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51
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Overview

Eugenio Montini is affiliated with IRCCS Ospedale San Raffaele in Italy and conducts research primarily within the fields of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Medicine. Their work spans several subfields including Molecular Biology, Genetics, Oncology, Hematology, and Physiology.

Montini's publications explore significant topics such as virus-based gene therapy research, CRISPR and genetic engineering, CAR-T cell therapy research, viral infectious diseases and gene expression in insects, viral gastroenteritis research and epidemiology, pluripotent stem cells research, and RNA interference and gene delivery.

The scientist has contributed to numerous peer-reviewed articles, with recent notable papers including:

  • "Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities" (2020, Journal of Clinical Investigation)
  • "Evaluating the state of the science for adeno-associated virus integration: An integrated perspective" (2022, Molecular Therapy)
  • "Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells" (2022, Cell Stem Cell)
  • "AAV integration in human hepatocytes" (2021, Molecular Therapy)
  • "Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia" (2023, Nature Communications)

Frequent co-authors of Eugenio Montini include Andrea Calabria, Alessandro Aiuti, Fabrizio Benedicenti, Luigi Naldini, and Ivan Merelli, reflecting collaborations that have contributed to various aspects of gene therapy and molecular biology research.

Montini has published extensively in several journals, appearing most frequently in Molecular Therapy and Nature Communications, each with seven publications, followed by Blood and Journal of Applied Cosmetology with six publications each, and Molecular Genetics and Metabolism with four publications.

The research topics span advanced therapeutic methods, including gene editing and cell therapy approaches targeting oncology and hematology conditions. Studies on viral vector integration and safety profiles in gene therapy highlight Montini's involvement in understanding and optimizing genetic engineering techniques.

Best Publications

  • Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.

    Alessandra Biffi;Eugenio Montini;Laura Lorioli;Martina Cesani

  • Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

    Alessandro Aiuti;Luca Biasco;Samantha Scaramuzza;Francesca Ferrua

  • Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

    Eugenio Montini;Daniela Cesana;Manfred Schmidt;Francesca Sanvito

  • Targeted genome editing in human repopulating haematopoietic stem cells

    Pietro Genovese;Giulia Schiroli;Giulia Escobar;Tiziano Di Tomaso

  • The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

    Eugenio Montini;Daniela Cesana;Manfred Schmidt;Francesca Sanvito

  • Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial

    Maria Sessa;Laura Lorioli;Francesca Fumagalli;Serena Acquati

  • AAV serotype 2 vectors preferentially integrate into active genes in mice

    Hiroyuki Nakai;Eugenio Montini;Sally Fuess;Theresa A Storm

  • Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.

    Siniša Volarević;Mary J. Stewart;Birgit Ledermann;Frederic Zilberman

  • Kinetics of liver repopulation after bone marrow transplantation.

    Xin Wang;Eugenio Montini;Muhsen Al-Dhalimy;Eric Lagasse

  • Functional implications of the spectrum of mutations found in 234 cases with X-linked juvenile retinoschisis (XLRS)

    J.T. Dendunnen;T. Kraayenbrink;T. Kraayenbrink;M. van Schooneveld;M. van Schooneveld;E. van de Vosse

  • Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

    Alessandra Biffi;Cynthia C. Bartolomae;Daniela Cesana;Natalie Cartier

  • Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

    Giulia Schiroli;Anastasia Conti;Samuele Ferrari;Lucrezia della Volpe

  • Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver

    Hiroyuki Nakai;Xiaolin Wu;Sally Fuess;Theresa A. Storm

  • Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells.

    Michele De Palma;Eugenio Montini;Francesca R Santoni de Sio;Fabrizio Benedicenti

  • Comprehensive genomic access to vector integration in clinical gene therapy

    Richard Gabriel;Ralph Eckenberg;Anna Paruzynski;Cynthia C Bartholomae

  • Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo.

    Daniela Cesana;Marco Ranzani;Monica Volpin;Cynthia Bartholomae

  • Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.

    Sarah Marktel;Samantha Scaramuzza;Maria Pia Cicalese;Fabio Giglio

  • Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

    Alessia Capotondo;Rita Milazzo;Letterio Salvatore Politi;Angelo Quattrini

  • In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.

    Luca Biasco;Serena Scala;Luca Basso Ricci;Francesca Dionisio

  • In vivo correction of murine tyrosinemia type I by DNA-mediated transposition

    Eugenio Montini;Patrice K. Held;Meenakshi Noll;Nicolas Morcinek

Frequent Co-Authors

Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Alessandro Aiuti
Alessandro Aiuti Vita-Salute San Raffaele University
Claudio Doglioni
Claudio Doglioni Vita-Salute San Raffaele University
Fabio Ciceri
Fabio Ciceri Vita-Salute San Raffaele University
Markus Grompe
Markus Grompe Oregon Health & Science University
Christof von Kalle
Christof von Kalle Charité - University Medicine Berlin
Manfred Schmidt
Manfred Schmidt German Cancer Research Center
Fulvio Mavilio
Fulvio Mavilio University of Modena and Reggio Emilia
Andrea Biondi
Andrea Biondi University of Milano-Bicocca
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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