2022 - Research.com Best Scientist Award
2020 - Distinguished Scientist Award, American Heart Association
2019 - Nobel Prize for their discoveries of how cells sense and adapt to oxygen availability
2016 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
2012 - Member of the National Academy of Medicine (NAM)
2010 - Canada Gairdner International Award
2008 - Member of the National Academy of Sciences
2000 - E. Mead Johnson Award, Society for Pediatric Research
Member of the Association of American Physicians
His scientific interests lie mostly in Cell biology, Transcription factor, Molecular biology, Hypoxia and Vascular endothelial growth factor. His Cell biology study combines topics from a wide range of disciplines, such as Protein subunit, Biochemistry and Oxygen homeostasis. His research in Transcription factor is mostly focused on Hypoxia-Inducible Factor 1.
His Hypoxia study integrates concerns from other disciplines, such as Erythropoietin, Pharmacology and Ischemia. The study incorporates disciplines such as Tumor progression and Angiogenesis, HIF1A in addition to Vascular endothelial growth factor. His biological study spans a wide range of topics, including Cancer, Hypoxia-inducible factors and Pathology.
His primary scientific interests are in Cancer research, Hypoxia, Cell biology, Internal medicine and Endocrinology. His Cancer research research includes themes of Cancer cell, Cancer, Metastasis and Hypoxia-inducible factors. The Hypoxia study combines topics in areas such as Cell, Pulmonary hypertension, Immunology, Ischemia and Pharmacology.
His Cell biology research is multidisciplinary, incorporating perspectives in Hypoxia-Inducible Factor 1, Transcription factor, Oxygen homeostasis and Biochemistry. His Hypoxia-Inducible Factor 1 study incorporates themes from Signal transduction and Transcription. Regulation of gene expression and Enhancer is closely connected to Molecular biology in his research, which is encompassed under the umbrella topic of Transcription factor.
Gregg L. Semenza spends much of his time researching Cancer research, Hypoxia-inducible factors, Internal medicine, Cell biology and Metastasis. His research in Cancer research intersects with topics in Cancer, Cancer cell, Cancer stem cell, Stem cell and Breast cancer. The concepts of his Hypoxia-inducible factors study are interwoven with issues in Oxidative stress, Cell, Angiogenesis, Pathology and Transcription.
His Internal medicine research includes elements of Endocrinology, Retinal and Oncology. His Cell biology research incorporates elements of Regulation of gene expression, Biochemistry, Metabolism and Oxygen homeostasis. Many of his studies on Hypoxia involve topics that are commonly interrelated, such as Signal transduction.
His main research concerns Cancer research, Hypoxia-inducible factors, Metastasis, Cell biology and Cancer cell. Gregg L. Semenza is interested in Angiogenesis, which is a field of Cancer research. His Hypoxia-inducible factors research is multidisciplinary, relying on both Cancer and Pathogenesis.
His Metastasis research is multidisciplinary, incorporating elements of Pathology, Extracellular matrix, Stem cell and Doxorubicin. Gregg L. Semenza combines subjects such as Hypoxia, CDC2 Protein Kinase and Minichromosome maintenance with his study of Cell biology. His work deals with themes such as Hypoxia-Inducible Factor 1 and Oncology, which intersect with Internal medicine.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Targeting HIF-1 for cancer therapy
Gregg L. Semenza.
Nature Reviews Cancer (2003)
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
Guang L. Wang;Bing Hua Jiang;Elizabeth A. Rue;Gregg L. Semenza.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Jo A. Forsythe;Bing Hua Jiang;Narayan V. Iyer;Faton Agani.
Molecular and Cellular Biology (1996)
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Gregg L. Semenza;Guang L. Wang.
Molecular and Cellular Biology (1992)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Jung Whan Kim;Irina Tchernyshyov;Gregg L. Semenza;Chi V. Dang.
Cell Metabolism (2006)
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
Hua Zhong;Angelo M. De Marzo;Erik Laughner;Michael Lim.
Cancer Research (1999)
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer;Lori E. Kotch;Faton Agani;Sandra W. Leung.
Genes & Development (1998)
Hypoxia-Inducible Factors in Physiology and Medicine
Gregg L. Semenza.
Purification and Characterization of Hypoxia-inducible Factor 1
Guang L. Wang;Gregg L. Semenza.
Journal of Biological Chemistry (1995)
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