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Wagdy M. Eldehna

Wagdy M. Eldehna

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Rising Stars
2025
Award Badge
Chemistry
Egypt
2025

D-Index & Metrics

Rising Stars

D-Index
52
Citations
7919
World Ranking
280
National Ranking
11

Chemistry

D-Index
62
Citations
9898
World Ranking
9074
National Ranking
4

Research.com Recognitions

  • 2025 - Research.com Chemistry in Egypt Leader Award
  • 2025 - Research.com Rising Stars Award
  • 2022 - Research.com Chemistry in Egypt Leader Award

Overview

Wagdy M. Eldehna is affiliated with Kafrelsheikh University in Egypt, contributing extensively to the fields of chemistry, biochemistry, genetics, and molecular biology, as well as medicine. Their research primarily spans organic chemistry, molecular biology, pharmacology, oncology, and computational theory and mathematics, with a focus on biochemical synthesis and therapeutic applications.

Their publication record includes significant work on cancer therapeutics, enzyme function, and computational drug discovery methods. Key topics in their research encompass:

  • Synthesis and biological activity
  • Enzyme function and inhibition
  • Synthesis and Catalytic Reactions
  • Cancer therapeutics and mechanisms
  • Computational Drug Discovery Methods
  • Cancer Mechanisms and Therapy
  • Synthesis and Biological Evaluation

Frequent collaborators in their research include Hatem A. Abdel-Aziz, Mahmoud A. El Hassab, Claudiu T. Supuran, Eslam B. Elkaeed, and Sara T. Al-Rashood.

Their work has been published extensively across several key scientific journals, including:

  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Bioorganic Chemistry
  • European Journal of Medicinal Chemistry
  • Molecules
  • RSC Advances

Representative recent publications by Wagdy M. Eldehna include:

  • "Recent advancements of coumarin-based anticancer agents: An up-to-date review" (2020, Bioorganic Chemistry)
  • "Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment" (2020, Metabolites)
  • "Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies" (2022, Journal of Enzyme Inhibition and Medicinal Chemistry)
  • "Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity" (2020, Journal of Enzyme Inhibition and Medicinal Chemistry)
  • "Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations" (2021, Bioorganic Chemistry)

The scientist's research contributes to a variety of study areas, including the synthesis of biologically active compounds, enzymatic inhibition, and cancer mechanisms, often integrating computational methods to refine drug discovery and therapeutic strategies.

Best Publications

  • Recent advancements of coumarin-based anticancer agents: An up-to-date review

    Tarfah Al-Warhi;Ahmed Sabt;Eslam B. Elkaeed;Wagdy M. Eldehna

  • Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies

    Wagdy M. Eldehna;Mahmoud F. Abo-Ashour;Alessio Nocentini;Paola Gratteri

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

    Andrea Angeli;Fabrizio Carta;Alessio Nocentini;Jean-Yves Winum

  • GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of a Stenocarpus sinuatus Leaves Extract

    Unknown

  • 1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.

    Sahar M. Abou-Seri;Wagdy M. Eldehna;Mamdouh M. Ali;Dalal A. Abou El Ella

  • Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents.

    Wagdy M. Eldehna;Ayman Altoukhy;Hoda Mahrous;Hatem A. Abdel-Aziz

  • Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides.

    Wagdy M Eldehna;Mohamed Fares;Marwa M Abdel-Aziz;Hatem A Abdel-Aziz;Hatem A Abdel-Aziz

  • Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

    Wagdy M. Eldehna;Mahmoud F. Abo-Ashour;Alessio Nocentini;Radwan S. El-Haggar

  • Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

    Wagdy M. Eldehna;Sahar M. Abou-Seri;Ahmed M. El Kerdawy;Rezk R. Ayyad;Rezk R. Ayyad

  • Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds.

    Hany S. Ibrahim;Wagdy M. Eldehna;Hatem A. Abdel-Aziz;Mahmoud M. Elaasser

  • Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

    Ahmed Sabt;Omaima M Abdelhafez;Radwan S El-Haggar;Hassan M F Madkour

  • Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

    Wagdy M Eldehna;Hadia Almahli;Ghada H Al-Ansary;Hazem A Ghabbour

  • 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

    Mahmoud F. Abo-Ashour;Wagdy M. Eldehna;Alessio Nocentini;Alessandro Bonardi

  • Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies.

    Unknown

  • Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations.

    Wagdy M. Eldehna;Mahmoud A. El Hassab;Mahmoud F. Abo-Ashour;Tarfah Al-Warhi

  • Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.

    Wagdy M. Eldehna;Mohamed Fares;Mariangela Ceruso;Hazem A. Ghabbour

  • Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents.

    Mahmoud F. Abo-Ashour;Wagdy M. Eldehna;Riham F. George;Marwa M. Abdel-Aziz

  • Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity.

    Sara T Al-Rashood;Ahmed R Hamed;Ghada S Hassan;Hamad M Alkahtani

  • Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies

    Wagdy M. Eldehna;Ghada H. Al-Ansary;Silvia Bua;Alessio Nocentini

  • Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation.

    Wagdy M. Eldehna;Mahmoud F. Abo-Ashour;Hany S. Ibrahim;Ghada H. Al-Ansary

  • Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

    Wagdy M. Eldehna;Ghada S. Hassan;Sara T. Al-Rashood;Tarfah Al-Warhi

  • Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

    Mohamed El-Naggar;Hadia Almahli;Hany S. Ibrahim;Wagdy M. Eldehna

Frequent Co-Authors

Hatem A. Abdel-Aziz
Hatem A. Abdel-Aziz King Saud University
Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine
Fabrizio Carta
Fabrizio Carta University of Florence
Hoong-Kun Fun
Hoong-Kun Fun Universiti Sains Malaysia
Jean-Yves Winum
Jean-Yves Winum University of Montpellier
Simone Carradori
Simone Carradori University of Chieti-Pescara
Robert McKenna
Robert McKenna University of Florida
Shoukat Dedhar
Shoukat Dedhar University of British Columbia
Zeid A. ALOthman
Zeid A. ALOthman King Saud University

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