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Chemistry

D-Index
61
Citations
11564
World Ranking
9374
National Ranking
336

Overview

Jean-Yves Winum is affiliated with the University of Montpellier in France. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, as well as Chemistry. Within these domains, they have contributed notably to subfields such as Molecular Biology, Organic Chemistry, Developmental and Educational Psychology, Materials Chemistry, and Information Systems.

Winum's work addresses a variety of topics, prominently featuring enzyme function and inhibition, synthesis and catalytic reactions, as well as educational games and gamification. Additional topics include mobile learning in education, teaching and learning programming, cholinesterase and neurodegenerative diseases, and nanoplatforms for cancer theranostics.

Recent papers authored or co-authored by Winum include the following:

  • The importance of sulfur-containing motifs in drug design and discovery, 2022, Expert Opinion on Drug Discovery
  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment, 2020, Metabolites
  • Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase, 2021, Journal of Enzyme Inhibition and Medicinal Chemistry
  • RETRACTED: A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity, 2020, International Journal of Molecular Sciences
  • Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies, 2020, Cells

Frequent co-authors collaborating with Winum include Claudiu T. Supuran, Alessio Nocentini, Antônio José Melo Leite, José Nunes da Silva, and Sébastien Clément.

Winum's contributions are regularly published in several key journals, including Journal of Chemical Education, The Cambridge Structural Database, Expert Opinion on Therapeutic Patents, Journal of Medicinal Chemistry, and Cancer Research.

In addition to research articles, Winum has authored several books published by the Centre National de la Recherche Scientifique. These include "Chimie organique expérimentale: L'essentiel pour l'étudiant" (2022), "Chimie - 2e éd. Les manuels visuels pour la licence" (2021), "Mémo visuel de chimie générale - 2e édition" (2022), and "Structure des molécules organiques: l'essentiel pour l'étudiant" (2024).

Best Publications

  • Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

    Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia

  • Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.

    Paul C. McDonald;Jean-Yves Winum;Claudiu T. Supuran;Shoukat Dedhar

  • Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

    F.E.a Lock;P.C.a McDonald;Y.a Lou;I.a Serrano

  • Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors†

    Alessandro Cecchi;Alzbeta Hulikova;Jaromír Pastorek;Silvia Pastoreková

  • Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

    Jean-Yves Winum;Marouan Rami;Andrea Scozzafava;Jean-Louis Montero

  • Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

    Nadia Touisni;Alfonso Maresca;Paul C. McDonald;Yuanmei Lou

  • Sulfamates and their therapeutic potential

    Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

    Arduino A. Mangoni;Catherine Guillou;Jean Jacques Vanden Eynde;Christopher Hulme

  • Therapeutic potential of sulfamides as enzyme inhibitors.

    Jean-Yves Winum;Andrea Scozzafava;Jean-Louis Montero;Claudiu T. Supuran

  • Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

    Vladimir Garaj;Luca Puccetti;Giuseppe Fasolis;Jean-Yves Winum;Jean-Yves Winum

  • Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

    ‡ Jean-Yves Winum;Claudia Temperini;Khaled El Cheikh;Alessio Innocenti

  • Drug design of Zinc-enzyme inhibitors: functional, structural and disease applications

    Claudiu T. Supuran;Jean-Yves Winum

  • Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.

    † Jean-Yves Winum;Daniela Vullo;Angela Casini;† Jean-Louis Montero

  • Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

    Roben G. Gieling;Muhammad Babur;Lupti Mamnani;Natalie Burrows

  • Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.

    Francesco Abbate;Jean-Yves Winum;Barry V.L. Potter;Angela Casini

  • Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

    Andrea Angeli;Fabrizio Carta;Alessio Nocentini;Jean-Yves Winum

  • Carbonic anhydrase IX inhibitors in cancer therapy: an update

    Claudiu T Supuran;Jean-Yves Winum

  • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.

    Vladimir Garaj;Luca Puccetti;Giuseppe Fasolis;Jean-Yves Winum;Jean-Yves Winum

  • Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.

    Adeline Bonneau;Alfonso Maresca;Jean-Yves Winum;Claudiu T. Supuran

  • Therapeutic applications of glycosidic carbonic anhydrase inhibitors

    Jean-Yves Winum;Sally-Ann Poulsen;Claudiu T. Supuran

  • Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

    Giuseppina De Simone;Rosa Maria Vitale;Anna Di Fiore;Carlo Pedone

Frequent Co-Authors

Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Andrea Scozzafava
Andrea Scozzafava University of Florence
Daniela Vullo
Daniela Vullo University of Florence
Alessio Innocenti
Alessio Innocenti University of Florence
Fabrizio Carta
Fabrizio Carta University of Florence
Giuseppina De Simone
Giuseppina De Simone National Research Council (CNR)
Pascal Dumy
Pascal Dumy École Nationale Supérieure de Chimie de Montpellier
Philippe Lambin
Philippe Lambin Maastricht University
Simona Maria Monti
Simona Maria Monti University of Naples Federico II
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine

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