William G. Kaelin

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2020 - Fellow of the American Academy of Arts and Sciences

Overview

Best Publications

• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  Mircea Ivan;Keiichi Kondo;Haifeng Yang;William Y. Kim

  5768
  Citations

• Comprehensivemolecular characterization of clear cell renal cell carcinoma

  Chad J. Creighton;Margaret Morgan;Preethi H. Gunaratne;Preethi H. Gunaratne;David A. Wheeler

  4161
  Citations

• Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

  William G. Kaelin;Peter J. Ratcliffe

  4054
  Citations

• Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

  Michael Ohh;Cheol Won Park;Cheol Won Park;Mircea Ivan;Michael A. Hoffman

  1930
  Citations

• The Concept of Synthetic Lethality in the Context of Anticancer Therapy

  William G. Kaelin

  1924
  Citations

• Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

  James Brugarolas;Kui Lei;Rebecca L. Hurley;Brendan D. Manning

  1670
  Citations

• The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

  Gang Lu;Richard E. Middleton;Huahang Sun;MarkVic Naniong

  1472
  Citations

• p73 is a human p53-related protein that can induce apoptosis

  Christine A. Jost;Maria C. Marin;William G. Kaelin

  1301
  Citations

• Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

  Diana Miao;Diana Miao;Claire A. Margolis;Claire A. Margolis;Wenhua Gao;Martin H. Voss;Martin H. Voss

  1263
  Citations

• Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

  Charles E. Stebbins;William G. Kaelin;Nikola P. Pavletich

  1217
  Citations

• Role of VHL Gene Mutation in Human Cancer

  William Y. Kim;William G. Kaelin

  1193
  Citations

• The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

  JianGen Gong;Antonio Costanzo;Hong-Qiong Yang;Gerry Melino

  1186
  Citations

• Molecular basis of the VHL hereditary cancer syndrome

  William G. Kaelin

  1149
  Citations

• Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

  Xiao Qiang Qin;David M. Livingston;William G. Kaelin;Peter D. Adams

  1118
  Citations

• Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

  William G. Kaelin;Wilhelm Krek;William R. Sellers;James A. DeCaprio

  1059
  Citations

• Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

  Othon Iliopoulos;Andrew P. Levy;Chian Jiang;William G. Kaelin

  1054
  Citations

• Influence of Metabolism on Epigenetics and Disease

  William G. Kaelin;Steven L. McKnight

  1022
  Citations

• E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

  Seth J Field;Seth J Field;Fong-Ying Tsai;Fong-Ying Tsai;Frank Kuo;Ana M Zubiaga;Ana M Zubiaga

  1005
  Citations

• Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

  T. Kamura;D. M. Koepp;D. M. Koepp;M. N. Conrad;D. Skowyra

  976
  Citations

• Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

  Jung-Hyun Min;Haifeng Yang;Mircea Ivan;Frank Gertler

  956
  Citations