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Medicine

D-Index
115
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71592
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4445
National Ranking
2423

Overview

Daniel J. Hicklin is affiliated with Eli Lilly in the United States. Their research primarily focuses on fields within Medicine and Biochemistry, Genetics and Molecular Biology, with a specific emphasis on Oncology, Immunology, Radiology, Nuclear Medicine and Imaging, Biotechnology, and Genetics.

The scientist has contributed extensively to the study of CAR-T cell therapy research and monoclonal and polyclonal antibodies research. Other notable research topics include cancer research and treatments, immunotherapy and immune responses, cancer immunotherapy and biomarkers, immune cell function and interaction, and virus-based gene therapy research.

Daniel J. Hicklin has a record of publications in several scientific venues. Frequent publication venues include:

  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Cancer Immunology Research
  • Cancer Treatment and Research Communications
  • Blood

Their recent papers cover various aspects of immunotherapy and tumor biology. Selected recent publications include:

  • mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity, 2023, Cancer Immunology Research
  • Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody, 2021, Cancer Treatment and Research Communications
  • Conditionally Activated IL-12 or IFNα Indukine™ Molecules Inhibit Syngeneic Lymphoma Tumor Growth in Mice, Induce Anti-Tumor Immune Responses and Are Tolerated in Non-Human Primates, 2021, Blood
  • 715 WTX-330 is an IL-12 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models, 2021, Regular and Young Investigator Award Abstracts
  • 718 WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives antitumor immunity in murine syngeneic cancer models, 2021, Regular and Young Investigator Award Abstracts

The scientist frequently collaborates with several co-authors, including:

  • Andrés Salmerón
  • Christopher J. Nirschl
  • William M. Winston
  • Heather R. Brodkin
  • Jenna M. Sullivan

Best Publications

  • Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

    Daniel J. Hicklin;Lee M. Ellis

  • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

    Rosandra N. Kaplan;Rebecca D. Riba;Stergios Zacharoulis;Anna H. Bramley

  • Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

    Mario Peichev;Afzal J. Naiyer;Daniel Pereira;Zhenping Zhu

  • mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

    Kathryn E. O'Reilly;Fredi Rojo;Qing Bai She;David Solit

  • Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

    David Lyden;Koichi Hattori;Koichi Hattori;Sergio Dias;Carla Costa

  • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

    Peter Carmeliet;Lieve Moons;Aernout Luttun;Valeria Vincenti

  • VEGF-targeted therapy: mechanisms of anti-tumour activity

    Lee M. Ellis;Daniel J. Hicklin

  • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

    Oriol Casanovas;Daniel J. Hicklin;Gabriele Bergers;Douglas Hanahan

  • Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

    Christine H. Chung;Beloo Mirakhur;Emily Chan;Quynh Thu Le

  • Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.

    Francesco M. Marincola;Elizabeth M. Jaffee;Daniel J. Hicklin;Soldano Ferrone

  • Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

    Ricky T. Tong;Yves Boucher;Sergey V. Kozin;Frank Winkler

  • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

    Frank Winkler;Sergey V. Kozin;Ricky T. Tong;Sung-Suk Chae

  • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

    Giannoula Klement;Sylvain Baruchel;Janusz Rak;Shan Man

  • Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1

    Aernout Luttun;Marc Tjwa;Lieve Moons;Yan Wu

  • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

    B. Oosthuyse;L. Moons;E. Storkebaum;H. Beck

  • Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2+AC133+ Endothelial Precursor Cells

    Muhammad Gill;Sergio Dias;Koichi Hattori;Mary Lee Rivera

  • Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

    Monica Autiero;Johannes Waltenberger;Didier Communi;Andrea Kranz

  • Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

    Koichi Hattori;Sergio Dias;Beate Heissig;Neil R. Hackett

  • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

    Scott T. Avecilla;Koichi Hattori;Beate Heissig;Rafael Tejada

  • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment

    Koichi Hattori;Beate Heissig;Yan Wu;Sergio Dias

Frequent Co-Authors

Peter Bohlen
Peter Bohlen Eli Lilly (United States)
Lee M. Ellis
Lee M. Ellis The University of Texas MD Anderson Cancer Center
Robert S. Kerbel
Robert S. Kerbel University of Toronto
Shahin Rafii
Shahin Rafii Cornell University
Soldano Ferrone
Soldano Ferrone Harvard University
David Lyden
David Lyden Cornell University
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Neil R. Hackett
Neil R. Hackett Cornell University
Rakesh K. Jain
Rakesh K. Jain Harvard University
Elisabetta Dejana
Elisabetta Dejana Uppsala University

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