D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 56 Citations 9,058 198 World Ranking 8235 National Ranking 280

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Biochemistry

Enzyme, Carbonic anhydrase, Biochemistry, Isozyme and Enzyme inhibitor are his primary areas of study. His research integrates issues of Glycosyl, Bicarbonate and Cancer in his study of Enzyme. The Carbonic anhydrase study combines topics in areas such as Carbonic Anhydrase IX, Pathogen, Chemical synthesis and Stereochemistry.

His studies in Stereochemistry integrate themes in fields like Adduct and Active site. His biological study spans a wide range of topics, including Carcinogenesis, Zinc and Drug. His research integrates issues of Structure–activity relationship, Sulfonamide and Carbonic anhydrase inhibitor in his study of Isozyme.

His most cited work include:

  • Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors (484 citations)
  • Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. (297 citations)
  • Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. (227 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Isozyme. In his study, which falls under the umbrella issue of Carbonic anhydrase, Combinatorial chemistry is strongly linked to Sulfonamide. His biological study spans a wide range of topics, including Cancer and Sulfonamide.

Within one scientific family, Jean-Yves Winum focuses on topics pertaining to Chemical synthesis under Enzyme, and may sometimes address concerns connected to Triazine. He has included themes like Medicinal chemistry, Lyase, Carbonic anhydrase II, Transmembrane protein and Adduct in his Stereochemistry study. Jean-Yves Winum combines subjects such as Extracellular, Structure–activity relationship, Carbonic anhydrase inhibitor and Sulfamic acid with his study of Isozyme.

He most often published in these fields:

  • Carbonic anhydrase (53.88%)
  • Biochemistry (46.98%)
  • Enzyme (43.53%)

What were the highlights of his more recent work (between 2015-2021)?

  • Carbonic anhydrase (53.88%)
  • Biochemistry (46.98%)
  • Enzyme (43.53%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Portuguese. His Carbonic anhydrase research is multidisciplinary, incorporating elements of Cancer cell, Lyase, Combinatorial chemistry and Active site. His study in Biochemistry is interdisciplinary in nature, drawing from both Thiourea and Toxicity.

The concepts of his Enzyme study are interwoven with issues in Pathogen, Antibiotics, Microbiology, Sulfonamide and Drug. His work deals with themes such as Reagent, Carbonic Anhydrase I, Crystal structure and Sulfamide, which intersect with Stereochemistry. The Normal tissue study combines topics in areas such as Cancer research and Isozyme.

Between 2015 and 2021, his most popular works were:

  • Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018). (45 citations)
  • Benzoxaborole as a new chemotype for carbonic anhydrase inhibition. (38 citations)
  • Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles (27 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Biochemistry

Jean-Yves Winum mostly deals with Carbonic anhydrase, Biochemistry, Enzyme, Lyase and Cancer cell. His research in Carbonic anhydrase focuses on subjects like Active site, which are connected to Metal, Cyanate, Drug and Candida glabrata. His research ties Toxicity and Biochemistry together.

Jean-Yves Winum interconnects Combinatorial chemistry, Pathogen, In vitro and Sulfonamide in the investigation of issues within Enzyme. His work in Lyase tackles topics such as Stereochemistry which are related to areas like Crystallography, Crystal structure, Protein structure and Derivative. His Cancer cell study integrates concerns from other disciplines, such as Cancer research, Angiogenesis, Tumor microenvironment, Carbohydrate metabolism and Metabolism.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia.
Cancer Research (2011)

666 Citations

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.

Paul C. McDonald;Jean-Yves Winum;Claudiu T. Supuran;Shoukat Dedhar.
Oncotarget (2012)

402 Citations

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

F.E.a Lock;P.C.a McDonald;Y.a Lou;I.a Serrano.
Oncogene (2013)

379 Citations

Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors†

Alessandro Cecchi;Alzbeta Hulikova;Jaromír Pastorek;Silvia Pastoreková.
Journal of Medicinal Chemistry (2005)

299 Citations

Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

Jean-Yves Winum;Marouan Rami;Andrea Scozzafava;Jean-Louis Montero.
Medicinal Research Reviews (2008)

254 Citations

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

Nadia Touisni;Alfonso Maresca;Paul C. McDonald;Yuanmei Lou.
Journal of Medicinal Chemistry (2011)

248 Citations

Sulfamates and their therapeutic potential

Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran.
Medicinal Research Reviews (2005)

219 Citations

Therapeutic potential of sulfamides as enzyme inhibitors.

Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran.
Medicinal Research Reviews (2006)

189 Citations

Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

‡ Jean-Yves Winum;Claudia Temperini;Khaled El Cheikh;Alessio Innocenti.
Journal of Medicinal Chemistry (2006)

184 Citations

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Vladimir Garaj;Luca Puccetti;Giuseppe Fasolis;Jean-Yves Winum;Jean-Yves Winum.
Bioorganic & Medicinal Chemistry Letters (2005)

179 Citations

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