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Molecular Biology
Italy
2026
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Genetics and Molecular Biology
Italy
2024

D-Index & Metrics

Molecular Biology

D-Index
131
Citations
78692
World Ranking
181
National Ranking
3

Medicine

D-Index
133
Citations
79534
World Ranking
2199
National Ranking
45

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Italy Leader Award
  • 2025 - Research.com Molecular Biology in Italy Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • 2023 - Research.com Molecular Biology in Italy Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Luigi Naldini is affiliated with Vita-Salute San Raffaele University in Italy. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular biology, genetics, immunology, oncology, and physiology. The scientist has contributed extensively to virus-based gene therapy, CRISPR and genetic engineering, CAR-T cell therapy, immune cells in cancer, extracellular vesicles in disease, glioma diagnosis and treatment, and pluripotent stem cells research.

Naldini's most frequently published work appears in journals such as Blood, Molecular Therapy, Science Translational Medicine, Neuro-Oncology, and HemaSphere, with multiple publications across these venues.

Recent papers authored by Naldini or involving collaborations include:

  • ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update, 2021, Stem Cell Reports
  • Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access, 2022, The Lancet
  • IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer, 2023, Nature
  • Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking, 2020, Nature Biotechnology
  • Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress, 2022, Nature Immunology

Frequent co-authors collaborating with Naldini include Bernhard Gentner, Fabio Ciceri, Alessandro Aiuti, Ivan Merelli, and Samuele Ferrari.

Their research topics incorporate:

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Extracellular vesicles in disease
  • Glioma Diagnosis and Treatment
  • Pluripotent Stem Cells Research

Naldini has been recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

    Luigi Naldini;Ulrike Blömer;Philippe Gallay;Daniel Ory

  • A Third-Generation Lentivirus Vector with a Conditional Packaging System

    Tom Dull;Romain Zufferey;Michael Kelly;R. J. Mandel

  • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

    Romain Zufferey;Dea Nagy;Ron J. Mandel;Luigi Naldini

  • Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

    Romain Zufferey;Thomas Dull;Ronald J. Mandel;Anatoly Bukovsky

  • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

    Luigi Naldini;Ulrike Blomer;Fred H. Gage;Didier Trono

  • Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

    Mark A. Kay;Joseph C Glorioso;Luigi Naldini

  • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

    F Bussolino;M F Di Renzo;M Ziche;E Bocchietto

  • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

    Michele De Palma;Mary Anna Venneri;Rossella Galli;Lucia Sergi Sergi

  • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences.

    Antonia Follenzi;Laurie E. Ailles;Silvia Bakovic;Massimo Geuna

  • Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.

    Alessandra Biffi;Eugenio Montini;Laura Lorioli;Martina Cesani

  • Gene therapy returns to centre stage

    Luigi Naldini

  • Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

    Alessandro Aiuti;Luca Biasco;Samantha Scaramuzza;Francesca Ferrua

  • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

    A. Lombardo;A. Lombardo;P. Genovese;P. Genovese;C.M. Beausejour;C.M. Beausejour;S. Colleoni;S. Colleoni

  • Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector.

    Ulrike Blömer;Luigi Naldini;Tal Kafri;Didier Trono

  • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

    L Naldini;E Vigna;R P Narsimhan;G Gaudino

  • Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

    Eugenio Montini;Daniela Cesana;Manfred Schmidt;Francesca Sanvito

  • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

    L. Naldini;K.M. Weidner;E. Vigna;G. Gaudino

  • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

    Luigi Naldini;Luca Tamagnone;Elisa Vigna;Martin Sachs

  • Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

    Roberta Mazzieri;Ferdinando Pucci;Davide Moi;Erika Zonari

  • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.

    Michele De Palma;Mary Anna Venneri;Cristina Roca;Luigi Naldini

Frequent Co-Authors

Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University
Alessandro Aiuti
Alessandro Aiuti Vita-Salute San Raffaele University
Eugenio Montini
Eugenio Montini IRCCS Ospedale San Raffaele
Fabio Ciceri
Fabio Ciceri Vita-Salute San Raffaele University
Paolo M. Comoglio
Paolo M. Comoglio FIRC Institute of Molecular Oncology
Michael C. Holmes
Michael C. Holmes Ambys Medicines
Claudio Bordignon
Claudio Bordignon MolMed (Italy)
Antonia Follenzi
Antonia Follenzi University of Eastern Piedmont Amadeo Avogadro
Michele De Palma
Michele De Palma École Polytechnique Fédérale de Lausanne
Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)

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