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D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
23240
World Ranking
4519
National Ranking
2199

Overview

Allan E. Rettie is affiliated with the University of Washington in the United States and specializes in the field of Pharmacology, Toxicology and Pharmaceutics. Their research spans multiple subfields, including Pharmacology, Health, Toxicology and Mutagenesis, Biochemistry, Computational Theory and Mathematics, and Nutrition and Dietetics.

The primary focus of Rettie's work includes Pharmacogenetics and Drug Metabolism, Effects and risks of endocrine disrupting chemicals, Computational Drug Discovery Methods, Receptor Mechanisms and Signaling, Vitamin K Research Studies, Alkaloids synthesis and pharmacology, and Carcinogens and Genotoxicity Assessment.

Rettie has contributed to various publication venues throughout their career. Frequent venues include:

  • International Journal of Toxicology
  • Drug Metabolism and Disposition
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pharmacology and Experimental Therapeutics
  • Clinical and Translational Science

Frequent co-authors who have collaborated with Rettie often appear in their publications, including Wilma F. Bergfeld, D. Belsito, David E. Cohen, Curtis D. Klaassen, and Thomas J. Slaga.

Among recent papers authored or co-authored by Rettie are:

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update (2020), published in Clinical Pharmacology & Therapeutics
  • Massively parallel characterization of CYP2C9 variant enzyme activity and abundance (2021), published in The American Journal of Human Genetics
  • Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact (2020), published in eLife
  • Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants (2022), published in Pharmaceutics
  • Microphysiological system modeling of ochratoxin A-associated nephrotoxicity (2020), published in Toxicology

Best Publications

  • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.

    Mark J. Rieder;Alexander P. Reiner;Brian F. Gage;Deborah A. Nickerson

  • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.

    Mitchell K. Higashi;David L. Veenstra;L. Midori Kondo;Ann K. Wittkowsky

  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

    Mary F. Paine;Heather L. Hart;Shana S. Ludington;Robert L. Haining

  • Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin

    BF Gage;C Eby;JA Johnson;E Deych

  • Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

    A E Rettie;K R Korzekwa;K L Kunze;R F Lawrence

  • Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites.

    K R Korzekwa;N Krishnamachary;M Shou;A Ogai

  • Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9.

    Allan E. Rettie;Larry C. Wienkers;Frank J. Gonzalez;William F. Trager

  • A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

    Gregory M. Cooper;Julie A. Johnson;Taimour Y. Langaee;Hua Feng

  • CYP4F2 IS A VITAMIN K1 OXIDASE: AN EXPLANATION FOR ALTERED WARFARIN DOSE IN CARRIERS OF THE V433M VARIANT

    Matthew G. McDonald;Mark J. Rieder;Mariko Nakano;Clara K. Hsia

  • Genetic association between sensitivity to warfarin and expression of CYP2C9*3

    Daniel J. Steward;Robert L. Haining;Kirk R. Henne;George Davis

  • Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

    Robert L. Haining;Ann P. Hunter;Maurice E. Veronese;William F. Trager

  • Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans.

    Leslie J. Dickmann;Allan E. Rettie;M. Byron Kneller;Richard B. Kim

  • CLINICAL AND TOXICOLOGICAL RELEVANCE OF CYP2C9: Drug-Drug Interactions and Pharmacogenetics

    Allan E. Rettie;Jeffrey P. Jones

  • Developmental expression of human hepatic CYP2C9 and CYP2C19.

    Sevasti B. Koukouritaki;Jason R. Manro;Sandra A. Marsh;Jeffrey C. Stevens

  • Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

    Allan E. Rettie;Albert W. Rettenmeier;William N. Howald;Thomas A. Baillie

  • Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

    Dieter H. Lang;Catherine K. Yeung;Raimund M. Peter;Catherine Ibarra

  • In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development

    S A Wrighton;M Vandenbranden;J C Stevens;L A Shipley

  • Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance.

    Rheem A. Totah;Allan E. Rettie

  • Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

    Weiqiao Chen;Luke L. Koenigs;Stella J. Thompson;Raimund M. Peter

  • Use of Pharmacogenetics and Clinical Factors To Predict the Maintenance Dose of Warfarin.

    B. F. Gage;C. S. Eby;J. A. Johnson;M. J. Rieder

Frequent Co-Authors

William F. Trager
William F. Trager University of Washington
Mark J. Rieder
Mark J. Rieder University of Washington
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
Helmut Hanenberg
Helmut Hanenberg University of Duisburg-Essen
Jeffrey P. Jones
Jeffrey P. Jones Washington State University
Timothy A. Thornton
Timothy A. Thornton University of Washington
Andrea Gaedigk
Andrea Gaedigk University of Missouri–Kansas City
Mont R. Juchau
Mont R. Juchau University of Washington
Steven A. Wrighton
Steven A. Wrighton Eli Lilly (United States)
Ronald N. Hines
Ronald N. Hines Yale University

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