What is he best known for?
The fields of study he is best known for:
Ross D. Hannan mostly deals with Molecular biology, Cell biology, RNA polymerase I, Transcription and Ribosome biogenesis.
His Molecular biology study incorporates themes from Chromatin, Serum response factor, Transcription factor, Chromatin remodeling and Response element.
His work on PI3K/AKT/mTOR pathway and Protein kinase B as part of general Cell biology study is frequently connected to Telophase, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His studies in Protein kinase B integrate themes in fields like Senescence and Cancer research.
His RNA polymerase I research incorporates elements of Ribosomal RNA and Ribosome.
His Transcription research is multidisciplinary, incorporating elements of TATA-binding protein and Pol1 Transcription Initiation Complex Proteins.
His most cited work include:
- mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. (345 citations)
- mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. (345 citations)
- Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. (333 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Cell biology, Transcription, Cancer research, RNA polymerase I and Molecular biology.
His is involved in several facets of Cell biology study, as is seen by his studies on PI3K/AKT/mTOR pathway, Signal transduction, Protein kinase B and Phosphorylation.
His Transcription study integrates concerns from other disciplines, such as RNA, Transcription factor, Ribosome biogenesis, Ribosomal DNA and RNA polymerase II.
His Cancer research research focuses on Bioinformatics and how it connects with In vivo and Disease.
His research integrates issues of Chromatin, Ribosomal RNA and Gene expression in his study of RNA polymerase I.
His research in Molecular biology intersects with topics in Response element, Pol1 Transcription Initiation Complex Proteins and RRNA transcription.
He most often published in these fields:
- Cell biology (50.59%)
- Transcription (34.12%)
- Cancer research (30.98%)
What were the highlights of his more recent work (between 2018-2021)?
- Cell biology (50.59%)
- Cancer research (30.98%)
- Transcription (34.12%)
In recent papers he was focusing on the following fields of study:
Ross D. Hannan mainly investigates Cell biology, Cancer research, Transcription, RNA polymerase I and Ribosome biogenesis.
His Cell biology research integrates issues from Cancer cell and Messenger RNA.
His Cancer research research incorporates themes from Cancer, DNA damage, Topotecan, Combination therapy and Neuroblastoma.
His Transcription research includes themes of Adverse effect, DNA, Toxicity, RNA-binding protein and Ribosome.
His work carried out in the field of RNA polymerase I brings together such families of science as Chromatin, Anaplastic large-cell lymphoma and Gene expression.
His Ribosome biogenesis research is multidisciplinary, relying on both mTORC1, Argonaute, Lymphoma, Gene silencing and Mediator.
Between 2018 and 2021, his most popular works were:
- First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study (40 citations)
- The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. (26 citations)
- CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer. (21 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Transcription, Cell biology, Cancer research, RNA polymerase I and Chromatin.
His studies in Transcription integrate themes in fields like Binding protein and DNA.
His research related to Protein kinase B and PI3K/AKT/mTOR pathway might be considered part of Cell biology.
His Cancer research study combines topics from a wide range of disciplines, such as DNA damage, Homologous recombination, Myeloid-Lymphoid Leukemia Protein, Gene silencing and Leukemia.
His Ribosome biogenesis research extends to the thematically linked field of RNA polymerase I.
As a member of one scientific family, Ross D. Hannan mostly works in the field of Chromatin, focusing on Ribosomal RNA and, on occasion, Biogenesis, Histone and Cellular homeostasis.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
