World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
63
Citations
12601
World Ranking
8534
National Ranking
2446

Research.com Recognitions

  • 1994 - Prince Mahidol Award
  • 1973 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1973 - Member of the National Academy of Sciences
  • 1939 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William F. Trager is affiliated with the University of Washington in the United States. The data does not include specific details about their fields of study, subfields, or main topics of research. There is also no information about recent papers, co-authors, or frequent publication venues associated with this scientist.

The scientist has been recognized with several awards over their career. These awards include the Prince Mahidol Award received in 1994, fellowship at the John Simon Guggenheim Memorial Foundation granted in 1973, membership in the National Academy of Sciences awarded in 1973, and fellowship with the American Association for the Advancement of Science (AAAS) beginning in 1939.

Best Publications

  • Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

    A E Rettie;K R Korzekwa;K L Kunze;R F Lawrence

  • Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

    K E Thummel;D D Shen;T D Podoll;K L Kunze

  • Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

    Robert L. Haining;Ann P. Hunter;Maurice E. Veronese;William F. Trager

  • Cultivation of malarial parasites

    William Trager;James B. Jenson

  • Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6

    Weiqiao Chen;Luke L. Koenigs;Stella J. Thompson;Raimund M. Peter

  • Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

    Kent L. Kunze;William F. Trager

  • Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

    K E Thummel;D D Shen;T D Podoll;K L Kunze

  • The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

    Sidney D. Nelson;William F. Trager

  • Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies.

    D J Black;K L Kunze;L C Wienkers;B E Gidal

  • Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.

    Kent L. Kunze;Larry C. Wienkers;Kenneth E. Thummel;William F. Trager

  • The mechanism of the interaction between amiodarone and warfarin in humans

    Larry D Heimark;Larry Wienkers;Kent Kunze;Milo Gibaldi

  • Mechanism-Based Inactivation of Human Liver Cytochrome P450 2A6 by 8-Methoxypsoralen

    Luke L. Koenigs;Raimund M. Peter;Stella J. Thompson;Allan E. Rettie

  • Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.

    Larry C. Wienkers;Colleen J. Wurden;Elizabeth Storch;Kent L. Kunze

  • Mechanism-based inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins.

    Luke L. Koenigs;William F. Trager

  • Racemates versus enantiomers in drug development: dogmatism or pragmatism?

    Bernard Testa;William F. Trager

  • Intracellular phagotrophy by malaria parasites: an electron microscope study of Plasmodium lophurae*

    Maria A. Rudzinska;William Trager

  • Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9.

    Jeffrey P. Jones;Minxia He;William F. Trager;Allan E. Rettie

  • A Refined 3-Dimensional QSAR of Cytochrome P450 2C9: Computational Predictions of Drug Interactions

    Sreedhara Rao;Ron Aoyama;Michael Schrag;William F. Trager

  • Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans : In vitro and in vivo comparison and calculation of in vivo inhibition constants

    Agnès Tran;Elisabeth Rey;Gérard Pons;Marina Rousseau

  • Mechanism-based inactivation of P450 2A6 by furanocoumarins.

    Luke L. Koenigs;William F. Trager

  • Enzymatic Determinants of the Substrate Specificity of CYP2C9: Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding†

    Robert L. Haining;Jeffrey P. Jones;Kirk R. Henne;Michael B. Fisher

  • Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9.

    Luke L. Koenigs;Raimund M. Peter;Ann P. Hunter;Robert L. Haining

Frequent Co-Authors

Allan E. Rettie
Allan E. Rettie University of Washington
Kent L. Kunze
Kent L. Kunze University of Washington
Jeffrey P. Jones
Jeffrey P. Jones Washington State University
Sidney D. Nelson
Sidney D. Nelson University of Washington
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
James R. Gillette
James R. Gillette National Institutes of Health
Peter A. Kollman
Peter A. Kollman University of California, San Francisco
Evan D. Kharasch
Evan D. Kharasch Duke University
Steven A. Wrighton
Steven A. Wrighton Eli Lilly (United States)
Arnold L. Smith
Arnold L. Smith Center for Infectious Disease Research

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