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Giuseppina De Simone

Giuseppina De Simone

D-Index & Metrics

Chemistry

D-Index
52
Citations
11006
World Ranking
13430
National Ranking
451

Biology and Biochemistry

D-Index
53
Citations
11157
World Ranking
16086
National Ranking
500

Overview

Giuseppina De Simone is affiliated with the National Research Council (CNR) in Italy. Their research primarily focuses on enzyme function and inhibition, with extensive work in related fields such as biochemistry, genetics, molecular biology, and medicine. Their scholarly contributions span subfields including molecular biology, organic chemistry, pharmacology, hematology, and oncology.

The scientist's research addresses topics related to enzyme activity modulation, synthesis and catalytic reactions, and the biochemical pathways connected to neurodegenerative diseases and hematopoietic stem cell transplantation. Notable areas of investigation include cholinesterase and neurodegenerative diseases, chemical reactions and mechanisms, and targeted synthesis of phenothiazines and benzothiazines.

De Simone has contributed to numerous publications, with frequent appearances in prominent venues such as:

  • Blood
  • International Journal of Molecular Sciences
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • Chemical Communications

Their coauthors include several researchers with whom they have collaborated extensively. Frequent collaborators are:

  • Claudiu T. Supuran
  • Simona Maria Monti
  • Vincenzo Alterio
  • Anna Di Fiore
  • Andrea Angeli

Key publications by Giuseppina De Simone span recent years and cover topics in enzymology and cancer research. Important papers include:

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment, 2020, Metabolites
  • Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion, 2022, Journal of Experimental & Clinical Cancer Research
  • RETRACTED: A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity, 2020, International Journal of Molecular Sciences
  • Inhibition of Bone Marrow-Mesenchymal Stem Cell-Induced Carbonic Anhydrase IX Potentiates Chemotherapy Efficacy in Triple-Negative Breast Cancer Cells, 2023, Cells
  • Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity, 2024, Chemical Reviews

Their research outputs indicate a focus on carbonic anhydrase inhibitors, an important class of compounds relevant to cancer treatment and metabolic regulation. The work reflects ongoing efforts to understand enzyme targets within the tumor microenvironment and the role of these enzymes in drug resistance.

Best Publications

  • Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

    Vincenzo Alterio;Anna Di Fiore;Katia D’Ambrosio;Claudiu T. Supuran

  • Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

    Vincenzo Alterio;Mika Hilvo;Anna Di Fiore;Claudiu T. Supuran

  • Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

    Gianluca Canettieri;Lucia Di Marcotullio;Azzura Greco;Sonia Coni

  • Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

    Mika Hilvo;Lina Baranauskiene;Anna Maria Salzano;Andrea Scaloni

  • Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors.

    Giuseppina De Simone;Vincenzo Alterio;Claudiu T Supuran

  • Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

    Simona Maria Monti;Claudiu T Supuran;Giuseppina De Simone

  • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

    Giuseppina De Simone;Claudiu T. Supuran

  • In)organic anions as carbonic anhydrase inhibitors.

    Giuseppina De Simone;Claudiu T. Supuran

  • Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

    Claudiu T. Supuran;Vincenzo Alterio;Anna Di Fiore;Katia D’ Ambrosio

  • Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

    Vincenzo Alterio;Rosa Maria Vitale;Simona Maria Monti;Carlo Pedone

  • Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs

    Anna Di Fiore;Claudiu T. Supuran;Giuseppina De Simone

  • Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

    Valeria Menchise;Giuseppina De Simone;Vincenzo Alterio;Anna Di Fiore

  • Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies

    Giuseppina De Simone;Anna Di Fiore;Valeria Menchise;Carlo Pedone

  • Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex

    Valeria Menchise;Giuseppina De Simone;Tullia Tedeschi;Roberto Corradini

  • The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus.

    G De Simone;V Menchise;G Manco;L Mandrich

  • A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase.

    G De Simone;S Galdiero;G Manco;D Lang

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

    Andrea Angeli;Fabrizio Carta;Alessio Nocentini;Jean-Yves Winum

  • Antiobesity Carbonic Anhydrase Inhibitors

    Giuseppina De Simone;Claudiu T Supuran

  • X‐ray structure of the first `extremo‐α‐carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1

    Anna Di Fiore;Clemente Capasso;Viviana De Luca;Simona Maria Monti

  • Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.

    Alessio Innocenti;Andrea Scozzafava;Seppo Parkkila;Luca Puccetti

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Simona Maria Monti
Simona Maria Monti University of Naples Federico II
Carlo Pedone
Carlo Pedone University of Naples Federico II
Andrea Scozzafava
Andrea Scozzafava University of Florence
Jean-Yves Winum
Jean-Yves Winum University of Montpellier
Seppo Parkkila
Seppo Parkkila Tampere University
Daniela Vullo
Daniela Vullo University of Florence
Andrea Scaloni
Andrea Scaloni National Academies of Sciences, Engineering, and Medicine
Mosè Rossi
Mosè Rossi National Research Council (CNR)
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine

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