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Medicine

D-Index
79
Citations
60979
World Ranking
17331
National Ranking
8684

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David Lyden is affiliated with Cornell University in the United States and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work emphasizes molecular biology, oncology, cancer research, immunology, and pulmonary and respiratory medicine.

The scientist's main research topics include extracellular vesicles in disease, microRNA in disease regulation, cancer genomics and diagnostics, spaceflight effects on biology, lung cancer treatments and mutations, immune cells in cancer, and immunotherapy and immune responses.

Several recent papers illustrate the scope of their research contributions. These include:

  • A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids, 2020, Cell Stem Cell
  • Tumour extracellular vesicles and particles induce liver metabolic dysfunction, 2023, Nature
  • Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism, 2021, Nature Cancer
  • Immune determinants of the pre-metastatic niche, 2023, Cancer Cell
  • Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain, 2021, Nature Cancer

Frequent publication venues for their work include Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature, and Nature Cancer. Cancer Research is the venue with the highest number of publications.

The scientist has collaborated extensively, with frequent co-authors being Irina Matei, Haiying Zhang, Linda Bojmar, Serena Lucotti, and Michele Cioffi.

David Lyden's research integrates knowledge across multiple disciplines related to the mechanisms of cancer progression, immune cell behavior in oncological contexts, and the roles of extracellular vesicles and microRNA in disease processes.

Among their recognitions, they are a member of the Association of American Physicians.

Best Publications

  • Tumour exosome integrins determine organotropic metastasis

    Ayuko Hoshino;Bruno Costa-Silva;Tang-Long Shen;Goncalo Rodrigues

  • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Héctor Peinado;Maša Alečković;Simon Lavotshkin;Irina Matei

  • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

    Rosandra N. Kaplan;Rebecca D. Riba;Stergios Zacharoulis;Anna H. Bramley

  • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

    Bruno Costa-Silva;Nicole M. Aiello;Allyson J. Ocean;Swarnima Singh

  • Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

    David Lyden;Koichi Hattori;Koichi Hattori;Sergio Dias;Carla Costa

  • Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

    Beate Heissig;Koichi Hattori;Sergio Dias;Matthias Friedrich

  • Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.

    Shahin Rafii;David Lyden

  • Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

    Monica Garcia-Barros;Francois Paris;Carlos Cordon-Cardo;David Lyden

  • Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

    Annette Becker;Basant Kumar Thakur;Joshua Mitchell Weiss;Han Sang Kim;Han Sang Kim

  • Use of double-stranded dna in exosomes: a novel biomarker in cancer detection

    David C. Lyden;Hector Peinado Selgas;Haiying Zhang;Basant Kumar Thakur

  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

    Haiying Zhang;Daniela Freitas;Han Sang Kim;Han Sang Kim;Kristina Fabijanic

  • Pre-metastatic niches: organ-specific homes for metastases

    Héctor Peinado;Haiying Zhang;Irina R. Matei;Bruno Costa-Silva

  • The metastatic niche: adapting the foreign soil

    Bethan Psaila;David Lyden;David Lyden

  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

    David Lyden;Alison Z. Young;David Zagzag;Wei Yan

  • CD133 expression is not restricted to stem cells, and both CD133 + and CD133 – metastatic colon cancer cells initiate tumors

    Sergey V. Shmelkov;Jason M. Butler;Andrea T. Hooper;Adilia Hormigo

  • The perivascular niche regulates breast tumour dormancy

    Cyrus M. Ghajar;Héctor Peinado;Hidetoshi Mori;Irina R. Matei

  • Exosome-Mediated Metastasis: Communication from a Distance.

    Inbal Wortzel;Shani Dror;Candia M. Kenific;David Lyden

  • Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

    Koichi Hattori;Sergio Dias;Beate Heissig;Neil R. Hackett

  • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

    Scott T. Avecilla;Koichi Hattori;Beate Heissig;Rafael Tejada

  • Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

    Shahin Rafii;David Lyden;David Lyden;Robert Benezra;Robert Benezra;Koichi Hattori

Frequent Co-Authors

Shahin Rafii
Shahin Rafii Cornell University
Héctor Peinado
Héctor Peinado Spanish National Cancer Research Centre
Daniel J. Hicklin
Daniel J. Hicklin Eli Lilly (United States)
Yibin Kang
Yibin Kang Princeton University
Suzanne L. Wolden
Suzanne L. Wolden Memorial Sloan Kettering Cancer Center
Henrik Molina
Henrik Molina Rockefeller University
Ronald G. Crystal
Ronald G. Crystal Cornell University
Neil R. Hackett
Neil R. Hackett Cornell University
Jason T. Huse
Jason T. Huse The University of Texas MD Anderson Cancer Center
Robert Benezra
Robert Benezra Memorial Sloan Kettering Cancer Center

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