World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15021
World Ranking
9157
National Ranking
4062

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Avrum Spira is affiliated with Boston University in the United States. Their research portfolio spans key areas within medicine, with significant contributions to biochemistry, genetics, and molecular biology.

Their work primarily addresses topics such as cancer genomics and diagnostics, cancer-related molecular mechanisms, single-cell and spatial transcriptomics, lung cancer diagnosis and treatment, RNA modifications and cancer, cancer immunotherapy and biomarkers, and cancer cells and metastasis.

Frequent coauthors in their research include Marc E. Lenburg, Jennifer Beane, Sarah A. Mazzilli, Humam Kadara, and Ansam Sinjab.

They have published extensively in several venues, notably in Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), CHEST Journal, Scientific Reports, and Cancer Discovery.

Significant papers include:

  • The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution, 2020, Cell
  • The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma, 2022, Cancer Discovery
  • Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing, 2021, Cancer Discovery
  • Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD, 2020, Scientific Reports
  • An atlas of epithelial cell states and plasticity in lung adenocarcinoma, 2024, Nature

Their research fields include pulmonary and respiratory medicine, molecular biology, cancer research, oncology, and infectious diseases.

Avrum Spira has been recognized as a member of the Association of American Physicians.

Best Publications

  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

    Carly G.K. Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian M. Mbano

  • Effects of cigarette smoke on the human airway epithelial cell transcriptome

    Avrum Spira;Jennifer Beane;Vishal Shah;Gang Liu

  • Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    Avrum Spira;Jennifer E Beane;Vishal Shah;Katrina Steiling

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.

    Frank Schembri;Sriram Sridhar;Catalina Perdomo;Adam M. Gustafson

  • Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges

    Luis M. Seijo;Nir Peled;Daniel Ajona;Mattia Boeri

  • Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.

    Arash Hossein-nezhad;Avrum Spira;Michael F. Holick

  • Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.

    Stephanie A. Christenson;Katrina Steiling;Maarten van den Berge;Kahkeshan Hijazi

  • Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development

    Adam M. Gustafson;Raffaella Soldi;Christina Anderlind;Mary Beth Scholand

  • A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer

    Gerard A. Silvestri;Anil Vachani;Duncan Whitney;Michael Elashoff

  • Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.

    Marc A. Sze;Pedro A. Dimitriu;Masaru Suzuki;Masaru Suzuki;John E. McDonough

  • State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer.

    Jerome S Brody;Avrum Spira

  • Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium

    Sriram Sridhar;Frank Schembri;Julie Zeskind;Vishal Shah

  • Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression

    Jennifer Beane;Jennifer Beane;Paola Sebastiani;Gang Liu;Jerome S Brody

  • The SERPINE2 Gene Is Associated with Chronic Obstructive Pulmonary Disease

    Dawn L. DeMeo;Dawn L. DeMeo;Thomas J. Mariani;Thomas J. Mariani;Christoph Lange;Sorachai Srisuma;Sorachai Srisuma;Sorachai Srisuma

  • Gene Expression Profiling of Human Lung Tissue from Smokers with Severe Emphysema

    Avrum Spira;Jennifer Beane;Victor Pinto-Plata;Aran Kadar

  • Association of Interferon‐ and Transforming Growth Factor β–Regulated Genes and Macrophage Activation With Systemic Sclerosis–Related Progressive Lung Fibrosis

    Romy B. Christmann;Romy B. Christmann;Percival Sampaio-Barros;Giuseppina Stifano;Claudia L. Borges

  • miR-129 regulates cell proliferation by downregulating Cdk6 expression

    Junjie Wu;Jun Qian;Chun Li;Letty Kwok

  • Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

    Vitor H. Teixeira;Christodoulos P. Pipinikas;Adam Pennycuick;Henry Lee-Six

  • Electronic cigarettes: a task force report from the European Respiratory Society

    Robert Bals;Jeanette Boyd;Susanna Esposito;Robert Foronjy

Frequent Co-Authors

Marc E. Lenburg
Marc E. Lenburg Boston University
Steven M. Dubinett
Steven M. Dubinett University of California, Los Angeles
Humam Kadara
Humam Kadara The University of Texas MD Anderson Cancer Center
Wim Timens
Wim Timens University Medical Center Groningen
Dirkje S. Postma
Dirkje S. Postma University Medical Center Groningen
David A. Schwartz
David A. Schwartz University of Colorado Denver
Naftali Kaminski
Naftali Kaminski Yale University
Frank C. Sciurba
Frank C. Sciurba University of Pittsburgh
Gang Liu
Gang Liu University of Alabama at Birmingham
John Quackenbush
John Quackenbush Harvard University

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