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Genetics
UK
2024
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
137
Citations
63014
World Ranking
207
National Ranking
40

Medicine

D-Index
138
Citations
66979
World Ranking
1837
National Ranking
189

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2016 - Member of Academia Europaea
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Richard C. Trembath is affiliated with King's College London in the United Kingdom. Their research is situated primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to Genetics, Pulmonary and Respiratory Medicine, and Molecular Biology.

Their recent scientific papers cover a range of topics related to genetics, pulmonary hypertension, and epidemiology. Notable publications include:

  • Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations (2020, Cell)
  • MC3R links nutritional state to childhood growth and the timing of puberty (2021, Nature)
  • Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension (2021, European Respiratory Journal)
  • Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH (2021, Genome Medicine)
  • Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals (2022, Nature Communications)

The scientist's work spans several main topics, including:

  • Pulmonary Hypertension Research and Treatments
  • Genetic Associations and Epidemiology
  • Cancer-related molecular mechanisms research
  • Liver Disease Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Diabetes and associated disorders

Frequent co-authors collaborating with Richard C. Trembath include:

  • David A. van Heel
  • Sarah Finer
  • Hilary C. Martin
  • Stefan Gräf
  • Karen A. Hunt

Publications are commonly found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Respiratory Journal
  • Genetics in Medicine
  • Annals of Neurology
  • Nature

Richard C. Trembath's research primarily addresses complex medical and genetic conditions, particularly focusing on pulmonary arterial hypertension, genetics, and molecular biology. Their interdisciplinary approach involves genetic epidemiology and molecular mechanisms underlying disease processes.

Among the honors received is recognition as a Member of Academia Europaea in 2016 and a Fellowship of The Academy of Medical Sciences in the United Kingdom, reflecting their engagement in the medical science community.

Best Publications

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  • Genome-wide association analysis identifies 13 new risk loci for schizophrenia

    Stephan Ripke;Stephan Ripke;Colm T. O'Dushlaine;Kimberly D. Chambert;Jennifer L. Moran

  • Heterozygous germline mutations in BMPR2 , encoding a TGF-β receptor, cause familial primary pulmonary hypertension

    Kirk B. Lane;Rajiv D. Machado;Michael W. Pauciulo;Jennifer R. Thomson

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1

    Amy Strange;Francesca Capon;Chris C A Spencer

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D M Evans;Spencer Cca.;J J Pointon;Z Su

  • Genetics and genomics of pulmonary arterial hypertension

    Florent Soubrier;Wendy K. Chung;Rajiv Machado;Ekkehard Grünig

  • Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia

    Richard Trembath;J R Thomson;Rajiv Machado;N Morgan

  • Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.

    Jennifer R Thomson;Rajiv D Machado;Michael W Pauciulo;Neil V Morgan

  • LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

    Sue Shackleton;David J. Lloyd;Stephen N.J. Jackson;Richard Evans

  • Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

    David Ellinghaus;Luke Jostins;Sarah L. Spain;Adrian Cortes

  • Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

    Elaine Soon;Alan M. Holmes;Carmen M. Treacy;Natalie J. Doughty

  • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Douglas M. Ruderfer;Stephan Ripke;Stephan Ripke;Stephan Ripke;Andrew McQuillin;James Boocock

  • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor.

    Carl Atkinson;Susan Stewart;Paul D. Upton;Rajiv D. Machado

  • Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis

    Richard C. Trembath;R. Lee Clough;Jane L. Rosbotham;Jane L. Rosbotham;Andrew B. Jones

  • PTEN Mutation Spectrum and Genotype-Phenotype Correlations in Bannayan-Riley-Ruvalcaba Syndrome Suggest a Single Entity With Cowden Syndrome

    Debbie J. Marsh;Debbie J. Marsh;Jennifer B. Kum;Jennifer B. Kum;Kathryn L. Lunetta;Michael J. Bennett

  • Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.

    Nicholas W. Morrell;Xudong Yang;Paul D. Upton;Karen B. Jourdan

  • BMPR2 Haploinsufficiency as the Inherited Molecular Mechanism for Primary Pulmonary Hypertension

    Rajiv D Machado;Michael W. Pauciulo;Jennifer R. Thomson;Kirk B. Lane

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D.M. Evans;C.C.A. Spencer;J.J. Pointon;Z. Su

  • A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

    A. Strange;F. Capon;C. C. A. Spencer;J. Knight

Frequent Co-Authors

Jonathan Barker
Jonathan Barker King's College London
Francesca Capon
Francesca Capon King's College London
Nicholas W. Morrell
Nicholas W. Morrell University of Cambridge
Michael A. Simpson
Michael A. Simpson King's College London
Eamonn R. Maher
Eamonn R. Maher University of Cambridge
Matthew A. Brown
Matthew A. Brown Guy's and St Thomas' NHS Foundation Trust
Peter Donnelly
Peter Donnelly University of Oxford
Janusz Jankowski
Janusz Jankowski University College of Osteopathy
Juan P. Casas
Juan P. Casas Boston University
Jenefer M. Blackwell
Jenefer M. Blackwell Telethon Kids Institute

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