H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 144 Citations 135,024 324 World Ranking 95 National Ranking 74
Medicine H-index 146 Citations 94,732 318 World Ranking 490 National Ranking 300

Research.com Recognitions

Awards & Achievements

2020 - Distinguished Scientist Award, American Heart Association

2019 - Nobel Prize for their discoveries of how cells sense and adapt to oxygen availability

2016 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

2012 - Member of the National Academy of Medicine (NAM)

2010 - Canada Gairdner International Award

2008 - Member of the National Academy of Sciences

2000 - E. Mead Johnson Award, Society for Pediatric Research

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Internal medicine

His scientific interests lie mostly in Cell biology, Transcription factor, Molecular biology, Hypoxia and Vascular endothelial growth factor. His Cell biology study combines topics from a wide range of disciplines, such as Protein subunit, Biochemistry and Oxygen homeostasis. His research in Transcription factor is mostly focused on Hypoxia-Inducible Factor 1.

His Hypoxia study integrates concerns from other disciplines, such as Erythropoietin, Pharmacology and Ischemia. The study incorporates disciplines such as Tumor progression and Angiogenesis, HIF1A in addition to Vascular endothelial growth factor. His biological study spans a wide range of topics, including Cancer, Hypoxia-inducible factors and Pathology.

His most cited work include:

  • Targeting HIF-1 for cancer therapy (4879 citations)
  • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension (4775 citations)
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Cancer research, Hypoxia, Cell biology, Internal medicine and Endocrinology. His Cancer research research includes themes of Cancer cell, Cancer, Metastasis and Hypoxia-inducible factors. The Hypoxia study combines topics in areas such as Cell, Pulmonary hypertension, Immunology, Ischemia and Pharmacology.

His Cell biology research is multidisciplinary, incorporating perspectives in Hypoxia-Inducible Factor 1, Transcription factor, Oxygen homeostasis and Biochemistry. His Hypoxia-Inducible Factor 1 study incorporates themes from Signal transduction and Transcription. Regulation of gene expression and Enhancer is closely connected to Molecular biology in his research, which is encompassed under the umbrella topic of Transcription factor.

He most often published in these fields:

  • Cancer research (27.68%)
  • Hypoxia (25.61%)
  • Cell biology (25.80%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cancer research (27.68%)
  • Hypoxia-inducible factors (16.20%)
  • Internal medicine (22.98%)

In recent papers he was focusing on the following fields of study:

Gregg L. Semenza spends much of his time researching Cancer research, Hypoxia-inducible factors, Internal medicine, Cell biology and Metastasis. His research in Cancer research intersects with topics in Cancer, Cancer cell, Cancer stem cell, Stem cell and Breast cancer. The concepts of his Hypoxia-inducible factors study are interwoven with issues in Oxidative stress, Cell, Angiogenesis, Pathology and Transcription.

His Internal medicine research includes elements of Endocrinology, Retinal and Oncology. His Cell biology research incorporates elements of Regulation of gene expression, Biochemistry, Metabolism and Oxygen homeostasis. Many of his studies on Hypoxia involve topics that are commonly interrelated, such as Signal transduction.

Between 2013 and 2021, his most popular works were:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
  • Hypoxia and the extracellular matrix: drivers of tumour metastasis (604 citations)
  • Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA (422 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Internal medicine

His main research concerns Cancer research, Hypoxia-inducible factors, Metastasis, Cell biology and Cancer cell. Gregg L. Semenza is interested in Angiogenesis, which is a field of Cancer research. His Hypoxia-inducible factors research is multidisciplinary, relying on both Cancer and Pathogenesis.

His Metastasis research is multidisciplinary, incorporating elements of Pathology, Extracellular matrix, Stem cell and Doxorubicin. Gregg L. Semenza combines subjects such as Hypoxia, CDC2 Protein Kinase and Minichromosome maintenance with his study of Cell biology. His work deals with themes such as Hypoxia-Inducible Factor 1 and Oncology, which intersect with Internal medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Targeting HIF-1 for cancer therapy

Gregg L. Semenza.
Nature Reviews Cancer (2003)

6976 Citations

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Autophagy (2016)

6803 Citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Guang L. Wang;Bing Hua Jiang;Elizabeth A. Rue;Gregg L. Semenza.
Proceedings of the National Academy of Sciences of the United States of America (1995)

6754 Citations

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Autophagy (2016)

4781 Citations

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.

Jo A. Forsythe;Bing Hua Jiang;Narayan V. Iyer;Faton Agani.
Molecular and Cellular Biology (1996)

4413 Citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza;Guang L. Wang.
Molecular and Cellular Biology (1992)

3453 Citations

Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases

Hua Zhong;Angelo M. De Marzo;Erik Laughner;Michael Lim.
Cancer Research (1999)

3389 Citations

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung Whan Kim;Irina Tchernyshyov;Gregg L. Semenza;Chi V. Dang.
Cell Metabolism (2006)

3185 Citations

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer;Lori E. Kotch;Faton Agani;Sandra W. Leung.
Genes & Development (1998)

2773 Citations

Purification and Characterization of Hypoxia-inducible Factor 1

Guang L. Wang;Gregg L. Semenza.
Journal of Biological Chemistry (1995)

2417 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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