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Genetics

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Overview

Heather J. Cordell is a researcher affiliated with Newcastle University in the United Kingdom. Their work spans multiple aspects of medicine, with a particular focus on liver disease, genetics, and molecular biology.

The scientist has contributed extensively to the fields of epidemiology, genetics, molecular biology, hepatology, and cardiology and cardiovascular medicine. Their research incorporates a broad range of topics including liver disease diagnosis and treatment, liver diseases and immunity, genetic associations and epidemiology, diet and metabolism-related diseases, alcohol consumption and health effects, congenital heart disease studies, and pediatric hepatobiliary diseases and treatments.

Recent notable papers authored or co-authored by Cordell include:

  • Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort, 2020, Journal of Hepatology
  • Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis, 2020, Science Translational Medicine
  • Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis, 2021, Journal of Hepatology
  • A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation, 2022, Nature Genetics
  • An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs, 2021, Journal of Hepatology

Cordell frequently collaborates with several researchers in their field, including:

  • Rebecca Darlay
  • Ann K. Daly
  • Quentin M. Anstee
  • Christopher P. Day
  • Bernard Keavney

The primary venues for publication include:

  • Journal of Hepatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genetic Epidemiology
  • Journal of Hypertension
  • PLoS Genetics

Heather J. Cordell's research output predominantly focuses on medicine and biochemistry, genetics, and molecular biology, with 152 and 63 publications respectively in these main fields. The subfields reflect an interdisciplinary approach involving epidemiology, genetics, molecular biology, hepatology, and cardiovascular medicine.

Best Publications

  • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

    H Ueda;Howson Jmm.;L Esposito;J Heward

  • A genome-wide search for human type 1 diabetes susceptibility genes

    J L Davies;Y Kawaguchi;Y Kawaguchi;Bennett;Bennett;J B Copeman;J B Copeman

  • Detecting gene-gene interactions that underlie human diseases

    Heather J Cordell

  • Haplotype tagging for the identification of common disease genes

    Gillian C.L. Johnson;Laura Esposito;Bryan J. Barratt;Annabel N. Smith

  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

    Evangelos Evangelou;Evangelos Evangelou;Helen R. Warren;Helen R. Warren;David Mosen-Ansorena;Borbala Mifsud

  • Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans

    Heather J. Cordell

  • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.

    Ann K Daly;Peter T Donaldson;Pallav Bhatnagar;Yufeng Shen

  • Genetic association studies

    Heather J Cordell;David G Clayton

  • Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

    Sara J. Brown;Sara J. Brown;Sara J. Brown;Yuka Asai;Heather J. Cordell;Linda E. Campbell

  • Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

    Elke Rodriguez;Hansjoerg Baurecht;Esther Herberich;Stefan Wagenpfeil

  • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

    George F Mells;James A B Floyd;Katherine I Morley;Katherine I Morley;Heather J Cordell

  • A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes.

    Heather J. Cordell;David G. Clayton

  • Research capacity. Enabling the genomic revolution in Africa

    Charles Rotimi;Akin Abayomi;Alash'le Abimiku;Victoria May Adabayeri

  • Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping.

    P W Reed;J L Davies;J L Davies;J B Copeman;J B Copeman;Bennett;Bennett

  • Polygenic control of autoimmune diabetes in nonobese diabetic mice

    Ghosh S;Palmer Sm;Rodrigues Nr;Cordell Hj

  • The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis

    Marco Carbone;Stephen J. Sharp;Steve Flack;Dimitrios Paximadas

  • Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort.

    Quentin M. Anstee;Quentin M. Anstee;Rebecca Darlay;Simon Cockell;Marica Meroni

  • Contribution of Global Rare Copy-Number Variants to the Risk of Sporadic Congenital Heart Disease

    Rachel Soemedi;Ian J. Wilson;Jamie Bentham;Rebecca Darlay

  • Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects.

    Heather J. Cordell;Bryan J. Barratt;David G. Clayton

  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

    Evangelos Evangelou;Helen R. Warren;David Mosen-Ansorena;Borbala Mifsu

Frequent Co-Authors

Bernard Keavney
Bernard Keavney University of Manchester
John A. Todd
John A. Todd University of Oxford
Martin Farrall
Martin Farrall University of Oxford
Judith A. Goodship
Judith A. Goodship Newcastle University
Jenefer M. Blackwell
Jenefer M. Blackwell Telethon Kids Institute
Markus Perola
Markus Perola Finnish Institute for Health and Welfare
Hugh Watkins
Hugh Watkins University of Oxford
Andrew P. Morris
Andrew P. Morris University of Liverpool
Graeme J. M. Alexander
Graeme J. M. Alexander University College London
Francesco Cucca
Francesco Cucca University of Sassari

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