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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
22524
World Ranking
5534
National Ranking
2629

Overview

Neil R. Hackett is affiliated with Cornell University in the United States. Their research spans key areas in biochemistry, genetics, molecular biology, and medicine, with a focus on physiology, molecular biology, genetics, and cellular and molecular neuroscience. Hackett's work also touches on epidemiology.

The primary research topics include lysosomal storage disorders, virus-based gene therapy, RNA regulation and disease, adenosine and purinergic signaling, CRISPR and genetic engineering, nuclear receptors and signaling, and cytomegalovirus and herpesvirus research.

Hackett has published in several scientific venues. Frequent publication outlets include Molecular Therapy and Human Gene Therapy, each hosting three of their works. Other venues include Science Translational Medicine, EMBO Molecular Medicine, and Molecular Therapy - Methods & Clinical Development.

  • Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2, 2020, Science Translational Medicine
  • Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47, 2024, EMBO Molecular Medicine
  • Combination HSCT and intravenous AAV-mediated gene therapy in a canine model proves pivotal for translation of Krabbe disease therapy, 2023, Molecular Therapy
  • AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice, 2024, Molecular Therapy
  • Twenty-Year Survival Analysis of Adeno-Associated Virus Vector Serotype 2-Mediated Gene Therapy to the Central Nervous System for CLN2 Disease, 2025, Human Gene Therapy

Frequent collaborators in Hackett's research include Ronald G. Crystal, Dolan Sondhi, Stephen M. Kaminsky, Jonathan B. Rosenberg, and Philip L. Leopold.

Best Publications

  • Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

    David Lyden;Koichi Hattori;Koichi Hattori;Sergio Dias;Carla Costa

  • Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

    Beate Heissig;Koichi Hattori;Sergio Dias;Matthias Friedrich

  • Angiogenesis Gene Therapy Phase I Assessment of Direct Intramyocardial Administration of an Adenovirus Vector Expressing VEGF121 cDNA to Individuals With Clinically Significant Severe Coronary Artery Disease

    Todd K. Rosengart;Leonard Y. Lee;Shailen R. Patel;Timothy A. Sanborn

  • Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

    Koichi Hattori;Sergio Dias;Beate Heissig;Neil R. Hackett

  • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

    Scott T. Avecilla;Koichi Hattori;Beate Heissig;Rafael Tejada

  • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment

    Koichi Hattori;Beate Heissig;Yan Wu;Sergio Dias

  • Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

    David K Jin;Koji Shido;Hans-Georg Kopp;Isabelle Petit

  • Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.

    Koichi Hattori;Beate Heissig;Kei Tashiro;Tasuku Honjo

  • Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.

    Stefan Worgall;Dolan Sondhi;Neil R. Hackett;Barry Kosofsky

  • Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

    Charles A. Mack;Shailen R. Patel;Eric A. Schwarz;Pat Zanzonico

  • Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells

    Philip L. Leopold;Barbara Ferris;Irene Grinberg;Stefan Worgall

  • Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors

    Pouneh Kermani;Dahlia Rafii;David K. Jin;Paul Whitlock

  • Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA.

    Todd K. Rosengart;Leonard Y. Lee;Shailen R. Patel;Paul D. Kligfield

  • Variability of Antioxidant-Related Gene Expression in the Airway Epithelium of Cigarette Smokers

    Neil R. Hackett;Adriana Heguy;Ben-Gary Harvey;Timothy P. O'Connor

  • Circumvention of Anti-Adenovirus Neutralizing Immunity by Administration of an Adenoviral Vector of an Alternate Serotype

    Charles A. Mack;Wen-Ru Song;Heather Carpenter;Tom J. Wickham

  • Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus

    B G Harvey;P L Leopold;N R Hackett;T M Grasso

  • Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor.

    Hwai-Loong Kong;Dalit Hecht;Wenru Song;Imre Kovesdi

  • CAR-dependent and CAR-independent pathways of adenovirus vector–mediated gene transfer and expression in human fibroblasts

    Chisa Hidaka;Eric Milano;Philip L. Leopold;Jeffrey M. Bergelson

  • Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.

    Naoki Miyazawa;Philip L. Leopold;Neil R. Hackett;Barbara Ferris

  • Variability of Human Systemic Humoral Immune Responses to Adenovirus Gene Transfer Vectors Administered to Different Organs

    Ben-Gary Harvey;Neil R. Hackett;Tarek El-Sawy;Todd K. Rosengart

Frequent Co-Authors

Ronald G. Crystal
Ronald G. Crystal Cornell University
Shahin Rafii
Shahin Rafii Cornell University
Philip L. Leopold
Philip L. Leopold Cornell University
James M. Wilson
James M. Wilson University of Pennsylvania
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Barry E. Kosofsky
Barry E. Kosofsky Cornell University
Fan Zhang
Fan Zhang University of British Columbia
David Lyden
David Lyden Cornell University
Daniel A. Peterson
Daniel A. Peterson Rosalind Franklin University of Medicine and Science

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