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Biology and Biochemistry

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89
Citations
42218
World Ranking
2502
National Ranking
12

Medicine

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90
Citations
43151
World Ranking
11993
National Ranking
31

Research.com Recognitions

  • 2021 - Fellow of the Royal Society of Edinburgh
  • 2020 - Member of Academia Europaea
  • 2019 - Member of the Royal Irish Academy

Overview

Alan D. Irvine is affiliated with Trinity College Dublin in Ireland and has an extensive publication record in the field of medicine, with a particular focus on dermatology and immunology. Their work spans several subfields, including dermatology, immunology and allergy, physiology, immunology, and rheumatology.

The main research topics covered by Irvine include dermatology and skin diseases, allergic rhinitis and sensitization, asthma and respiratory diseases, food allergy and anaphylaxis research, urticaria and related conditions, adrenal hormones and disorders, and transgenic plants and applications.

Recent published papers authored by or associated with Irvine include:

  • Atopic dermatitis, 2020, The Lancet
  • The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation, 2020, Cell Metabolism
  • Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials, 2021, The Lancet
  • Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis, 2023, New England Journal of Medicine
  • The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata, 2020, Journal of the American Academy of Dermatology

Irvine frequently collaborates with several co-authors, including:

  • Carsten Flohr
  • Amy S. Paller
  • Jonathan I. Silverberg
  • Stephan Weidinger
  • Eric L. Simpson

Their work is regularly published in notable venues such as:

  • British Journal of Dermatology
  • Journal of the American Academy of Dermatology
  • Journal of Investigative Dermatology
  • Allergy
  • Journal of the European Academy of Dermatology and Venereology

Irvine has been recognized with several memberships and honors, including becoming a Fellow of the Royal Society of Edinburgh in 2021, a Member of Academia Europaea in 2020, and a Member of the Royal Irish Academy in 2019.

Best Publications

  • Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

    Colin N A Palmer;Alan D Irvine;Ana Terron-Kwiatkowski;Yiwei Zhao

  • Filaggrin Mutations Associated with Skin and Allergic Diseases

    Alan D Irvine;W H Irwin McLean;Donald Y M Leung;Donald Y M Leung

  • Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

    Frances J D Smith;Alan D Irvine;Ana Terron-Kwiatkowski;Aileen Sandilands

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1

    Amy Strange;Francesca Capon;Chris C A Spencer

  • Filaggrin in the frontline: role in skin barrier function and disease.

    Aileen Sandilands;Calum Sutherland;Alan D. Irvine;Alan D. Irvine;W. H. Irwin McLean

  • Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.

    S Chavanas;C Bodemer;A Rochat;D Hamel-Teillac

  • Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.

    Aileen Sandilands;Ana Terron-Kwiatkowski;Peter R Hull;Gráinne M O'Regan

  • Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

    Stephan Weidinger;Thomas Illig;Hansjörg Baurecht;Alan D. Irvine

  • Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

    Lavinia Paternoster;Marie Standl;Johannes Waage;Hansjoerg Baurecht

  • Filaggrin in atopic dermatitis

    Grainne M. O'Regan;Aileen Sandilands;W.H. Irwin McLean;Alan D. Irvine;Alan D. Irvine

  • Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

    Sara J. Brown;Sara J. Brown;Sara J. Brown;Yuka Asai;Heather J. Cordell;Linda E. Campbell

  • A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

    Padraic G Fallon;Takashi Sasaki;Aileen Sandilands;Linda E Campbell

  • Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

    Elke Rodriguez;Hansjoerg Baurecht;Esther Herberich;Stefan Wagenpfeil

  • Filaggrin mutations, atopic eczema, hay fever, and asthma in children

    Stephan Weidinger;Maureen O'Sullivan;Thomas Illig;Hansjoerg Baurecht

  • The multifunctional role of filaggrin in allergic skin disease

    Maeve A. McAleer;Alan D. Irvine;Alan D. Irvine

  • Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation.

    A D Irvine;W H I Mclean

  • Hay–Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

    John A. McGrath;Pascal H.G. Duijf;Volker Doetsch;Alan D. Irvine

  • A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

    A. Strange;F. Capon;C. C. A. Spencer;J. Knight

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    L. C. Tsoi;S. L. Spain;J. Knight;E. Ellinghaus

Frequent Co-Authors

W.H. Irwin McLean
W.H. Irwin McLean University of Dundee
Jonathan O'b. Hourihane
Jonathan O'b. Hourihane Royal College of Surgeons in Ireland
Louise C. Kenny
Louise C. Kenny University of Liverpool
Stephan Weidinger
Stephan Weidinger Kiel University
Carsten Flohr
Carsten Flohr King's College London
Padraic G. Fallon
Padraic G. Fallon Trinity College Dublin
Amy S. Paller
Amy S. Paller Northwestern University
Colin N. A. Palmer
Colin N. A. Palmer University of Dundee
Frances J.D. Smith
Frances J.D. Smith University of Dundee
Richard C. Trembath
Richard C. Trembath King's College London

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