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Biology and Biochemistry

D-Index
70
Citations
27947
World Ranking
6861
National Ranking
3166

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Daniel S. Ory is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, focusing notably on subfields such as Molecular Biology, Physiology, Genetics, Surgery, and Biochemistry.

The body of research conducted includes contributions to several key topics, including:

  • Lysosomal Storage Disorders Research
  • RNA regulation and disease
  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • Cholesterol and Lipid Metabolism
  • Lipid metabolism and biosynthesis
  • Peroxisome Proliferator-Activated Receptors

They have frequently published in journals such as Journal of Lipid Research, Nature Communications, Journal of Clinical Investigation, Gene Therapy, and Molecular Therapy, with multiple publications in select venues:

  • Journal of Lipid Research (3 publications)
  • Nature Communications (2 publications)
  • Journal of Clinical Investigation
  • Gene Therapy
  • Molecular Therapy

Selected recent papers include:

  • "Krabbe disease successfully treated via monotherapy of intrathecal gene therapy" (2020, Journal of Clinical Investigation)
  • "A novel gene editing system to treat both Tay-Sachs and Sandhoff diseases" (2020, Gene Therapy)
  • "Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease" (2020, Molecular Therapy)
  • "Circulating ceramide ratios and risk of vascular brain aging and dementia" (2020, Annals of Clinical and Translational Neurology)
  • "Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment" (2020, Journal of Lipid Research)

Frequent collaborators include:

  • Xuntian Jiang
  • Jean E. Schaffer
  • Rohini Sidhu
  • Sarah E. Gale
  • Mingxing Qian

Throughout their career, Daniel S. Ory has been recognized with awards such as the Fellow of the American Association for the Advancement of Science (AAAS) in 2008, and membership in the Association of American Physicians.

Best Publications

  • In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

    Luigi Naldini;Ulrike Blömer;Philippe Gallay;Daniel Ory

  • Triglyceride accumulation protects against fatty acid-induced lipotoxicity

    Laura L. Listenberger;Xianlin Han;Sarah E. Lewis;Sylvaine Cases

  • A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes

    Daniel S. Ory;Beverly A. Neugeboren;Richard C. Mulligan

  • Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

    Marceline Côté;John Misasi;John Misasi;Tao Ren;Anna Bruchez

  • Palmitate-induced apoptosis can occur through a ceramide-independent pathway.

    Laura L. Listenberger;Daniel S. Ory;Jean E. Schaffer

  • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

    Nica M. Borradaile;Xianlin Han;Jeffrey D. Harp;Sarah E. Gale

  • miR-33 links SREBP-2 induction to repression of sterol transporters

    Tyler J. Marquart;Ryan M. Allen;Daniel S. Ory;Ángel Baldán

  • Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy

    Hsiu-Chiang Chiu;Attila Kovacs;Robert M. Blanton;Xianlin Han

  • Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression

    Cristin D. Davidson;Nafeeza F. Ali;Matthew C. Micsenyi;Gloria Stephney

  • Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells

    Chung-Fang Lai;Lala Chaudhary;Aurora Fausto;Linda R. Halstead

  • Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex

    Brian M. Castellano;Ashley M. Thelen;Ofer Moldavski;McKenna Feltes

  • Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease

    Forbes D. Porter;David E. Scherrer;Michael H. Lanier;S. Joshua Langmade

  • Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

    Daniel S Ory;Elizabeth A Ottinger;Nicole Yanjanin Farhat;Kelly A King

  • A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma

    Xuntian Jiang;Rohini Sidhu;Forbes D. Porter;Nicole M. Yanjanin

  • Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

    Xiaochao Wei;Haowei Song;Li Yin;Michael G. Rizzo

  • Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration

    Abdoulaye Sene;Aslam A. Khan;Douglas Cox;Rei E.I. Nakamura

  • NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

    Andrey Frolov;Sarah E. Zielinski;Jan R. Crowley;Nicole Dudley-Rucker

  • Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

    Carlos I. Michel;Christopher L. Holley;Benjamin S. Scruggs;Rohini Sidhu

  • Consensus clinical management guidelines for Niemann-Pick disease type C.

    Tarekegn Geberhiwot;Alessandro Moro;Andrea Dardis;Uma Ramaswami

  • ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.

    Chun Yan Lim;Oliver B. Davis;Hijai R. Shin;Justin Zhang

Frequent Co-Authors

Jean E. Schaffer
Jean E. Schaffer Harvard University
Forbes D. Porter
Forbes D. Porter National Institutes of Health
Douglas F. Covey
Douglas F. Covey Washington University in St. Louis
Steven U. Walkley
Steven U. Walkley Albert Einstein College of Medicine
Paul H. Schlesinger
Paul H. Schlesinger Washington University in St. Louis
Jean-François Guillemoles
Jean-François Guillemoles Centre national de la recherche scientifique, CNRS
Mark S. Sands
Mark S. Sands Washington University in St. Louis
William J. Pavan
William J. Pavan National Institutes of Health
Nathan A. Baker
Nathan A. Baker Pacific Northwest National Laboratory
Xianlin Han
Xianlin Han The University of Texas Health Science Center at San Antonio

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