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Molecular Biology
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Molecular Biology

D-Index
159
Citations
116602
World Ranking
66
National Ranking
45

Medicine

D-Index
160
Citations
117389
World Ranking
770
National Ranking
434

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2010 - Ho-Am Prize in Medicine, Samsung Foundation
  • 1953 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

William C. Hahn is affiliated with Harvard University in the United States. Their research spans several fields within the biomedical sciences, primarily focusing on molecular biology, oncology, and cancer research. The main fields of study include biochemistry, genetics, and molecular biology, along with medicine. Subfields of their work incorporate molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and genetics.

The scientist's research topics cover diverse aspects of cancer biology and treatment. Key topics include cancer genomics and diagnostics, pancreatic and hepatic oncology research, single-cell and spatial transcriptomics, prostate cancer treatment and research, CRISPR and genetic engineering, cancer cells and metastasis, and ubiquitin and proteasome pathways.

Several recent papers demonstrate the scope of their work. Notable publications include:

  • "Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer" (2021, Cell)
  • "Biologically informed deep neural network for prostate cancer discovery" (2021, Nature)
  • "Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects" (2021, Genome Biology)
  • "An expanded universe of cancer targets" (2021, Cell)
  • "Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer" (2021, Nature Communications)

William C. Hahn frequently collaborates with other researchers, including Francisca Vázquez, David E. Root, Andrew J. Aguirre, Jesse S. Boehm, and James M. McFarland, illustrating extensive cooperative research efforts within their scientific community.

Publications are often found in specialized venues focused on cancer and biomedical research. Frequent publication venues for this scientist include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature Communications
  • Nature

Throughout their career, William C. Hahn has received recognition for their contributions to medical science with awards such as the Ho-Am Prize in Medicine from the Samsung Foundation in 2010. Additional honors include being named a Fellow of the American Association for the Advancement of Science (AAAS) and membership in the Association of American Physicians.

Best Publications

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Creation of human tumour cells with defined genetic elements

    William C. Hahn;William C. Hahn;Christopher M. Counter;Ante S. Lundberg;Ante S. Lundberg;Roderick L. Beijersbergen

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Malignant astrocytic glioma: genetics, biology, and paths to treatment.

    Frank B. Furnari;Tim Fenton;Robert M. Bachoo;Akitake Mukasa

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

    Jason Moffat;Dorre A. Grueneberg;Xiaoping Yang;So Young Kim;So Young Kim

  • Lentivirus-delivered stable gene silencing by RNAi in primary cells.

    Sheila A. Stewart;Derek M. Dykxhoorn;Deborah Palliser;Hana Mizuno

  • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

    Andrei V. Krivtsov;David Twomey;David Twomey;Zhaohui Feng;Matthew C. Stubbs

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • Initial genome sequencing and analysis of multiple myeloma

    Michael A. Chapman;Michael S. Lawrence;Jonathan J. Keats;Kristian Cibulskis

  • Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Vasanthi S. Viswanathan;Matthew J. Ryan;Harshil D. Dhruv;Shubhroz Gill

  • Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

    Susan Bullman;Susan Bullman;Chandra S. Pedamallu;Chandra S. Pedamallu;Ewa Sicinska;Thomas E. Clancy

  • Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.

    Mark A. Dickson;William C. Hahn;William C. Hahn;Yasushi Ino;Vincent Ronfard

  • Inhibition of telomerase limits the growth of human cancer cells

    William C. Hahn;Sheila A. Stewart;Mary W. Brooks;Shoshana G. York

  • Modelling the molecular circuitry of cancer.

    William C Hahn;William C Hahn;Robert A Weinberg

  • Rules for making human tumor cells.

    William C. Hahn;Robert A. Weinberg

  • Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

    Sonam Dolma;Stephen L Lessnick;Stephen L Lessnick;William C Hahn;William C Hahn;Brent R Stockwell

  • Recurrent BRAF mutations in Langerhans cell histiocytosis

    Gayane Badalian-Very;Gayane Badalian-Very;Jo-Anne Vergilio;Jo-Anne Vergilio;Barbara A. Degar;Barbara A. Degar;Laura E. MacConaill

Frequent Co-Authors

Francisca Vazquez
Francisca Vazquez Broad Institute
Jesse S. Boehm
Jesse S. Boehm Broad Institute
David E. Root
David E. Root Broad Institute
Matthew Meyerson
Matthew Meyerson Harvard University
Levi A. Garraway
Levi A. Garraway Roche (United States)
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Rameen Beroukhim
Rameen Beroukhim Harvard University
Gad Getz
Gad Getz Broad Institute

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