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Overview

Lars Bullinger is affiliated with Charité - University Medicine Berlin in Germany. Their research primarily focuses on hematology and related biomedical fields, with a significant concentration on acute myeloid leukemia and molecular biology.

The scientist's main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. They have contributed extensively to subfields such as Hematology, Molecular Biology, Oncology, Genetics, and Immunology.

The central topics of Bullinger's work cover a range of hematologic malignancies and cancer research areas. These topics include:

  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • CAR-T cell therapy research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chronic Lymphocytic Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Protein Degradation and Inhibitors

Some of the frequently publishing venues for Bullinger are specialized journals in hematology and oncology, including:

  • Blood
  • HemaSphere
  • Leukemia
  • Blood Advances
  • Haematologica

Bullinger has collaborated with several co-authors extensively, including:

  • Hartmut Döhner
  • Konstanze Döhner
  • Michael Heuser
  • Anna Dolnik
  • Frédérik Damm

Among their notable recent publications are the following papers:

  • Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia, 2020, Science
  • The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL, 2022, Journal for ImmunoTherapy of Cancer
  • Unified classification and risk-stratification in Acute Myeloid Leukemia, 2022, Nature Communications
  • Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms, 2020, Nature
  • Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin, 2021, Blood

Best Publications

  • Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

    Hartmut Döhner;Stephan Stilgenbauer;Axel Benner;Elke Leupolt

  • Genomic Classification and Prognosis in Acute Myeloid Leukemia

    Elli Papaemmanuil;Moritz Gerstung;Lars Bullinger;Verena I Gaidzik

  • Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

    Richard F. Schlenk;Konstanze Döhner;Jürgen Krauter;Stefan Fröhling

  • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia.

    Lars Bullinger;Konstanze Döhner;Eric Bair;Stefan Fröhling

  • VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia

    Alexander Kröber;Till Seiler;Till Seiler;Axel Benner;Axel Benner;Lars Bullinger;Lars Bullinger

  • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.

    Konstanze Döhner;Richard F Schlenk;Marianne Habdank;Claudia Scholl

  • IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication

    Peter Paschka;Richard F. Schlenk;Verena I. Gaidzik;Marianne Habdank

  • MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

    Kathrin M. Bernt;Nan Zhu;Amit U. Sinha;Sridhar Vempati

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • A 17-gene stemness score for rapid determination of risk in acute leukaemia

    Stanley W. K. Ng;Amanda Mitchell;James A. Kennedy;James A. Kennedy;James A. Kennedy;Weihsu C. Chen

  • Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

    Jan Krönke;Emma C. Fink;Emma C. Fink;Paul W. Hollenbach;Kyle J. MacBeth

  • TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.

    Frank G. Rücker;Richard F. Schlenk;Lars Bullinger;Sabine Kayser

  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

    Claudia Scholl;Stefan Fröhling;Ian F. Dunn;Anna C. Schinzel

  • Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial

    Ulrich Herrlinger;Theophilos Tzaridis;Frederic Mack;Joachim Peter Steinbach

  • Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial

    Stephan Stilgenbauer;Andrea Schnaiter;Peter Paschka;Thorsten Zenz;Thorsten Zenz

  • Genomics of Acute Myeloid Leukemia Diagnosis and Pathways

    Lars Bullinger;Konstanze Döhner;Hartmut Döhner

  • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

    Erdogan Taskesen;Lars Bullinger;Andrea Corbacioglu;Mathijs A. Sanders

  • MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.

    Sandrine Sander;Lars Bullinger;Kay Klapproth;Katja Fiedler

  • Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

    Richard F Schlenk;Sabine Kayser;Lars Bullinger;Guido Kobbe

  • Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

    Michael G Kharas;Michael G Kharas;Christopher J Lengner;Fatima Al-Shahrour;Fatima Al-Shahrour;Lars Bullinger

Frequent Co-Authors

Hartmut Döhner
Hartmut Döhner University of Ulm
Konstanze Döhner
Konstanze Döhner University of Ulm
Richard F. Schlenk
Richard F. Schlenk University Hospital Heidelberg
Arnold Ganser
Arnold Ganser Hannover Medical School
Fatima Al-Shahrour
Fatima Al-Shahrour Spanish National Cancer Research Centre
Jonathan R. Pollack
Jonathan R. Pollack Stanford University
Michael Heuser
Michael Heuser Hannover Medical School
Stephan Stilgenbauer
Stephan Stilgenbauer University of Ulm
Michael Lübbert
Michael Lübbert University of Freiburg
Scott A. Armstrong
Scott A. Armstrong Harvard University

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