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Biology and Biochemistry

D-Index
80
Citations
36897
World Ranking
3993
National Ranking
130

Medicine

D-Index
81
Citations
37936
World Ranking
16394
National Ranking
688

Overview

Bradly G. Wouters is affiliated with the Princess Margaret Cancer Centre in Canada and has a research focus primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these overarching disciplines, their work heavily involves Molecular Biology, Cancer Research, Infectious Diseases, Oncology, and Cardiology and Cardiovascular Medicine as key subfields.

The main topics covered by Bradly G. Wouters' research include Cancer, Hypoxia, and Metabolism; SARS-CoV-2 and COVID-19 Research; RNA modifications and cancer; Cancer Research and Treatments; COVID-19 Clinical Research Studies; Cardiovascular Function and Risk Factors; and Glioma Diagnosis and Treatment.

Frequent coauthors with whom they have collaborated include Mark Zaidi, Marianne Koritzinsky, Jens-Uwe Voigt, Sheila Mansouri, and Gelareh Zadeh.

The scientist's recent papers demonstrate a strong emphasis on cancer biology, tumor metabolism, and translational research in oncology, as well as interdisciplinary studies involving immunotherapy and advanced pathology techniques. Notable publications are:

  • "GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer," 2020, Nature Communications
  • "Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer," 2020, Journal of Clinical Oncology
  • "Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma," 2020, Cell
  • "ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth," 2020, UNC Libraries
  • "In situ tissue pathology from spatially encoded mass spectrometry classifiers visualized in real time through augmented reality," 2020, Chemical Science

Bradly G. Wouters' work has been published frequently in a number of venues, with multiple publications in:

  • Cancer Research
  • European Heart Journal
  • European Heart Journal - Cardiovascular Imaging
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

    Franck Pagès;Bernhard Mlecnik;Florence Marliot;Gabriela Bindea;Gabriela Bindea;Gabriela Bindea

  • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

    Jérôme Galon;Jérôme Galon;Jérôme Galon;Bernhard Mlecnik;Bernhard Mlecnik;Bernhard Mlecnik;Gabriela Bindea;Gabriela Bindea;Gabriela Bindea;Helen K. Angell;Helen K. Angell;Helen K. Angell

  • Hypoxia signalling through mTOR and the unfolded protein response in cancer

    Bradly G. Wouters;Marianne Koritzinsky;Marianne Koritzinsky;Marianne Koritzinsky

  • Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

    J M Brown;B G Wouters

  • Cancer classification using the Immunoscore: a worldwide task force

    Jérôme Galon;Franck Pagès;Francesco M Marincola;Francesco M Marincola;Helen K Angell;Helen K Angell

  • ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

    Meixia Bi;Christine Naczki;Marianne Koritzinsky;Diane Fels

  • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

    Kasper M.A. Rouschop;Twan van den Beucken;Ludwig Dubois;Hanneke Niessen

  • REGULATION OF PROTEIN SYNTHESIS BY HYPOXIA VIA ACTIVATION OF THE ENDOPLASMIC RETICULUM KINASE PERK AND PHOSPHORYLATION OF THE TRANSLATION INITIATION FACTOR EIF2ALPHA

    Constantinos Koumenis;Christine Naczki;Marianne Koritzinsky;Sally Rastani

  • Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

    Tiffany N. Seagroves;Heather E. Ryan;Han Lu;Bradly G. Wouters

  • Activating transcription factor 4 is translationally regulated by hypoxic stress.

    Jaime D. Blais;Vasilisa Filipenko;Meixia Bi;Heather P. Harding

  • Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.

    Judith C. Sluimer;Jean-Marie Gasc;Job L. van Wanroij;Natasja Kisters

  • Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.

    Janine T Erler;Christopher Cawthorne;Kaye J Williams;Marianne Koritzinsky

  • Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy.

    Bradly G. Wouters;J. Martin Brown

  • Time Between the First Day of Chemotherapy and the Last Day of Chest Radiation Is the Most Important Predictor of Survival in Limited-Disease Small-Cell Lung Cancer

    Dirk De Ruysscher;Madelon Pijls-Johannesma;Søren M. Bentzen;André Minken

  • Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

    Marianne Koritzinsky;Michaël G Magagnin;Twan van den Beucken;Renaud Seigneuric

  • The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

    Peter van Galen;Antonija Kreso;Nathan Mbong;David G. Kent

  • Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

    Norman Chan;Marianne Koritzinsky;Helen Zhao;Helen Zhao;Ranjit Bindra

  • Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

    Vanessa E. Zannella;Alan Dal Pra;Alan Dal Pra;Hala Muaddi;Hala Muaddi;Trevor D. McKee

  • Validation of bioelectrical-impedance measurements as a method to estimate body-water compartments.

    W. D. Van Marken Lichtenbelt;K. R. Westerterp;L. Wouters;S. C. M. Luijendijk

Frequent Co-Authors

Philippe Lambin
Philippe Lambin Maastricht University
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles
David W. Hedley
David W. Hedley Princess Margaret Cancer Centre
Robert G. Bristow
Robert G. Bristow University of Manchester
Ming-Sound Tsao
Ming-Sound Tsao Princess Margaret Cancer Centre
Richard P. Hill
Richard P. Hill Princess Margaret Cancer Centre
adrian l harris
adrian l harris University of Oxford
Michael Milosevic
Michael Milosevic Princess Margaret Cancer Centre
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium

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