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William G. Kaelin

William G. Kaelin

Harvard University
United States

Award Badge
Biology and Biochemistry
USA
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
149
Citations
92186
World Ranking
187
National Ranking
129

Medicine

D-Index
149
Citations
92564
World Ranking
1192
National Ranking
688

William G. Kaelin publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where William G. Kaelin sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 346 publications — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

William G. Kaelin D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where William G. Kaelin sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 149 D-Index — 99th percentile

99% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Fellow of the American Academy of Arts and Sciences

Overview

William G. Kaelin is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Within these areas, their subfields of focus include Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Genetics, and Immunology.

The main topics covered in their work include:

  • Cancer, Hypoxia, and Metabolism
  • Renal cell carcinoma treatment
  • Glioma Diagnosis and Treatment
  • Renal and related cancers
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Biochemical and Molecular Research

William G. Kaelin's recent publications demonstrate engagement with cancer biology and molecular mechanisms associated with oxygen sensing and metabolic pathways. Selected recent papers include:

  • "Targeting the HIF2-VEGF axis in renal cell carcinoma," 2020, Nature Medicine
  • "2-Oxoglutarate-dependent dioxygenases in cancer," 2020, Nature Reviews. Cancer
  • "Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions," 2022, Neuro-Oncology
  • "Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer," 2022, Journal of Clinical Investigation
  • "De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma," 2022, Cancer Cell

Frequent co-authors collaborated with include Sabina Signoretti, Samuel K. McBrayer, Diana D. Shi, Toni K. Choueiri, and Nitin H. Shirole.

The venues where William G. Kaelin frequently publishes encompass UNC Libraries, Neuro-Oncology, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, and Nature Medicine.

Among the recognitions awarded, William G. Kaelin was named Fellow of the American Academy of Arts and Sciences in 2020.

Best Publications

  • HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

    Mircea Ivan;Keiichi Kondo;Haifeng Yang;William Y. Kim

  • Comprehensivemolecular characterization of clear cell renal cell carcinoma

    Chad J. Creighton;Margaret Morgan;Preethi H. Gunaratne;Preethi H. Gunaratne;David A. Wheeler

  • Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

    William G. Kaelin;Peter J. Ratcliffe

  • Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

    Michael Ohh;Cheol Won Park;Cheol Won Park;Mircea Ivan;Michael A. Hoffman

  • The Concept of Synthetic Lethality in the Context of Anticancer Therapy

    William G. Kaelin

  • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

    James Brugarolas;Kui Lei;Rebecca L. Hurley;Brendan D. Manning

  • The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

    Gang Lu;Richard E. Middleton;Huahang Sun;MarkVic Naniong

  • p73 is a human p53-related protein that can induce apoptosis

    Christine A. Jost;Maria C. Marin;William G. Kaelin

  • Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

    Diana Miao;Diana Miao;Claire A. Margolis;Claire A. Margolis;Wenhua Gao;Martin H. Voss;Martin H. Voss

  • Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

    Charles E. Stebbins;William G. Kaelin;Nikola P. Pavletich

  • Role of VHL Gene Mutation in Human Cancer

    William Y. Kim;William G. Kaelin

  • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

    JianGen Gong;Antonio Costanzo;Hong-Qiong Yang;Gerry Melino

  • Molecular basis of the VHL hereditary cancer syndrome

    William G. Kaelin

  • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

    Xiao Qiang Qin;David M. Livingston;William G. Kaelin;Peter D. Adams

  • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

    William G. Kaelin;Wilhelm Krek;William R. Sellers;James A. DeCaprio

  • Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

    Othon Iliopoulos;Andrew P. Levy;Chian Jiang;William G. Kaelin

  • Influence of Metabolism on Epigenetics and Disease

    William G. Kaelin;Steven L. McKnight

  • E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

    Seth J Field;Seth J Field;Fong-Ying Tsai;Fong-Ying Tsai;Frank Kuo;Ana M Zubiaga;Ana M Zubiaga

  • Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

    T. Kamura;D. M. Koepp;D. M. Koepp;M. N. Conrad;D. Skowyra

  • Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

    Jung-Hyun Min;Haifeng Yang;Mircea Ivan;Frank Gertler

Frequent Co-Authors

Sabina Signoretti
Sabina Signoretti Brigham and Women's Hospital
David M. Livingston
David M. Livingston Harvard University
William R. Sellers
William R. Sellers Harvard University
Javid Moslehi
Javid Moslehi University of California, San Francisco
Qin Yan
Qin Yan Yale University
Michael Ohh
Michael Ohh University of Toronto
Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Rameen Beroukhim
Rameen Beroukhim Harvard University
Matthew Meyerson
Matthew Meyerson Harvard University
Qing Zhang
Qing Zhang Nanyang Technological University

External Links

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Best Scientists Citing William G. Kaelin

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Publications: 106

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Patrick H. Maxwell

University of Cambridge

Publications: 95

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Publications: 90

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Publications: 89

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Publications: 88

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Publications: 82

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