World's Best Scientists 2026 revealed!
Giuseppina De Simone

Giuseppina De Simone

D-Index & Metrics

Chemistry

D-Index
52
Citations
11006
World Ranking
13428
National Ranking
451

Biology and Biochemistry

D-Index
53
Citations
11157
World Ranking
16079
National Ranking
499

Giuseppina De Simone publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Giuseppina De Simone sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 175 publications — 23rd percentile

23% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Giuseppina De Simone D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Giuseppina De Simone sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 52 D-Index — 26th percentile

26% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Giuseppina De Simone is affiliated with the National Research Council (CNR) in Italy. Their research primarily focuses on enzyme function and inhibition, with extensive work in related fields such as biochemistry, genetics, molecular biology, and medicine. Their scholarly contributions span subfields including molecular biology, organic chemistry, pharmacology, hematology, and oncology.

The scientist's research addresses topics related to enzyme activity modulation, synthesis and catalytic reactions, and the biochemical pathways connected to neurodegenerative diseases and hematopoietic stem cell transplantation. Notable areas of investigation include cholinesterase and neurodegenerative diseases, chemical reactions and mechanisms, and targeted synthesis of phenothiazines and benzothiazines.

De Simone has contributed to numerous publications, with frequent appearances in prominent venues such as:

  • Blood
  • International Journal of Molecular Sciences
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • Chemical Communications

Their coauthors include several researchers with whom they have collaborated extensively. Frequent collaborators are:

  • Claudiu T. Supuran
  • Simona Maria Monti
  • Vincenzo Alterio
  • Anna Di Fiore
  • Andrea Angeli

Key publications by Giuseppina De Simone span recent years and cover topics in enzymology and cancer research. Important papers include:

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment, 2020, Metabolites
  • Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion, 2022, Journal of Experimental & Clinical Cancer Research
  • RETRACTED: A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity, 2020, International Journal of Molecular Sciences
  • Inhibition of Bone Marrow-Mesenchymal Stem Cell-Induced Carbonic Anhydrase IX Potentiates Chemotherapy Efficacy in Triple-Negative Breast Cancer Cells, 2023, Cells
  • Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity, 2024, Chemical Reviews

Their research outputs indicate a focus on carbonic anhydrase inhibitors, an important class of compounds relevant to cancer treatment and metabolic regulation. The work reflects ongoing efforts to understand enzyme targets within the tumor microenvironment and the role of these enzymes in drug resistance.

Best Publications

  • Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

    Vincenzo Alterio;Anna Di Fiore;Katia D’Ambrosio;Claudiu T. Supuran

  • Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

    Vincenzo Alterio;Mika Hilvo;Anna Di Fiore;Claudiu T. Supuran

  • Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

    Gianluca Canettieri;Lucia Di Marcotullio;Azzura Greco;Sonia Coni

  • Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

    Mika Hilvo;Lina Baranauskiene;Anna Maria Salzano;Andrea Scaloni

  • Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors.

    Giuseppina De Simone;Vincenzo Alterio;Claudiu T Supuran

  • Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

    Simona Maria Monti;Claudiu T Supuran;Giuseppina De Simone

  • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

    Giuseppina De Simone;Claudiu T. Supuran

  • In)organic anions as carbonic anhydrase inhibitors.

    Giuseppina De Simone;Claudiu T. Supuran

  • Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

    Claudiu T. Supuran;Vincenzo Alterio;Anna Di Fiore;Katia D’ Ambrosio

  • Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

    Vincenzo Alterio;Rosa Maria Vitale;Simona Maria Monti;Carlo Pedone

  • Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs

    Anna Di Fiore;Claudiu T. Supuran;Giuseppina De Simone

  • Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

    Valeria Menchise;Giuseppina De Simone;Vincenzo Alterio;Anna Di Fiore

  • Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies

    Giuseppina De Simone;Anna Di Fiore;Valeria Menchise;Carlo Pedone

  • Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex

    Valeria Menchise;Giuseppina De Simone;Tullia Tedeschi;Roberto Corradini

  • The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus.

    G De Simone;V Menchise;G Manco;L Mandrich

  • A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase.

    G De Simone;S Galdiero;G Manco;D Lang

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

    Andrea Angeli;Fabrizio Carta;Alessio Nocentini;Jean-Yves Winum

  • Antiobesity Carbonic Anhydrase Inhibitors

    Giuseppina De Simone;Claudiu T Supuran

  • X‐ray structure of the first `extremo‐α‐carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1

    Anna Di Fiore;Clemente Capasso;Viviana De Luca;Simona Maria Monti

  • Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.

    Alessio Innocenti;Andrea Scozzafava;Seppo Parkkila;Luca Puccetti

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Simona Maria Monti
Simona Maria Monti University of Naples Federico II
Carlo Pedone
Carlo Pedone University of Naples Federico II
Andrea Scozzafava
Andrea Scozzafava University of Florence
Jean-Yves Winum
Jean-Yves Winum University of Montpellier
Seppo Parkkila
Seppo Parkkila Tampere University
Daniela Vullo
Daniela Vullo University of Florence
Andrea Scaloni
Andrea Scaloni National Academies of Sciences, Engineering, and Medicine
Mosè Rossi
Mosè Rossi National Research Council (CNR)
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine

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