What is she best known for?
The fields of study she is best known for:
Her primary scientific interests are in Carbonic anhydrase, Enzyme, Biochemistry, Active site and Stereochemistry.
Her Carbonic anhydrase study integrates concerns from other disciplines, such as Protein structure, Lyase and Mechanism of action.
Her Enzyme research incorporates themes from Dithiocarbamate, Small molecule and Cancer research.
Her Active site research includes elements of Cell membrane, Binding site and Sulfonamide.
Her Stereochemistry study combines topics in areas such as Nucleic acid and Heteroduplex.
Her research investigates the connection between Isozyme and topics such as Acetazolamide that intersect with problems in Gene isoform.
Her most cited work include:
- Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? (744 citations)
- Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (366 citations)
- Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (242 citations)
What are the main themes of her work throughout her whole career to date?
Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Active site are her primary areas of study.
Her work carried out in the field of Carbonic anhydrase brings together such families of science as Lyase, Sulfonamide, Isozyme, Enzyme inhibitor and Gene isoform.
Her Gene isoform research incorporates elements of Catalysis and Cytosol.
Her work on Esterase as part of general Enzyme research is frequently linked to Zonisamide, thereby connecting diverse disciplines of science.
Her Stereochemistry research is multidisciplinary, incorporating perspectives in Adduct, Molecule, Carbonic anhydrase II and Crystal structure.
Her Active site study combines topics from a wide range of disciplines, such as Zinc and Binding site.
She most often published in these fields:
- Carbonic anhydrase (45.14%)
- Biochemistry (41.71%)
- Enzyme (38.29%)
What were the highlights of her more recent work (between 2018-2021)?
- Carbonic anhydrase (45.14%)
- Enzyme (38.29%)
- Stereochemistry (30.86%)
In recent papers she was focusing on the following fields of study:
Her scientific interests lie mostly in Carbonic anhydrase, Enzyme, Stereochemistry, Biochemistry and Active site.
Her Carbonic anhydrase research is multidisciplinary, relying on both Proteoglycan, Drug target and Thiocyanate.
Her work on Enzyme family as part of general Enzyme research is often related to Plasmodium species, thus linking different fields of science.
Her research in Stereochemistry intersects with topics in Catalysis, Carbonic anhydrase II and Gene isoform.
Giuseppina De Simone combines subjects such as Marine diatom, Phaeodactylum tricornutum and Bacteria with her study of Biochemistry.
Her studies deal with areas such as Molecule and Moiety as well as Active site.
Between 2018 and 2021, her most popular works were:
- Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. (20 citations)
- Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety. (14 citations)
- Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases (11 citations)
In her most recent research, the most cited papers focused on:
Her primary areas of investigation include Carbonic anhydrase, Enzyme, Biochemistry, Trichomonas vaginalis and Gene isoform.
She has included themes like Tumor microenvironment, Carbohydrate metabolism, Transcription factor, Active site and Metabolism in her Carbonic anhydrase study.
In her study, which falls under the umbrella issue of Enzyme, Leishmaniasis and Trypanosoma is strongly linked to Microbiology.
As part of her studies on Biochemistry, Giuseppina De Simone frequently links adjacent subjects like Sulfamide.
Her Gene isoform research integrates issues from Racemic mixture, Stereochemistry and Carbonic anhydrase II.
The various areas that Giuseppina De Simone examines in her Stereochemistry study include Bicarbonate, Mutagenesis, Site-directed mutagenesis and Cytosol.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
