World's Best Scientists 2026 revealed!
Scott A. Armstrong

Scott A. Armstrong

D-Index & Metrics

Biology and Biochemistry

D-Index
99
Citations
47479
World Ranking
1562
National Ranking
878

Medicine

D-Index
99
Citations
47548
World Ranking
8452
National Ranking
4370

Overview

Scott A. Armstrong is affiliated with Harvard University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology, hematology, and genetics, with significant engagement in computational theory, mathematics, and oncology.

Their main topics of investigation include acute myeloid leukemia research, protein degradation and inhibitors, epigenetics and DNA methylation, genomics and chromatin dynamics, advanced mathematical modeling in engineering, histone deacetylase inhibitors research, and CRISPR and genetic engineering.

Frequent publication venues for Armstrong's work include Blood with 26 publications, arXiv (Cornell University) featuring 9 publications, bioRxiv (Cold Spring Harbor Laboratory) with 7 publications, as well as Cancer Discovery and Cancer Research, each with 6 publications.

Armstrong has collaborated frequently with several researchers. Notable coauthors include Florian Perner, Charlie Hatton, Daniela V. Wenge, Jevon Cutler, and Chun-Wei Chen.

Recent papers published by Armstrong and collaborators include the following:

  • The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia, 2023, Nature
  • Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia, 2020, Science
  • MEN1 mutations mediate clinical resistance to menin inhibition, 2023, Nature
  • Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition, 2021, Cell Metabolism
  • The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML, 2021, Blood

Best Publications

  • The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

    Justin Lamb;Emily D. Crawford;David Peck;Joshua W. Modell

  • Mll translocations specify a distinct gene expression profile, distinguishing a unique leukemia

    Todd R. Golub;Scott A. Armstrong;Stanley J. Korsmeyer

  • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

    Zuzana Tothova;Zuzana Tothova;Ramya Kollipara;Brian J. Huntly;Benjamin H. Lee;Benjamin H. Lee

  • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

    Andrei V. Krivtsov;David Twomey;David Twomey;Zhaohui Feng;Matthew C. Stubbs

  • Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

    Michael Certo;Victoria Del Gaizo Moore;Mari Nishino;Guo Wei

  • MLL translocations, histone modifications and leukaemia stem-cell development

    Andrei V. Krivtsov;Scott A. Armstrong

  • High-throughput oncogene mutation profiling in human cancer

    Roman K. Thomas;Alissa C. Baker;Ralph M. DeBiasi;Ralph M. DeBiasi;Wendy Winckler;Wendy Winckler

  • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor

    Scott R. Daigle;Edward J. Olhava;Carly A. Therkelsen;Christina R. Majer

  • MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

    Kathrin M. Bernt;Nan Zhu;Amit U. Sinha;Sridhar Vempati

  • The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

    Yingzi Wang;Andrei Krivtsov;Amit U. Sinha;Trista Elizabeth North;Trista Elizabeth North

  • Chromatin-modifying enzymes as modulators of reprogramming

    Tamer T. Onder;Nergis Kara;Anne Cherry;Amit U. Sinha

  • Defective forebrain development in mice lacking gp330/megalin

    Thomas E. Willnow;Jan Hilpert;Scott A. Armstrong;Astrid Rohlmann

  • H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

    Andrei V. Krivtsov;Zhaohui Feng;Madeleine E. Lemieux;Joerg Faber

  • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

    Guo Wei;Guo Wei;David Twomey;David Twomey;Justin Lamb;Krysta Schlis

  • Molecular Genetics of Acute Lymphoblastic Leukemia

    Scott A. Armstrong;A. Thomas Look

  • Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification

    Scott A Armstrong;Andrew L Kung;Andrew L Kung;Meghann E Mabon;Lewis B Silverman;Lewis B Silverman

  • The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

    Ross L. Levine;Marc Loriaux;Brian J. P. Huntly;Mignon L. Loh

  • Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

    Adolfo A. Ferrando;Scott A. Armstrong;Donna S. Neuberg;Stephen E. Sallan

  • Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

    Glenn S Cowley;Barbara A Weir;Barbara A Weir;Francisca Vazquez;Francisca Vazquez;Pablo Tamayo

  • Chromatin-modifying enzymes as modulators of reprogramming

    Tamer T. Onder;Nergis Kara;Anne Cherry;Amit U. Sinha

Frequent Co-Authors

Richard Koche
Richard Koche Memorial Sloan Kettering Cancer Center
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Lars Bullinger
Lars Bullinger Charité - University Medicine Berlin
Guoliang Xu
Guoliang Xu Fudan University
Stephen E. Sallan
Stephen E. Sallan Harvard University
James E. Bradner
James E. Bradner Amgen (United States)
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Ari Melnick
Ari Melnick Cornell University
D. Gary Gilliland
D. Gary Gilliland Fred Hutchinson Cancer Research Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Scott A. Armstrong

Trending Scientists