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Fabrizio Carta

Fabrizio Carta

D-Index & Metrics

Chemistry

D-Index
62
Citations
13729
World Ranking
8818
National Ranking
237

Overview

Fabrizio Carta is affiliated with the University of Florence in Italy. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions also in the fields of chemistry and medicine. The main subfields of study involve molecular biology, organic chemistry, pharmacology, physical and theoretical chemistry, and physiology.

The scientist's work includes extensive investigation into enzyme function and inhibition, synthesis and catalytic reactions, and aspects related to cholinesterase and neurodegenerative diseases. Other key topics include phenothiazines and benzothiazines synthesis and activities, chemical reactions and mechanisms, biochemical and molecular research, as well as heme oxygenase-1 and carbon monoxide studies.

Fabrizio Carta has contributed to numerous publications in various scientific journals. Frequent venues for their work include:

  • Journal of Medicinal Chemistry
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • European Journal of Medicinal Chemistry
  • Archiv der Pharmazie
  • Molecules

Their recent papers cover topics related to enzyme inhibitors, tumor microenvironment, and drug design:

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment, 2020, Metabolites
  • Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors, 2021, Science Advances
  • Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase, 2021, Journal of Enzyme Inhibition and Medicinal Chemistry
  • Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry, 2020, Catalysts
  • Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors, 2020, Journal of Medicinal Chemistry

Collaborations have frequently involved several co-authors, notably:

  • Claudiu T. Supuran
  • Andrea Angeli
  • Simone Carradori
  • Clemente Capasso
  • Emanuela Berrino

Best Publications

  • Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

    Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia

  • Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

    Fabio Pacchiano;Fabrizio Carta;Paul C. McDonald;Yuanmei Lou

  • Antiglaucoma carbonic anhydrase inhibitors: a patent review.

    Emanuela Masini;Fabrizio Carta;Andrea Scozzafava;Claudiu T Supuran

  • Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

    Fabrizio Carta;Claudiu T Supuran

  • Antiobesity carbonic anhydrase inhibitors: a literature and patent review.

    Andrea Scozzafava;Claudiu T Supuran;Fabrizio Carta

  • Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo

    Fabrizio Carta;Mayank Aggarwal;Alfonso Maresca;Andrea Scozzafava

  • Sulfonamides: a patent review (2008 – 2012)

    Fabrizio Carta;Andrea Scozzafava;Claudiu T Supuran

  • Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

    Claudiu T. Supuran;Vincenzo Alterio;Anna Di Fiore;Katia D’ Ambrosio

  • Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

    Fabrizio Carta;Claudia Temperini;Alessio Innocenti;Andrea Scozzafava

  • Sulfonamides and their isosters as carbonic anhydrase inhibitors.

    Fabrizio Carta;Claudiu T Supuran;Andrea Scozzafava

  • Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

    Ludwig Dubois;Sarah Peeters;Natasja G. Lieuwes;Nele Geusens

  • Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

    Roben G. Gieling;Muhammad Babur;Lupti Mamnani;Natalie Burrows

  • Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

    Fabrizio Carta;Mayank Aggarwal;Alfonso Maresca;Andrea Scozzafava

  • Design and Synthesis of Novel Indole β-Diketo Acid Derivatives as HIV-1 Integrase Inhibitors

    Mario Sechi;Massimiliano Derudas;Roberto Dallocchio;Alessandro Dessì

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

    Andrea Angeli;Fabrizio Carta;Alessio Nocentini;Jean-Yves Winum

  • A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

    Fabrizio Carta;Lorenzo Di Cesare Mannelli;Melissa Pinard;Carla Ghelardini

  • Dithiocarbamates strongly inhibit the β-class carbonic anhydrases from Mycobacterium tuberculosis

    Alfonso Maresca;Fabrizio Carta;Daniela Vullo;Claudiu T. Supuran

  • Novel therapies for glaucoma: A patent review 2007 - 2011

    Fabrizio Carta;Claudiu T Supuran;Andrea Scozzafava

  • Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells.

    Tania Fiaschi;Elisa Giannoni;Maria Letizia Taddei;Paolo Cirri

  • Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

    Fabrizio Carta;Alfonso Maresca;Adrian Suarez Covarrubias;Sherry L. Mowbray

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Andrea Scozzafava
Andrea Scozzafava University of Florence
Daniela Vullo
Daniela Vullo University of Florence
Jean-Yves Winum
Jean-Yves Winum University of Montpellier
Carla Ghelardini
Carla Ghelardini University of Florence
Robert McKenna
Robert McKenna University of Florida
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine
Zeid A. ALOthman
Zeid A. ALOthman King Saud University
Seppo Parkkila
Seppo Parkkila Tampere University
Giuseppina De Simone
Giuseppina De Simone National Research Council (CNR)

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