Enzyme, Carbonic anhydrase, Biochemistry, Isozyme and Enzyme inhibitor are his primary areas of study. His research integrates issues of Glycosyl, Bicarbonate and Cancer in his study of Enzyme. The Carbonic anhydrase study combines topics in areas such as Carbonic Anhydrase IX, Pathogen, Chemical synthesis and Stereochemistry.
His studies in Stereochemistry integrate themes in fields like Adduct and Active site. His biological study spans a wide range of topics, including Carcinogenesis, Zinc and Drug. His research integrates issues of Structure–activity relationship, Sulfonamide and Carbonic anhydrase inhibitor in his study of Isozyme.
His primary scientific interests are in Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Isozyme. In his study, which falls under the umbrella issue of Carbonic anhydrase, Combinatorial chemistry is strongly linked to Sulfonamide. His biological study spans a wide range of topics, including Cancer and Sulfonamide.
Within one scientific family, Jean-Yves Winum focuses on topics pertaining to Chemical synthesis under Enzyme, and may sometimes address concerns connected to Triazine. He has included themes like Medicinal chemistry, Lyase, Carbonic anhydrase II, Transmembrane protein and Adduct in his Stereochemistry study. Jean-Yves Winum combines subjects such as Extracellular, Structure–activity relationship, Carbonic anhydrase inhibitor and Sulfamic acid with his study of Isozyme.
His primary areas of study are Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Portuguese. His Carbonic anhydrase research is multidisciplinary, incorporating elements of Cancer cell, Lyase, Combinatorial chemistry and Active site. His study in Biochemistry is interdisciplinary in nature, drawing from both Thiourea and Toxicity.
The concepts of his Enzyme study are interwoven with issues in Pathogen, Antibiotics, Microbiology, Sulfonamide and Drug. His work deals with themes such as Reagent, Carbonic Anhydrase I, Crystal structure and Sulfamide, which intersect with Stereochemistry. The Normal tissue study combines topics in areas such as Cancer research and Isozyme.
Jean-Yves Winum mostly deals with Carbonic anhydrase, Biochemistry, Enzyme, Lyase and Cancer cell. His research in Carbonic anhydrase focuses on subjects like Active site, which are connected to Metal, Cyanate, Drug and Candida glabrata. His research ties Toxicity and Biochemistry together.
Jean-Yves Winum interconnects Combinatorial chemistry, Pathogen, In vitro and Sulfonamide in the investigation of issues within Enzyme. His work in Lyase tackles topics such as Stereochemistry which are related to areas like Crystallography, Crystal structure, Protein structure and Derivative. His Cancer cell study integrates concerns from other disciplines, such as Cancer research, Angiogenesis, Tumor microenvironment, Carbohydrate metabolism and Metabolism.
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Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia.
Cancer Research (2011)
Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.
Paul C. McDonald;Jean-Yves Winum;Claudiu T. Supuran;Shoukat Dedhar.
Oncotarget (2012)
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.
F.E.a Lock;P.C.a McDonald;Y.a Lou;I.a Serrano.
Oncogene (2013)
Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors†
Alessandro Cecchi;Alzbeta Hulikova;Jaromír Pastorek;Silvia Pastoreková.
Journal of Medicinal Chemistry (2005)
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.
Jean-Yves Winum;Marouan Rami;Andrea Scozzafava;Jean-Louis Montero.
Medicinal Research Reviews (2008)
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.
Nadia Touisni;Alfonso Maresca;Paul C. McDonald;Yuanmei Lou.
Journal of Medicinal Chemistry (2011)
Sulfamates and their therapeutic potential
Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran.
Medicinal Research Reviews (2005)
Therapeutic potential of sulfamides as enzyme inhibitors.
Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran.
Medicinal Research Reviews (2006)
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
‡ Jean-Yves Winum;Claudia Temperini;Khaled El Cheikh;Alessio Innocenti.
Journal of Medicinal Chemistry (2006)
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Vladimir Garaj;Luca Puccetti;Giuseppe Fasolis;Jean-Yves Winum;Jean-Yves Winum.
Bioorganic & Medicinal Chemistry Letters (2005)
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