His primary scientific interests are in Cell biology, PI3K/AKT/mTOR pathway, Initiation factor, Translation and Protein biosynthesis. His PI3K/AKT/mTOR pathway research is multidisciplinary, relying on both Protein kinase B and Eukaryotic initiation factor. He frequently studies issues relating to Cell growth and Initiation factor.
His Translation study is related to the wider topic of Genetics. His biological study spans a wide range of topics, including Cell cycle and Internal ribosome entry site, Ribosome. The various areas that he examines in his RPTOR study include mTORC1, Cancer research and Carcinogenesis.
His scientific interests lie mostly in Cell biology, Cancer research, Translation, PI3K/AKT/mTOR pathway and EIF4E. His research in Cell biology intersects with topics in Regulation of gene expression, Cell growth and Initiation factor. His Cancer research research integrates issues from Cancer cell, Cancer, Prostate cancer, Oncogene and Immunology.
His Translation research incorporates elements of RNA, Ribosome, Computational biology and Protein biosynthesis. His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in Protein kinase B and Eukaryotic initiation factor. His EIF4E study integrates concerns from other disciplines, such as Carcinogenesis and Phosphorylation.
His primary areas of investigation include Cell biology, Translation, Cancer research, Cancer and Cancer cell. His research integrates issues of Regulation of gene expression, Small nucleolar RNA and Protein biosynthesis in his study of Cell biology. His research integrates issues of Cell, Gene expression, RNA, Ribosome and Regulator in his study of Translation.
His Cancer research study integrates concerns from other disciplines, such as mTORC1, Protein kinase B, PI3K/AKT/mTOR pathway and Prostate cancer. His Cancer study combines topics in areas such as Computational biology and In vivo, Biodistribution. His work is dedicated to discovering how Cancer cell, EIF4E are connected with Translation factor, Diffuse mesangial sclerosis, Carrier protein and Protein overexpression and other disciplines.
Davide Ruggero focuses on Cancer research, Cell biology, Cancer cell, Human proteins and Severe acute respiratory syndrome coronavirus 2. His work carried out in the field of Cancer research brings together such families of science as Adaptive response, ISRIB, Phosphorylation, Prostate cancer and Eukaryotic initiation factor. His biological study spans a wide range of topics, including Translation and Circadian clock.
Davide Ruggero interconnects Protein Interaction Networks and Molecular targets in the investigation of issues within Human proteins. He combines subjects such as microRNA, Cell growth and Initiation factor with his study of Endoplasmic reticulum. Protein biosynthesis is often connected to PI3K/AKT/mTOR pathway in his work.
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu.
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan;Rebecca D. Riba;Stergios Zacharoulis;Anna H. Bramley.
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Morris E Feldman;Beth Apsel;Aino Uotila;Robbie Loewith.
PLOS Biology (2009)
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Andrew C. Hsieh;Yi Liu;Merritt P. Edlind;Nicholas T. Ingolia.
Does the ribosome translate cancer
Davide Ruggero;Pier Paolo Pandolfi.
Nature Reviews Cancer (2003)
Pml is essential for multiple apoptotic pathways
Zhu-Gang Wang;Davide Ruggero;Simona Ronchetti;Sue Zhong.
Nature Genetics (1998)
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
Davide Ruggero;Davide Ruggero;Lorenzo Montanaro;Li Ma;Wei Xu.
Nature Medicine (2004)
IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
John-Paul Upton;Likun Wang;Dan Han;Eric S. Wang.
Autism-related deficits via dysregulated eIF4E-dependent translational control
Christos G. Gkogkas;Arkady Khoutorsky;Israeli Ran;Emmanouil Rampakakis.
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
Andrew C. Hsieh;Maria Costa;Ornella Zollo;Cole Davis.
Cancer Cell (2010)
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