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2026

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Best Scientists

D-Index
201
Citations
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World Ranking
277
National Ranking
184

Medicine

D-Index
204
Citations
202728
World Ranking
153
National Ranking
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Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Distinguished Scientist Award, American Heart Association
  • 2019 - Nobel Prize for their discoveries of how cells sense and adapt to oxygen availability
  • 2016 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2012 - Member of the National Academy of Medicine (NAM)
  • 2010 - Canada Gairdner International Award
  • 2008 - Member of the National Academy of Sciences
  • 2000 - E. Mead Johnson Award, Society for Pediatric Research
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Gregg L. Semenza is affiliated with Johns Hopkins University School of Medicine in the United States. The primary focus of their research lies within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions to subfields such as Cancer Research, Molecular Biology, Oncology, Genetics, and Physiology.

Their research topics cover a range of important areas, including:

  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • High Altitude and Hypoxia
  • Cancer Research and Treatments
  • Epigenetics and DNA Methylation
  • Adipose Tissue and Metabolism
  • Angiogenesis and VEGF in Cancer

Semenza has published extensively in a variety of scientific journals. Frequent publication venues include:

  • Journal of Clinical Investigation
  • Cell Reports
  • Cancer Research
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Some of their recent notable papers are:

  • "Hypoxia-inducible factors: cancer progression and clinical translation," 2022, Journal of Clinical Investigation
  • "Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness," 2020, Journal of Clinical Investigation
  • "The Genomics and Genetics of Oxygen Homeostasis," 2020, Annual Review of Genomics and Human Genetics
  • "HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia," 2022, Nature Communications
  • "HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation," 2021, Proceedings of the National Academy of Sciences

Frequent collaborators in their research include:

  • Shaima Salman
  • Yongkang Yang
  • Yajing Lyu
  • Haiquan Lu
  • Chelsey Chen

Throughout their career, Semenza has received several awards recognizing their scientific contributions:

  • Distinguished Scientist Award, American Heart Association (2020)
  • Nobel Prize (2019) for discoveries related to how cells sense and adapt to oxygen availability
  • Albert Lasker Award for Basic Medical Research, Lasker Foundation (2016)
  • Member of the National Academy of Medicine (NAM) (2012)
  • Canada Gairdner International Award (2010)
  • Member of the National Academy of Sciences (2008)
  • E. Mead Johnson Award, Society for Pediatric Research (2000)
  • Member of the Association of American Physicians

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting HIF-1 for cancer therapy

    Gregg L. Semenza

  • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

    Guang L. Wang;Bing Hua Jiang;Elizabeth A. Rue;Gregg L. Semenza

  • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.

    Jo A. Forsythe;Bing Hua Jiang;Narayan V. Iyer;Faton Agani

  • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

    Jung Whan Kim;Irina Tchernyshyov;Gregg L. Semenza;Chi V. Dang

  • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

    Gregg L. Semenza;Guang L. Wang

  • Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases

    Hua Zhong;Angelo M. De Marzo;Erik Laughner;Michael Lim

  • Hypoxia-Inducible Factors in Physiology and Medicine

    Gregg L. Semenza

  • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

    Narayan V. Iyer;Lori E. Kotch;Faton Agani;Sandra W. Leung

  • Purification and Characterization of Hypoxia-inducible Factor 1

    Guang L. Wang;Gregg L. Semenza

  • HIF-1: mediator of physiological and pathophysiological responses to hypoxia

    Gregg L. Semenza

  • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

    Gregg L. Semenza;Peter H. Roth;Hon Ming Fang;Guang L. Wang

  • Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics

    Hua Zhong;Kelly Chiles;David Feldser;Erik Laughner

  • Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

    Gregg L. Semenza;Bing-Hua Jiang;Sandra W. Leung;Rosa Passantino

  • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

    Gregg L. Semenza

  • Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

    Huafeng Zhang;Marta Bosch-Marce;Larissa A. Shimoda;Yee Sun Tan

  • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

    Guang L. Wang;Gregg L. Semenza

  • FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

    Patrick C. Mahon;Kiichi Hirota;Gregg L. Semenza

  • HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

    Erik Laughner;Panthea Taghavi;Kelly Chiles;Patrick C. Mahon

  • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

    Rajani Ravi;Bijoyesh Mookerjee;Zaver M. Bhujwalla;Carrie Hayes Sutter

Frequent Co-Authors

Nanduri R. Prabhakar
Nanduri R. Prabhakar University of Chicago
Daniele M. Gilkes
Daniele M. Gilkes Johns Hopkins University
Huafeng Zhang
Huafeng Zhang University of Science and Technology of China
Larissa A. Shimoda
Larissa A. Shimoda Johns Hopkins University
Kiichi Hirota
Kiichi Hirota Kansai Medical University
Chi V. Dang
Chi V. Dang University of Pennsylvania
Bing-Hua Jiang
Bing-Hua Jiang Zhengzhou University
Denis Wirtz
Denis Wirtz Johns Hopkins University
Andre Levchenko
Andre Levchenko Yale University
Gerard A. Lutty
Gerard A. Lutty Johns Hopkins University School of Medicine

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