World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
138
Citations
93302
World Ranking
289
National Ranking
197

Medicine

D-Index
137
Citations
93149
World Ranking
1867
National Ranking
1061

Research.com Recognitions

  • 2017 - Fellow of the American Academy of Arts and Sciences
  • 2016 - Member of the National Academy of Sciences
  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Myles Brown is affiliated with Harvard University in the United States. Their research spans the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Within these domains, their work extensively covers subfields such as Molecular Biology, Pulmonary and Respiratory Medicine, Oncology, Cancer Research, and Immunology.

Their scientific contributions focus on several key topics including Prostate Cancer Treatment and Research, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, Cancer Genomics and Diagnostics, Protein Degradation and Inhibitors, Cancer Immunotherapy and Biomarkers, and Ubiquitin and proteasome pathways.

Notable recent publications include:

  • Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data, 2020, Genome Biology
  • Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade, 2021, Cancer Discovery
  • An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence, 2021, Cancer Cell
  • Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer, 2020, Cancer Research
  • Integrative analyses of single-cell transcriptome and regulome using MAESTRO, 2020, Genome Biology

Myles Brown frequently collaborates with several researchers, including:

  • Henry W. Long
  • Xintao Qiu
  • Paloma Cejas
  • X. Shirley Liu
  • Clifford A. Meyer

Their research has been published extensively in scientific venues such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Cancer Therapeutics
  • UNC Libraries

Awards recognizing their scientific contributions include:

  • Fellow of the American Academy of Arts and Sciences, 2017
  • Member of the National Academy of Sciences, 2016
  • Fellow of the American Association for the Advancement of Science (AAAS), 2014
  • Member of the Association of American Physicians

Best Publications

  • Model-based Analysis of ChIP-Seq (MACS)

    Yong Zhang;Tao Liu;Clifford A Meyer;Jérôme Eeckhoute

  • Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

    Peng Jiang;Shengqing Gu;Deng Pan;Jingxin Fu

  • MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens.

    Wei Li;Han Xu;Tengfei Xiao;Le Cong;Le Cong

  • Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.

    Yongfeng Shang;Xiao Hu;James DiRenzo;Mitchell A Lazar

  • Genome-wide analysis of estrogen receptor binding sites

    Jason S Carroll;Clifford A Meyer;Jun Song;Wei Li

  • Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1

    Jason S. Carroll;X. Shirley Liu;Alexander S. Brodsky;Wei Li

  • Molecular determinants for the tissue specificity of SERMs.

    Yongfeng Shang;Myles Brown

  • FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

    Mathieu Lupien;Jérôme Eeckhoute;Clifford A. Meyer;Qianben Wang

  • The CAG repeat within the androgen receptor gene and its relationship to prostate cancer.

    Edward Giovannucci;Meir J. Stampfer;Krishna Krithivas;Myles Brown

  • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

    Qianben Wang;Wei Li;Yong Zhang;Xin Yuan

  • X chromosomal abnormalities in basal-like human breast cancer

    Andrea L. Richardson;Zhigang C. Wang;Arcangela De Nicolo;Arcangela De Nicolo;Xin Lu

  • XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

    Xi Chen;Dimitrios Iliopoulos;Dimitrios Iliopoulos;Qing Zhang;Qianzi Tang;Qianzi Tang

  • Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

    Sheng Yu Ku;Spencer Rosario;Yanqing Wang;Ping Mu

  • Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

    Ker Yu;William Bayona;Caleb B. Kallen;Heather P. Harding

  • EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

    Kexin Xu;Zhenhua Jeremy Wu;Anna C. Groner;Housheng Hansen He

  • Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

    Butler Mg;Dasouki Mj;Zhou Xp;Talebizadeh Z

  • Formation of the Androgen Receptor Transcription Complex

    Yongfeng Shang;Molly Myers;Myles Brown

  • Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription

    Shlomit Halachmi;Emily Marden;Glover Martin;Heather MacKay

  • A Hierarchical Network of Transcription Factors Governs Androgen Receptor-Dependent Prostate Cancer Growth

    Qianben Wang;Wei Li;X. Shirley Liu;Jason S. Carroll

  • Cistrome: an integrative platform for transcriptional regulation studies.

    Tao Liu;Jorge A Ortiz;Len Taing;Clifford A Meyer

Frequent Co-Authors

X. Shirley Liu
X. Shirley Liu Harvard University
Henry W. Long
Henry W. Long Harvard University
Clifford A. Meyer
Clifford A. Meyer Harvard University
Philip W. Kantoff
Philip W. Kantoff Memorial Sloan Kettering Cancer Center
Jason S. Carroll
Jason S. Carroll University of Cambridge
Housheng Hansen He
Housheng Hansen He University of Toronto
Massimo Loda
Massimo Loda Cornell University
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
Rulla M. Tamimi
Rulla M. Tamimi Cornell University
Qianben Wang
Qianben Wang Duke University

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