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Medicine

D-Index
153
Citations
101185
World Ranking
1030
National Ranking
587

Research.com Recognitions

  • 2008 - Member of the National Academy of Medicine (NAM)

Overview

W. Marston Linehan is affiliated with the National Institutes of Health in the United States, contributing extensively to research in medicine, particularly in the fields of pulmonary and respiratory medicine, oncology, molecular biology, cancer research, and genetics.

Their work covers major topics including lung cancer treatments and mutations, lung cancer research studies, cancer genomics and diagnostics, colorectal cancer treatments and studies, cancer therapeutics and mechanisms, lung cancer diagnosis and treatment, and cancer immunotherapy and biomarkers. These areas reflect a broad and multidisciplinary approach to cancer and molecular biology research.

Among their recent published papers are:

  • A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer (2020, Cell)
  • Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation (2021, Cancer Discovery)
  • Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management (2022, Nature Reviews Clinical Oncology)
  • Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status (2021, Journal of Thoracic Oncology)
  • RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies (2020, Journal of Thoracic Oncology)

Linehan frequently publishes in the following scientific venues:

  • Journal of Clinical Oncology
  • Journal of Thoracic Oncology
  • Annals of Oncology
  • Cancer Research
  • JTO Clinical and Research Reports

They collaborate extensively with several coauthors, including Alexander Drilon, Justin F. Gainor, Andrew Do, Aaron N. Hata, and Ibiayi Dagogo-Jack, reflecting a strong network within oncology and molecular biology research communities.

W. Marston Linehan has been recognized by election to the National Academy of Medicine (NAM) in 2008, indicating contribution to the field at a national level.

Best Publications

  • Comprehensivemolecular characterization of clear cell renal cell carcinoma

    Chad J. Creighton;Margaret Morgan;Preethi H. Gunaratne;Preethi H. Gunaratne;David A. Wheeler

  • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.

    Steven A. Rosenberg;Michael T. Lotze;Linda M. Muul;Alfred E. Chang

  • The Molecular Taxonomy of Primary Prostate Cancer

    Adam Abeshouse;Jaeil Ahn;Rehan Akbani;Adrian Ally

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

    J G Herman;F Latif;Y Weng;M I Lerman

  • von Hippel-Lindau disease

    Russell R Lonser;Gladys M Glenn;McClellan Walther;Emily Y Chew

  • Comparison of MR/Ultrasound Fusion–Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer

    M. Minhaj Siddiqui;M. Minhaj Siddiqui;Soroush Rais-Bahrami;Soroush Rais-Bahrami;Baris Turkbey;Arvin K. George

  • Biochemical diagnosis of pheochromocytoma: which test is best?

    Jacques W. M. Lenders;Karel Pacak;McClellan M. Walther;W. Marston Linehan

  • Reductive carboxylation supports growth in tumour cells with defective mitochondria

    Andrew R. Mullen;William W. Wheaton;Eunsook S. Jin;Pei Hsuan Chen

  • Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.

    Childs R;Chernoff A;Contentin N;Bahceci E

  • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

    W. Marston Linehan;Paul T. Spellman;Christopher J. Ricketts;Chad J. Creighton

  • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

    Jennifer S. Isaacs;Yun Jin Jung;David R. Mole;Sunmin Lee

  • Net Exchange of CO2 in a Mid-Latitude Forest

    S. C. Wofsy;M. L. Goulden;J. W. Munger;S.-M. Fan

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.

    Michael L. Nickerson;Michelle B. Warren;Jorge R. Toro;Vera Matrosova

  • Serum Proteomic Patterns for Detection of Prostate Cancer

    Emanuel F. Petricoin;David K. Ornstein;Cloud P. Paweletz;Ali Ardekani

  • The genetic basis of kidney cancer: a metabolic disease

    W. Marston Linehan;Ramaprasad Srinivasan;Laura S. Schmidt

  • The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

    Caleb F. Davis;Christopher J. Ricketts;Min Wang;Lixing Yang

  • Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma.

    Karel Pacak;W. Marston Linehan;Graeme Eisenhofer;McClellan M. Walther

  • The Molecular Taxonomy of Primary Prostate Cancer

    Adam Abeshouse;Jaeil Ahn;Rehan Akbani;Adrian Ally

Frequent Co-Authors

Laura S. Schmidt
Laura S. Schmidt National Institutes of Health
Maria J. Merino
Maria J. Merino National Institutes of Health
Peter L. Choyke
Peter L. Choyke National Institutes of Health
McClellan M. Walther
McClellan M. Walther National Institutes of Health
Christopher J. Ricketts
Christopher J. Ricketts National Institutes of Health
Berton Zbar
Berton Zbar National Institutes of Health
Peter A. Pinto
Peter A. Pinto National Institutes of Health
Karel Pacak
Karel Pacak National Institutes of Health
Michael R. Emmert-Buck
Michael R. Emmert-Buck Avoneaux Medical Institute
Donald P. Bottaro
Donald P. Bottaro National Institutes of Health

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