World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
160
Citations
95882
World Ranking
790
National Ranking
446

Research.com Recognitions

  • 2010 - Member of the National Academy of Medicine (NAM)
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Charis Eng was affiliated with the Cleveland Clinic Lerner College of Medicine in the United States. Their research focused largely on biochemistry, genetics, and molecular biology, with significant contributions to medicine. The subfields they contributed to included molecular biology, genetics, oncology, cancer research, and pathology and forensic medicine.

The scientist's research topics encompassed a variety of areas related to cancer and genetics, including:

  • PI3K/AKT/mTOR signaling in cancer
  • BRCA gene mutations in cancer
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Genetics and Neurodevelopmental Disorders
  • Bioinformatics and Genomic Networks
  • Protein Kinase Regulation and GTPase Signaling

Several recent papers were part of their publication record, highlighting contributions across multiple domains and years:

  • New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis, 2020, BMC Medicine
  • Target identification among known drugs by deep learning from heterogeneous networks, 2020, Chemical Science
  • Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer, 2021, Genome Medicine
  • Comprehensive characterization of protein-protein interactions perturbed by disease mutations, 2021, Nature Genetics
  • Functional and Taxonomic Dysbiosis of the Gut, Urine, and Semen Microbiomes in Male Infertility, 2021, European Urology

Frequent co-authors who collaborated with them included:

  • Lamis Yehia (42 publications)
  • Thomas Frazier (23 publications)
  • Feixiong Cheng (22 publications)
  • Olufunmilayo I. Olopade (20 publications)
  • Robyn M. Busch (20 publications)

Their work was published in a range of scientific venues, with notable publication counts in:

  • Human Molecular Genetics (12 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (12 publications)
  • UNC Libraries (8 publications)
  • Gastroenterology (7 publications)
  • Cancer Research (7 publications)

During their career, Charis Eng received recognition including:

  • Member of the National Academy of Medicine (NAM), 2010
  • Fellow of the American Association for the Advancement of Science (AAAS), 2003
  • Member of the Association of American Physicians

Best Publications

  • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

    D. Liaw;D. J. Marsh;J. Li;P. L M Dahia

  • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

    L M Mulligan;J B Kwok;C S Healey;M J Elsdon

  • Germ-line mutations in nonsyndromic pheochromocytoma.

    Hartmut P.H. Neumann;Birke Bausch;Sarah R. McWhinney;Bernhard U. Bender

  • Medullary thyroid cancer: management guidelines of the American Thyroid Association.

    Richard T. Kloos;Charis Eng;Douglas B. Evans;Gary L. Francis

  • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis.

    Charis Eng;Charis Eng;David Clayton;Isabelle Schuffenecker;Gilbert Lenoir

  • Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

    Dewi Astuti;Farida Latif;Ashraf Dallol;Patricia L.M. Dahia

  • Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers

    George L. Mutter;Ming Chieh Lin;Jeffrey T. Fitzgerald;Jennifer B. Kum

  • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

    Zhou Songyang;Zhou Songyang;Kermit L. Carraway;Michael J. Eck;Stephen C. Harrison

  • Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity

    Wen Hong Shen;Adayabalam S. Balajee;Jianli Wang;Hong Wu

  • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

    Michael P. Myers;Javor P. Stolarov;Charis Eng;Jing Li

  • PTEN: One Gene, Many Syndromes

    Charis Eng

  • Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.

    Hartmut P. H. Neumann;Christian Pawlu;Mariola Pęczkowska;Birke Bausch

  • Lifetime Cancer Risks in Individuals with Germline PTEN Mutations

    Min Han Tan;Jessica L. Mester;Joanne Ngeow;Lisa A. Rybicki

  • Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

    Butler Mg;Dasouki Mj;Zhou Xp;Talebizadeh Z

  • Localization of the gene for Cowden disease to chromosome 10q22-23

    M. R. Nelen;G. W. Padberg;E. A J Peeters;A. Y. Lin

  • Mutation Spectrum and Genotype-Phenotype Analyses in Cowden Disease and Bannayan-Zonana Syndrome, Two Hamartoma Syndromes With Germline PTEN Mutation

    Debbie J. Marsh;Valérie Coulon;Kathryn L. Lunetta;Philippe Rocca-Serra

  • Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.

    Lois M. Mulligan;Lois M. Mulligan;Charis Eng;Catherine S. Healey;David Clayton

  • Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a BRCA1 or BRCA2 Mutation

    Amy Finch;Mario Beiner;Jan Lubinski;Henry T. Lynch

  • Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

    Debbie J. Marsh;Patricia L. M. Dahia;Zimu Zheng;Danny Liaw

  • Mortality From Second Tumors Among Long-Term Survivors of Retinoblastoma

    Charis Eng;Frederick P. Li;David H. Abramson;Robert M. Ellsworth

Frequent Co-Authors

Hartmut P. H. Neumann
Hartmut P. H. Neumann University of Freiburg
Lois M. Mulligan
Lois M. Mulligan Queen's University
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
Eamonn R. Maher
Eamonn R. Maher University of Cambridge
Patricia L. M. Dahia
Patricia L. M. Dahia The University of Texas Health Science Center at San Antonio
Bruce A.J. Ponder
Bruce A.J. Ponder University of Cambridge
Steven A. Narod
Steven A. Narod University of Toronto
William D. Foulkes
William D. Foulkes McGill University
Henry T. Lynch
Henry T. Lynch Creighton University
Jan Lubinski
Jan Lubinski Pomeranian Medical University

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