ruud Delwel

D-Index & Metrics

Medicine

D-Index
73
Citations
24890
World Ranking
19563
National Ranking
713

Overview

Ruud Delwel is affiliated with Erasmus MC in the Netherlands and has an extensive publication record primarily focused on acute myeloid leukemia (AML) and related fields. The scientist has contributed to 44 publications in the domains of Biochemistry, Genetics, and Molecular Biology, as well as 29 publications in Medicine. Their research spans several subfields including Molecular Biology, Hematology, Genetics, Oncology, and Immunology.

The main topics explored by Ruud Delwel include:

  • Acute Myeloid Leukemia Research
  • Protein Degradation and Inhibitors
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Histone Deacetylase Inhibitors Research
  • RNA modifications and cancer
  • RNA Research and Splicing

Frequent publication venues for Delwel's work encompass key journals in hematology and oncology such as Blood, with 11 publications, and others including HemaSphere (3 publications), Cancer Discovery (2 publications), Haematologica (2 publications), and Nature Communications (1 publication).

Selected recent papers authored by or involving Ruud Delwel include:

  • The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops, 2021, Nature Communications
  • Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia, 2020, Blood
  • Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML, 2020, Cancer Discovery
  • BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells, 2020, Blood
  • Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia, 2021, Cancer Discovery

Ruud Delwel has collaborated frequently with several co-authors, including:

  • Roger Mulet-Lazaro (15 collaborations)
  • Marije Havermans (10 collaborations)
  • Leonie Smeenk (9 collaborations)
  • Stanley van Herk (8 collaborations)
  • Eric M. Bindels (7 collaborations)

Best Publications

  • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

    Maria E. Figueroa;Omar Abdel-Wahab;Chao Lu;Patrick S. Ward

  • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Mark A. Dawson;Rab K. Prinjha;Antje Dittmann;George Giotopoulos

  • Prognostically useful gene-expression profiles in acute myeloid leukemia.

    Peter J.M. Valk;Roel G.W. Verhaak;M. Antoinette Beijen;Claudia A.J. Erpelinck

  • DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

    Maria E. Figueroa;Sanne Lugthart;Yushan Li;Claudia Erpelinck-Verschueren

  • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

    Roel G. W. Verhaak;Chantal S. Goudswaard;Wim van Putten;Maarten A. Bijl

  • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

    Bas J. Wouters;Bob Löwenberg;Claudia A. J. Erpelinck-Verschueren;Wim L. J. van Putten

  • A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Stefan Gröschel;Stefan Gröschel;Mathijs A Sanders;Remco Hoogenboezem;Elzo de Wit

  • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

    Erdogan Taskesen;Lars Bullinger;Andrea Corbacioglu;Mathijs A. Sanders

  • Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

    Roel G.W. Verhaak;Bas J. Wouters;Claudia A.J. Erpelinck;Saman Abbas

  • Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

    Sheng Li;Francine E Garrett-Bakelman;Stephen S Chung;Mathijs A Sanders

  • The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

    Su Jung Song;Keisuke Ito;Ugo Ala;Lev Kats

  • High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.

    Sahar Barjesteh van Waalwijk van Doorn-Khosrovani;Claudia Erpelinck;Wim L. J. van Putten;Peter J. M. Valk

  • Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

    Barjesteh van Waalwijk van Doorn-Khosrovani S;Erpelinck C;Meijer J;van Oosterhoud S

  • High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.

    Sanne Lugthart;Ellen van Drunen;Yvette van Norden;Antoinette van Hoven

  • Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

    Ana Flávia Tibúrcio Ribeiro;Ana Flávia Tibúrcio Ribeiro;Marta Pratcorona;Marta Pratcorona;Claudia Erpelinck-Verschueren;Veronika Rockova

  • Mutations in N-ras predominate in acute myeloid leukemia

    J. L. Bos;M. Verlaan-De Vries;A. J. Van Der Eb;J. W. G. Janssen

  • Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

    Altuna Akalin;Francine E. Garrett-Bakelman;Matthias Kormaksson;Jennifer Busuttil

  • High EVI1 Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities

    Stefan Gröschel;Sanne Lugthart;Richard F. Schlenk;Peter J.M. Valk

  • Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia.

    Bas J. Wouters;Ruud Delwel

  • Clinical, Molecular, and Prognostic Significance of WHO Type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and Various Other 3q Abnormalities in Acute Myeloid Leukemia

    Sanne Lugthart;Stefan Gröschel;H. Berna Beverloo;Sabine Kayser

Frequent Co-Authors

Peter J. M. Valk
Peter J. M. Valk Erasmus University Rotterdam
Bob Löwenberg
Bob Löwenberg Erasmus MC
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Ivo P. Touw
Ivo P. Touw Erasmus University Rotterdam
Ari Melnick
Ari Melnick Cornell University
Konstanze Döhner
Konstanze Döhner University of Ulm
Maria E. Figueroa
Maria E. Figueroa University of Miami
Hartmut Döhner
Hartmut Döhner University of Ulm
Lars Bullinger
Lars Bullinger Charité - University Medicine Berlin
H. Berna Beverloo
H. Berna Beverloo Erasmus University Rotterdam

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