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Mark W. Dewhirst

Mark W. Dewhirst

D-Index & Metrics

Medicine

D-Index
144
Citations
82911
World Ranking
1437
National Ranking
839

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark W. Dewhirst is affiliated with Duke University in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with a substantial body of work spanning 54 publications in medicine and 28 in biochemistry, genetics, and molecular biology.

The scientist's work extends into several specialized subfields, including radiology, nuclear medicine and imaging (15 publications), biomedical engineering (14 publications), pulmonary and respiratory medicine (13 publications), molecular biology (11 publications), and cancer research (10 publications).

The main research topics addressed by Dewhirst include cancer, hypoxia, and metabolism (16 publications), advanced radiotherapy techniques (14 publications), nanoplatforms for cancer theranostics (12 publications), radiation therapy and dosimetry (10 publications), medical imaging techniques and applications (10 publications), ultrasound and hyperthermia applications (8 publications), and autophagy in disease and therapy (8 publications).

Frequent publication venues for their research include UNC Libraries (11 publications), International Journal of Hyperthermia (8 publications), Cancer Research (4 publications), Cancers (3 publications), and Advanced Drug Delivery Reviews (2 publications).

Selected recent papers authored or co-authored by Dewhirst are:

  • Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer, 2020, Cancers
  • Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery, 2021, Advanced Drug Delivery Reviews
  • Psoralen Derivatives with Enhanced Potency, 2020, Photochemistry and Photobiology
  • Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators, 2020, Clinical Cancer Research
  • Transitioning from Gamma Rays to X Rays for Comparable Biomedical Research Irradiations: Energy Matters, 2020, Radiation Research

The scientist collaborates frequently with other researchers, with notable co-authors including Gregory M. Palmer (10 joint publications), Nirmala Ramanujam (7 joint publications), Ashlyn G. Rickard (7 joint publications), Douglas H. Weitzel (3 joint publications), and Jen-Tsan Chi (3 joint publications).

Among the recognitions received, Dewhirst was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

    Shideng Bao;Qiulian Wu;Roger E McLendon;Yueling Hao

  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

    Pierre Sonveaux;Frédérique Végran;Thies Schroeder;Melanie C. Wergin

  • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

    David M. Brizel;Sean P. Scully;John M. Harrelson;Lester J. Layfield

  • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

    David M. Brizel;Gregory S. Sibley;Leonard R. Prosnitz;Richard L. Scher

  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

    Mark W. Dewhirst;Yiting Cao;Benjamin Moeller

  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

    Benjamin J Moeller;Yiting Cao;Chuan Y Li;Mark W Dewhirst

  • Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers

    Matthew R. Dreher;Wenge Liu;Charles R. Michelich;Mark W. Dewhirst

  • Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia

    M. W. Dewhirst;B. L. Viglianti;M. Lora-Michiels;M. Hanson

  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

    David Needham;Gopal Anyarambhatla;Garheng Kong;Mark W. Dewhirst

  • The multifaceted roles of nitric oxide in cancer.

    D A Wink;Y Vodovotz;J Laval;F Laval

  • Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

    Garheng Kong;Rod D. Braun;Mark W. Dewhirst

  • Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome

    David M Brizel;Richard K Dodge;Robert W Clough;Mark W Dewhirst

  • Randomized Trial of Hyperthermia and Radiation for Superficial Tumors

    Ellen L. Jones;James R. Oleson;Leonard R. Prosnitz;Thaddeus V. Samulski

  • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.

    David Needham;Mark W Dewhirst

  • Thresholds for thermal damage to normal tissues: An update

    Pavel S. Yarmolenko;Eui Jung Moon;Chelsea Landon;Ashley Manzoor

  • Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.

    David M Brizel;Thies Schroeder;Richard L Scher;Stefan Walenta

  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

    G Kong;G Anyarambhatla;W P Petros;R D Braun

  • Transport of drugs from blood vessels to tumour tissue.

    Mark W. Dewhirst;Timothy W. Secomb

  • Characterization of the Effect of Hyperthermia on Nanoparticle Extravasation from Tumor Vasculature

    Garheng Kong;Rod D. Braun;Mark W. Dewhirst

  • Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

    Adrianne L. Wong;Zishan A. Haroon;Sabine Werner;Mark W. Dewhirst

Frequent Co-Authors

Timothy W. Secomb
Timothy W. Secomb University of Arizona
Chuan-Yuan Li
Chuan-Yuan Li Duke University
Ivan Spasojevic
Ivan Spasojevic Duke University
Ines Batinic-Haberle
Ines Batinic-Haberle Duke University
Pierre Sonveaux
Pierre Sonveaux Université Catholique de Louvain
Richard K. Dodge
Richard K. Dodge Duke University
Mitchell S. Anscher
Mitchell S. Anscher The University of Texas MD Anderson Cancer Center
Lawrence B. Marks
Lawrence B. Marks University of North Carolina at Chapel Hill
James R. MacFall
James R. MacFall Duke University
Michael R. Zalutsky
Michael R. Zalutsky Duke University

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