World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
85
Citations
23501
World Ranking
14715
National Ranking
1351

Overview

Amin Rostami-Hodjegan is affiliated with the University of Manchester in the United Kingdom. Their research spans multiple areas within medicine and pharmacology, focusing particularly on drug metabolism, pharmacogenetics, and clinical pharmacology.

The scientist's primary fields of study include:

  • Medicine
  • Pharmacology, Toxicology and Pharmaceutics

Within these areas, their subfields of expertise encompass:

  • Pharmacology
  • Oncology
  • Pediatrics, Perinatology and Child Health
  • Statistics and Probability
  • Molecular Biology

The main topics covered in their work are:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Statistical Methods in Clinical Trials
  • Pharmacological Effects and Toxicity Studies
  • Biosimilars and Bioanalytical Methods
  • Drug Solubility and Delivery Systems
  • Receptor Mechanisms and Signaling

Frequent co-authors collaborating with Amin Rostami-Hodjegan include:

  • Brahim Achour
  • Zubida M. Al-Majdoub
  • Jill Barber
  • Daniel Scotcher
  • Aleksandra Galetin

The scientist has contributed notably to publications in several prominent venues, including:

  • Clinical Pharmacology & Therapeutics
  • CPT Pharmacometrics & Systems Pharmacology
  • Drug Metabolism and Disposition
  • Drug Metabolism and Pharmacokinetics
  • The AAPS Journal

Some recent publications reflect the scope of their research interests and are as follows:

  • "Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy" (2020), published in The Annual Review of Pharmacology and Toxicology
  • "Physiological-based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20-years; in-depth analysis of applications, organizations, and platforms" (2020), published in Biopharmaceutics & Drug Disposition
  • "Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine" (2020), published in Drug Metabolism and Disposition
  • "Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters" (2020), published in Clinical Pharmacology & Therapeutics
  • "Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment" (2021), published in Molecular Pharmaceutics

Best Publications

  • Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children.

    Trevor N Johnson;Amin Rostami-Hodjegan;Amin Rostami-Hodjegan;Geoffrey T Tucker;Geoffrey T Tucker

  • Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

    Amin Rostami-Hodjegan;Geoffrey T. Tucker

  • The Simcyp® population-based ADME simulator

    Masoud Jamei;Steve Marciniak;Kairui Feng;Adrian Barnett

  • Population-Based Mechanistic Prediction of Oral Drug Absorption

    Masoud Jamei;David Turner;Jiansong Yang;Sibylle Neuhoff

  • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

    Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  • Prediction of intestinal first-pass drug metabolism.

    Jiansong Yang;Masoud Jamei;Karen Rowland Yeo;Geoffrey T. Tucker

  • Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: A database for parameters required in physiologically based pharmacokinetic modelling

    Khaled Abduljalil;Penny Furness;Trevor N. Johnson;Amin Rostami-Hodjegan;Amin Rostami-Hodjegan

  • Modified-Release Hydrocortisone to Provide Circadian Cortisol Profiles

    Miguel Debono;Cyrus Ghobadi;Amin Rostami-Hodjegan;Hiep Huatan

  • A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

    Masoud Jamei;Gemma L. Dickinson;Amin Rostami-Hodjegan;Amin Rostami-Hodjegan

  • Changes in liver volume from birth to adulthood: A meta‐analysis

    Trevor N. Johnson;Geoffrey T. Tucker;Geoffrey T. Tucker;M. Stuart Tanner;Amin Rostami‐Hodjegan;Amin Rostami‐Hodjegan

  • Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.

    A Rostami-Hodjegan;A Rostami-Hodjegan

  • PBPK models for the prediction of in vivo performance of oral dosage forms

    Edmund S. Kostewicz;Leon Aarons;Martin Bergstrand;Michael B. Bolger

  • Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency.

    Peak M. Mah;Richard C. Jenkins;Amin Rostami-Hodjegan;John Newell-Price

  • ‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions

    Amin Rostami-Hodjegan;Amin Rostami-Hodjegan;Geoff Tucker

  • Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.

    Jiansong Yang;Mingxiang Liao;Magang Shou;Masoud Jamei

  • Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data.

    Nikolaos Tsamandouras;Amin Rostami-Hodjegan;Amin Rostami-Hodjegan;Leon Aarons

  • Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

    Karen Rowland Yeo;Masoud Jamei;Jiansong Yang;Geoffrey T. Tucker;Geoffrey T. Tucker

  • Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability

    E. M. Howgate;K. Rowland Yeo;N. J. Proctor;G. T. Tucker

  • Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

    N J Proctor;G T Tucker;A Rostami-Hodjegan

  • Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model

    A. S. Darwich;S. Neuhoff;M. Jamei;A. Rostami-Hodjegan

Frequent Co-Authors

Richard J. Ross
Richard J. Ross University of Sheffield
Hans Lennernäs
Hans Lennernäs Uppsala University
Jashvant D. Unadkat
Jashvant D. Unadkat University of Washington
Meindert Danhof
Meindert Danhof Leiden University
William J. Ledger
William J. Ledger University of New South Wales
Lawrence J. Lesko
Lawrence J. Lesko University of Florida
Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
J. Brian Houston
J. Brian Houston University of Manchester
Simon Heller
Simon Heller University of Sheffield
Per Artursson
Per Artursson Uppsala University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in medicine, there are numerous online degrees and career options beyond traditional MD programs. Many roles in healthcare now offer flexible, accredited online training that can help you enter the workforce or advance your career.

Those aiming for leadership roles in nursing may consider pursuing one of the cheapest online dnp programs, which provide a pathway to the highest levels of nursing practice with lower tuition costs. Similarly, if you’re interested in the pharmaceutical field, it’s important to research online pharmacy school cost to find affordable and reputable programs.

Not all medical careers require direct patient care. Those interested in healthcare technology can look into health information technology programs online, which focus on managing crucial patient data and health systems. If administrative work appeals to you, consider exploring the cheapest medical coding certification online to quickly gain the credentials needed to join the growing field of medical billing and coding.

Exploring these online pathways can expand your career opportunities and help you find the best fit in the vast world of healthcare.

Best Scientists Citing Amin Rostami-Hodjegan

Trending Scientists