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Francisca Vazquez

Francisca Vazquez

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
34524
World Ranking
5458
National Ranking
2589

Overview

Francisca Vazquez is affiliated with the Broad Institute in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research covers a broad spectrum of topics, with significant focus on cancer genomics and diagnostics, CRISPR and genetic engineering, protein degradation and inhibitors, RNA modifications and cancer, as well as ubiquitin and proteasome pathways.

  • Cancer Genomics and Diagnostics
  • CRISPR and Genetic Engineering
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer
  • Ubiquitin and proteasome pathways
  • Single-cell and spatial transcriptomics
  • Multiple Myeloma Research and Treatments

The subfields in which Francisca Vazquez has published include molecular biology, cancer research, genetics, oncology, and cell biology. These areas complement their focus on the molecular and cellular mechanisms underlying cancer and related diseases.

  • Molecular Biology
  • Cancer Research
  • Genetics
  • Oncology
  • Cell Biology

Francisca Vazquez's recent publications represent notable contributions to cancer biology and gene editing technologies. These include:

  • Discovering the anticancer potential of non-oncology drugs by systematic viability profiling, 2020, Nature Cancer
  • Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects, 2021, Genome biology
  • Cas9 activates the p53 pathway and selects for p53-inactivating mutations, 2020, Nature Genetics
  • An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence, 2021, Cancer Cell
  • An expanded universe of cancer targets, 2021, Cell

The frequent co-authors collaborating with Francisca Vazquez include professionals active in cancer genetics and molecular biology research, such as:

  • William C. Hahn
  • Joshua M. Dempster
  • Aviad Tsherniak
  • James M. McFarland
  • Jesse S. Boehm

Francisca Vazquez also has a consistent publication record in prominent scientific journals, especially those specializing in cancer and molecular biology research. The venues reflecting their scholarly output are:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Communications
  • Cell Reports

Their work integrates experimental approaches and computational models to investigate cellular responses in cancer, focusing on gene fitness, drug repurposing, and tumor adaptation mechanisms. This multidisciplinary approach spans both fundamental molecular biology and applied oncology research.

Best Publications

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

    Robin M Meyers;Jordan G Bryan;James M McFarland;Barbara A Weir

  • mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

    John T. Cunningham;Joseph T. Rodgers;Daniel H. Arlow;Francisca Vazquez

  • Regulation of G1 Progression by the PTEN Tumor Suppressor Protein Is Linked to Inhibition of the Phosphatidylinositol 3-kinase/Akt Pathway

    Shivapriya Ramaswamy;Noriaki Nakamura;Francisca Vazquez;David B. Batt

  • β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

    Joseph Rosenbluh;Deepak Nijhawan;Deepak Nijhawan;Deepak Nijhawan;Andrew G. Cox;Andrew G. Cox;Xingnan Li

  • Genetic and transcriptional evolution alters cancer cell line drug response

    Uri Ben-David;Benjamin Siranosian;Gavin Ha;Gavin Ha;Helen Tang

  • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

    Hongbing Zhang;Gregor Cicchetti;Hiroaki Onda;Henry B. Koon

  • PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

    Francisca Vazquez;Ji Hong Lim;Helen Chim;Kavita Bhalla

  • Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

    Noriaki Nakamura;Shivapriya Ramaswamy;Francisca Vazquez;Sabina Signoretti;Sabina Signoretti

  • TSC2 regulates VEGF through mTOR-dependent and -independent pathways

    James B Brugarolas;Francisca Vazquez;Archana Reddy;William R Sellers

  • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.

    Steven M. Corsello;Steven M. Corsello;Rohith T. Nagari;Ryan D. Spangler;Jordan Rossen

  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

    Andrew J Aguirre;Robin M Meyers;Barbara A. Weir;Francisca Vázquez

  • METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

    Francisca Vázquez;Gregg Hastings;Maria Asunción Ortega;Timothy F Lane

  • MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.

    Gregory V. Kryukov;Gregory V. Kryukov;Frederick H. Wilson;Frederick H. Wilson;Jason R. Ruth;Jason R. Ruth;Joshiawa Paulk;Joshiawa Paulk

  • Mutational processes shape the landscape of TP53 mutations in human cancer

    Andrew O. Giacomelli;Andrew O. Giacomelli;Xiaoping Yang;Robert E. Lintner;James M. McFarland

  • Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

    Glenn S Cowley;Barbara A Weir;Barbara A Weir;Francisca Vazquez;Francisca Vazquez;Pablo Tamayo

  • The landscape of cancer cell line metabolism

    Haoxin Li;Haoxin Li;Shaoyang Ning;Mahmoud Ghandi;Gregory V. Kryukov

  • High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

    Maria I. Torres-Arzayus;Jaime Font de Mora;Jing Yuan;Francisca Vazquez

  • The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

    Mark M Pomerantz;Fugen Li;David Y Takeda;David Y Takeda;Romina Lenci

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
David E. Root
David E. Root Broad Institute
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Levi A. Garraway
Levi A. Garraway Roche (United States)
Charles W. M. Roberts
Charles W. M. Roberts St. Jude Children's Research Hospital
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University

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