World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
54252
World Ranking
3781
National Ranking
1871

John G. Doench publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where John G. Doench sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 663 publications — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

John G. Doench D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John G. Doench sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 81 D-Index — 81st percentile

81% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

John G. Doench is affiliated with the Broad Institute in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a significant focus on medicine. The scientist's published work highlights expertise in molecular biology, oncology, immunology, infectious diseases, and genetics, reflecting a broad range of biological disciplines.

The primary research topics covered by John G. Doench include:

  • CRISPR and Genetic Engineering
  • Interferon and immune responses
  • RNA and protein synthesis mechanisms
  • CAR-T cell therapy research
  • Advanced biosensing and bioanalysis techniques
  • Protein degradation and inhibitors
  • Epigenetics and DNA methylation

The scientist has contributed extensively to the scientific literature, with frequent publications appearing in well-known venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Blood
  • Cancer Research
  • Nature

Among the recent papers authored or co-authored by John G. Doench are:

  • "Discovering the anticancer potential of non-oncology drugs by systematic viability profiling," 2020, Nature Cancer
  • "Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis," 2020, Nature Chemical Biology
  • "Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection," 2020, Cell
  • "Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway," 2021, Cell
  • "Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity," 2020, Cell Metabolism

Collaboration is a notable aspect of their research career, with frequent co-authors including:

  • David E. Root
  • Mudra Hegde
  • Peter C. DeWeirdt
  • William C. Hahn
  • Ruth E. Hanna

John G. Doench's body of work reflects substantial contributions to the understanding of genetic editing technologies, immune response mechanisms, and cellular pathways relevant to disease. Their research encompasses both foundational molecular biology and applied medical sciences, contributing to ongoing developments in cancer biology, immunology, and infectious disease research.

Best Publications

  • Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Ophir Shalem;Ophir Shalem;Neville E Sanjana;Neville E Sanjana;Ella Hartenian;Xi-Shun Shi

  • Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

    John G Doench;Nicolo Fusi;Meagan Sullender;Mudra Hegde

  • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

    Aravind Subramanian;Rajiv Narayan;Steven M. Corsello;Steven M. Corsello;David D. Peck

  • Specificity of microRNA target selection in translational repression

    John G. Doench;Phillip A. Sharp

  • siRNAs can function as miRNAs

    John G. Doench;Christian P. Petersen;Phillip A. Sharp

  • Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

    John G Doench;Ella Hartenian;Daniel B Graham;Zuzana Tothova

  • Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Vasanthi S. Viswanathan;Matthew J. Ryan;Harshil D. Dhruv;Shubhroz Gill

  • In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

    Robert T. Manguso;Robert T. Manguso;Hans W. Pope;Hans W. Pope;Margaret D. Zimmer;Margaret D. Zimmer;Flavian D. Brown

  • A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

    Deng Pan;Aya Kobayashi;Aya Kobayashi;Peng Jiang;Lucas Ferrari de Andrade

  • Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

    Bjoern Chapuy;Michael R. McKeown;Charles Y. Lin;Stefano Monti

  • Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Kendall R. Sanson;Ruth E. Hanna;Mudra Hegde;Katherine F. Donovan

  • Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

    Jeffrey J. Ishizuka;Jeffrey J. Ishizuka;Robert T. Manguso;Robert T. Manguso;Collins K. Cheruiyot;Collins K. Cheruiyot;Kevin Bi;Kevin Bi

  • A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

    Yilong Zou;Yilong Zou;Michael J. Palte;Amy A. Deik;Haoxin Li;Haoxin Li

  • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.

    Steven M. Corsello;Steven M. Corsello;Rohith T. Nagari;Ryan D. Spangler;Jordan Rossen

  • Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

    Jin Wei;Mia Madel Alfajaro;Peter C. DeWeirdt;Ruth E. Hanna

  • Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.

    Yilong Zou;Haoxin Li;Haoxin Li;Emily T. Graham;Amy A. Deik

  • Mutational processes shape the landscape of TP53 mutations in human cancer

    Andrew O. Giacomelli;Andrew O. Giacomelli;Xiaoping Yang;Robert E. Lintner;James M. McFarland

  • Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

    Jun Wei;Lingyun Long;Wenting Zheng;Yogesh Dhungana

  • Am I ready for CRISPR? A user's guide to genetic screens.

    John G Doench

  • A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

    Jason D. Arroyo;Jason D. Arroyo;Alexis A. Jourdain;Alexis A. Jourdain;Sarah E. Calvo;Sarah E. Calvo;Carmine A. Ballarano;Carmine A. Ballarano

Frequent Co-Authors

David E. Root
David E. Root Broad Institute
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Todd R. Golub
Todd R. Golub Harvard University
Jesse S. Boehm
Jesse S. Boehm Broad Institute
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
W. Nicholas Haining
W. Nicholas Haining Arsenal Biosciences (United States)
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Francisca Vazquez
Francisca Vazquez Broad Institute
Matthew Meyerson
Matthew Meyerson Harvard University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University

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