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Housheng Hansen He

Housheng Hansen He

D-Index & Metrics

Genetics

D-Index
59
Citations
16056
World Ranking
3220
National Ranking
120

Overview

Housheng Hansen He is affiliated with the University of Toronto in Canada and has a significant body of research primarily focused on molecular biology and cancer research. Their work encompasses key areas within biochemistry, genetics, and molecular biology, with an emphasis on oncology, pulmonary and respiratory medicine, and immunology.

Their research explores various topics including prostate cancer treatment and research, epigenetics and DNA methylation, RNA modifications and cancer, cancer-related molecular mechanisms, cancer-related gene regulation, cancer genomics and diagnostics, and RNA research and splicing.

Some of their recent publications include:

  • Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression (2021, Nature Cell Biology)
  • Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy (2021, Cell)
  • The DNA methylation landscape of advanced prostate cancer (2020, Nature Genetics)
  • RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target (2020, Gastroenterology)
  • EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer (2021, Nature Cancer)

Frequent co-authors who have collaborated extensively with Housheng Hansen He include Sujun Chen, Yong Zeng, Fraser Soares, Musaddeque Ahmed, and Paul C. Boutros.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • Cancer Research
  • Nature Genetics

Major fields of study for Housheng Hansen He include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study reflect an emphasis on:

  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Oncology
  • Immunology

Key research topics addressed across their publications involve:

  • Prostate Cancer Treatment and Research
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • Cancer-related gene regulation
  • Cancer Genomics and Diagnostics
  • RNA Research and Splicing

Best Publications

  • EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

    Kexin Xu;Zhenhua Jeremy Wu;Anna C. Groner;Housheng Hansen He

  • Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

    David A. Quigley;Ha X. Dang;Shuang G. Zhao;Paul Lloyd

  • Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

    Shaokun Shu;Charles Y. Lin;Housheng Hansen He;Robert M. Witwicki

  • Genomic hallmarks of localized, non-indolent prostate cancer

    Michael Fraser;Veronica Y. Sabelnykova;Takafumi N. Yamaguchi;Lawrence E. Heisler

  • LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

    Wanqiang Sheng;Wanqiang Sheng;Martin W. LaFleur;Thao H. Nguyen;Sujun Chen;Sujun Chen

  • Nucleosome dynamics define transcriptional enhancers.

    Housheng Hansen He;Clifford A. Meyer;Hyunjin Shin;Shannon T. Bailey

  • Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1

    Changmeng Cai;Housheng Hansen He;Sen Chen;Ilsa Coleman

  • 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

    Nasim Ahmadiyeh;Mark M. Pomerantz;Chiara Grisanzio;Paula Herman

  • Widespread and Functional RNA Circularization in Localized Prostate Cancer

    Sujun Chen;Sujun Chen;Sujun Chen;Vincent Huang;Xin Xu;Julie Livingstone

  • Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

    Sumaiyah K. Rehman;Jennifer Haynes;Evelyne Collignon;Kevin R. Brown

  • GlcNAcylation of histone H2B facilitates its monoubiquitination

    Ryoji Fujiki;Waka Hashiba;Hiroki Sekine;Atsushi Yokoyama

  • Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

    Teng Fei;Teng Fei;Yiwen Chen;Tengfei Xiao;Wei Li

  • Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

    Sujun Chen;Guanghui Zhu;Yue Yang;Fubo Wang

  • Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

    Yufei Xu;Chao Xu;Akiko Kato;Wolfram Tempel

  • Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19

    Junjie Tony Hua;Junjie Tony Hua;Musaddeque Ahmed;Haiyang Guo;Yuzhe Zhang;Yuzhe Zhang;Yuzhe Zhang

  • The DNA methylation landscape of advanced prostate cancer

    Shuang G. Zhao;Shuang G. Zhao;William S. Chen;William S. Chen;Haolong Li;Adam Foye

  • Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification

    Housheng Hansen He;Clifford A. Meyer;Sheng'En Shawn Hu;Sheng'En Shawn Hu;Mei Wei Chen

  • Differentiation-Specific Histone Modifications Reveal Dynamic Chromatin Interactions and Partners for the Intestinal Transcription Factor CDX2

    Michael P. Verzi;Hyunjin Shin;H. Hansen He;Rita Sulahian;Rita Sulahian

  • Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

    Haiyang Guo;Musaddeque Ahmed;Fan Zhang;Cindy Q Yao

  • Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

    Shaokun Shu;Charles Y. Lin;Housheng Hansen He;Robert M. Witwicki

Frequent Co-Authors

Myles Brown
Myles Brown Harvard University
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
X. Shirley Liu
X. Shirley Liu Harvard University
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles
Steven P. Balk
Steven P. Balk Beth Israel Deaconess Medical Center
Robert G. Bristow
Robert G. Bristow University of Manchester
Theodorus H. van der Kwast
Theodorus H. van der Kwast University Health Network
Amina Zoubeidi
Amina Zoubeidi University of British Columbia
Martin E. Gleave
Martin E. Gleave University of British Columbia
Trevor J. Pugh
Trevor J. Pugh Princess Margaret Cancer Centre

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