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Gregg L. Semenza
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Best Scientists
2025
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Medicine
USA
2026

D-Index & Metrics

Best Scientists

D-Index
201
Citations
194892
World Ranking
277
National Ranking
184

Medicine

D-Index
204
Citations
202728
World Ranking
153
National Ranking
104

Gregg L. Semenza publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where Gregg L. Semenza sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 610 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 603 publications — 72nd percentile

72% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

Gregg L. Semenza D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where Gregg L. Semenza sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 399 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 204 D-Index — 99th percentile

99% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Distinguished Scientist Award, American Heart Association
  • 2019 - Nobel Prize for their discoveries of how cells sense and adapt to oxygen availability
  • 2016 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2012 - Member of the National Academy of Medicine (NAM)
  • 2010 - Canada Gairdner International Award
  • 2008 - Member of the National Academy of Sciences
  • 2000 - E. Mead Johnson Award, Society for Pediatric Research
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Gregg L. Semenza is affiliated with Johns Hopkins University School of Medicine in the United States. The primary focus of their research lies within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions to subfields such as Cancer Research, Molecular Biology, Oncology, Genetics, and Physiology.

Their research topics cover a range of important areas, including:

  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • High Altitude and Hypoxia
  • Cancer Research and Treatments
  • Epigenetics and DNA Methylation
  • Adipose Tissue and Metabolism
  • Angiogenesis and VEGF in Cancer

Semenza has published extensively in a variety of scientific journals. Frequent publication venues include:

  • Journal of Clinical Investigation
  • Cell Reports
  • Cancer Research
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Some of their recent notable papers are:

  • "Hypoxia-inducible factors: cancer progression and clinical translation," 2022, Journal of Clinical Investigation
  • "Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness," 2020, Journal of Clinical Investigation
  • "The Genomics and Genetics of Oxygen Homeostasis," 2020, Annual Review of Genomics and Human Genetics
  • "HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia," 2022, Nature Communications
  • "HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation," 2021, Proceedings of the National Academy of Sciences

Frequent collaborators in their research include:

  • Shaima Salman
  • Yongkang Yang
  • Yajing Lyu
  • Haiquan Lu
  • Chelsey Chen

Throughout their career, Semenza has received several awards recognizing their scientific contributions:

  • Distinguished Scientist Award, American Heart Association (2020)
  • Nobel Prize (2019) for discoveries related to how cells sense and adapt to oxygen availability
  • Albert Lasker Award for Basic Medical Research, Lasker Foundation (2016)
  • Member of the National Academy of Medicine (NAM) (2012)
  • Canada Gairdner International Award (2010)
  • Member of the National Academy of Sciences (2008)
  • E. Mead Johnson Award, Society for Pediatric Research (2000)
  • Member of the Association of American Physicians

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting HIF-1 for cancer therapy

    Gregg L. Semenza

  • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

    Guang L. Wang;Bing Hua Jiang;Elizabeth A. Rue;Gregg L. Semenza

  • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.

    Jo A. Forsythe;Bing Hua Jiang;Narayan V. Iyer;Faton Agani

  • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

    Jung Whan Kim;Irina Tchernyshyov;Gregg L. Semenza;Chi V. Dang

  • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

    Gregg L. Semenza;Guang L. Wang

  • Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases

    Hua Zhong;Angelo M. De Marzo;Erik Laughner;Michael Lim

  • Hypoxia-Inducible Factors in Physiology and Medicine

    Gregg L. Semenza

  • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

    Narayan V. Iyer;Lori E. Kotch;Faton Agani;Sandra W. Leung

  • Purification and Characterization of Hypoxia-inducible Factor 1

    Guang L. Wang;Gregg L. Semenza

  • HIF-1: mediator of physiological and pathophysiological responses to hypoxia

    Gregg L. Semenza

  • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

    Gregg L. Semenza;Peter H. Roth;Hon Ming Fang;Guang L. Wang

  • Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics

    Hua Zhong;Kelly Chiles;David Feldser;Erik Laughner

  • Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

    Gregg L. Semenza;Bing-Hua Jiang;Sandra W. Leung;Rosa Passantino

  • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

    Gregg L. Semenza

  • Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

    Huafeng Zhang;Marta Bosch-Marce;Larissa A. Shimoda;Yee Sun Tan

  • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

    Guang L. Wang;Gregg L. Semenza

  • FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

    Patrick C. Mahon;Kiichi Hirota;Gregg L. Semenza

  • HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

    Erik Laughner;Panthea Taghavi;Kelly Chiles;Patrick C. Mahon

  • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

    Rajani Ravi;Bijoyesh Mookerjee;Zaver M. Bhujwalla;Carrie Hayes Sutter

Frequent Co-Authors

Nanduri R. Prabhakar
Nanduri R. Prabhakar University of Chicago
Daniele M. Gilkes
Daniele M. Gilkes Johns Hopkins University
Huafeng Zhang
Huafeng Zhang University of Science and Technology of China
Larissa A. Shimoda
Larissa A. Shimoda Johns Hopkins University
Kiichi Hirota
Kiichi Hirota Kansai Medical University
Chi V. Dang
Chi V. Dang University of Pennsylvania
Bing-Hua Jiang
Bing-Hua Jiang Zhengzhou University
Denis Wirtz
Denis Wirtz Johns Hopkins University
Andre Levchenko
Andre Levchenko Yale University
Gerard A. Lutty
Gerard A. Lutty Johns Hopkins University School of Medicine

External Links

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