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Evan D. Kharasch

Evan D. Kharasch

D-Index & Metrics

Medicine

D-Index
88
Citations
24297
World Ranking
13311
National Ranking
6772

Research.com Recognitions

  • 2013 - Member of the National Academy of Medicine (NAM)

Overview

Evan D. Kharasch is affiliated with Duke University in the United States and specializes in research largely within the field of medicine, focusing on anesthesiology, pharmacology, surgery, public health, and cardiovascular medicine.

The scientist's main research areas include:

  • Anesthesia and Pain Management
  • Pharmacogenetics and Drug Metabolism
  • Cardiac, Anesthesia and Surgical Outcomes
  • Anesthesia and Sedative Agents
  • Opioid Use Disorder Treatment
  • Pain Management and Opioid Use
  • Health and Medical Research Impacts

Kharasch has published extensively, contributing 114 works in medicine with a focus on 24 publications in anesthesiology and pain medicine, 20 in pharmacology, 20 in surgery, 18 in public health, environmental and occupational health, and 13 in cardiology and cardiovascular medicine.

Frequent publication venues include:

  • Anesthesiology (56 publications)
  • Anesthesia & Analgesia (5 publications)
  • British Journal of Anaesthesia (5 publications)
  • Clinical Pharmacology & Therapeutics (4 publications)
  • Drug Metabolism and Disposition (3 publications)

The following recent papers illustrate the thematic focus and years of activity:

  • "Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy", 2021, Clinical Pharmacology & Therapeutics
  • "Opioid-free Anesthesia: Time to Regain Our Balance", 2021, Anesthesiology
  • "Perioperative Gabapentinoids", 2020, Anesthesiology
  • "Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management", 2021, Anesthesiology
  • "Peer Review Matters: Research Quality and the Public Trust", 2020, Anesthesiology

Frequent coauthors engaged alongside Kharasch include:

  • Henry Ruth
  • Ralph Tovell
  • James E. Eckenhoff
  • Leroy D. Vandam
  • Arthur S. Keats

In 2013, Evan D. Kharasch was recognized as a Member of the National Academy of Medicine (NAM).

Best Publications

  • Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

    K R Crews;A Gaedigk;A Gaedigk;H M Dunnenberger;J S Leeder;J S Leeder

  • Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

    J K Hicks;K Sangkuhl;J J Swen;V L Ellingrod

  • Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants

    J. K. Hicks;J. J. Swen;C. F. Thorn;K. Sangkuhl

  • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

    Bojan Lalovic;Bojan Lalovic;Bojan Lalovic;Evan Kharasch;Evan Kharasch;Evan Kharasch;Christine Hoffer;Christine Hoffer;Christine Hoffer;Linda Risler;Linda Risler;Linda Risler

  • Psychedelic Effects of Ketamine in Healthy Volunteers Relationship to Steady-state Plasma Concentrations

    Andrew T. Bowdle;Allen D. Radant;Deborah S. Cowley;Evan D. Kharasch

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype

    K R Crews;A Gaedigk;H M Dunnenberger;T E Klein

  • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.

    Peter T. Manyike;Evan D. Kharasch;Thomas F. Kalhorn;John T. Slattery

  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane

    Evan D. Kharasch;Kenneth E. Thummel

  • Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D3

    Kenneth E. Thummel;Cynthia Brimer;Kazuto Yasuda;Jaideep Thottassery

  • Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.

    Rita B. Labroo;Mary F. Paine;Kenneth E. Thummel;Evan D. Kharasch

  • Nasal administration of opioids for pain management in adults.

    O Dale;R Hjortkjaer;E D Kharasch

  • Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

    Evan D. Kharasch;Christine Hoffer;Dale Whittington;Pamela Sheffels

  • Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol.

    Andra E. Ibrahim;Julie K. Taraday;Evan D. Kharasch

  • Gender differences in drug effects: implications for anesthesiologists

    H. Pleym;O. Spigset;E. D. Kharasch;O. Dale

  • Human Kidney Methoxyflurane and Sevoflurane Metabolism: Intrarenal Fluoride Production as a Possible Mechanism of Methoxyflurane Nephrotoxicity

    Evan D. Kharasch;Douglas C. Hankins;Kenneth E. Thummel

  • Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.

    Kristine R. Crews;Andrew A. Monte;Rachel Huddart;Kelly E. Caudle

  • Role of CYP2B6 in Stereoselective Human Methadone Metabolism

    Rheem A. Totah;Pamela Sheffels;Toni Roberts;Dale Whittington

  • CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease

    Maurice G. Emery;Jeannine M. Fisher;Jenny Y. Chien;Evan D. Kharasch

  • Assessment of Low-flow Sevoflurane and Isoflurane Effects on Renal Function Using Sensitive Markers of Tubular Toxicity

    Evan Kharasch;Edward Frink;Richard Zager;T. Bowdle

  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.

    Evan D. Kharasch;Christine Hoffer;Dale Whittington;Pam Sheffels

Frequent Co-Authors

Kenneth E. Thummel
Kenneth E. Thummel University of Washington
Srikanth Singamaneni
Srikanth Singamaneni Washington University in St. Louis
Dale Whittington
Dale Whittington University of North Carolina at Chapel Hill
Kent L. Kunze
Kent L. Kunze University of Washington
Jashvant D. Unadkat
Jashvant D. Unadkat University of Washington
Robert W. Gereau
Robert W. Gereau Washington University in St. Louis
Andrea Gaedigk
Andrea Gaedigk University of Missouri–Kansas City
Rajesh R. Naik
Rajesh R. Naik United States Air Force Research Laboratory
Allen D. Radant
Allen D. Radant University of Washington
Teri E. Klein
Teri E. Klein Stanford University

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