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Patrick Augustijns

Patrick Augustijns

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Chemistry
Belgium
2025

D-Index & Metrics

Chemistry

D-Index
86
Citations
22863
World Ranking
2593
National Ranking
31

Research.com Recognitions

  • 2025 - Research.com Chemistry in Belgium Leader Award
  • 2022 - Research.com Chemistry in Belgium Leader Award

Overview

Patrick Augustijns is affiliated with KU Leuven in Belgium, contributing extensively to the fields of Medicine and Pharmacology, Toxicology, and Pharmaceutics. Their research is focused on Pharmaceutical Science, Gastroenterology, Surgery, Infectious Diseases, and Oncology. Within these areas, their work frequently addresses topics such as Drug Solubility and Delivery Systems, Gastrointestinal Motility and Disorders, Drug Transport and Resistance Mechanisms, Gastroesophageal Reflux and Treatments, Analytical Chemistry and Chromatography, Helicobacter pylori-related gastroenterology studies, and Analytical Methods in Pharmaceuticals.

Patrick Augustijns has collaborated with several frequent co-authors, which include:

  • Joachim Brouwers
  • Tim Vanuytsel
  • Raf Mols
  • Jan Tack
  • Christophe Matthys

The scientist's research has been published in multiple peer-reviewed venues, with notable frequency in:

  • International Journal of Pharmaceutics
  • Pharmaceutics
  • European Journal of Pharmaceutical Sciences
  • European Journal of Pharmaceutics and Biopharmaceutics
  • Molecular Pharmaceutics

Some recent significant papers authored include:

  • Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review, 2021, European Journal of Pharmaceutical Sciences
  • Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity, 2020, Proceedings of the National Academy of Sciences
  • Local immune response to food antigens drives meal-induced abdominal pain, 2021, Nature
  • Impact of gastrointestinal physiology on drug absorption in special populations--An UNGAP review, 2020, European Journal of Pharmaceutical Sciences
  • The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model, 2021, EBioMedicine

Best Publications

  • Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?

    Joachim Brouwers;Marcus E Brewster;Patrick Augustijns

  • Top-Down Production of Drug Nanocrystals - Nanosuspension Stabilization, Miniaturization and Transformation Into Solid Products

    Bernard Van Eerdenbrugh;Guy Van den Mooter;Patrick Augustijns

  • In vitro models for the prediction of in vivo performance of oral dosage forms

    Edmund S. Kostewicz;Bertil Abrahamsson;Marcus Brewster;Joachim Brouwers

  • Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

    Mira M. Wouters;Dafne Balemans;Sander Van Wanrooy;James Dooley

  • Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Ben J. Boyd;Christel A.S. Bergström;Zahari Vinarov;Martin Kuentz

  • In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

    Erik Sjögren;Bertil Abrahamsson;Patrick Augustijns;Dieter Becker

  • Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.

    Festo Damian;Norbert Blaton;Lieve Naesens;Jan Balzarini

  • Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

    Rose Hayeshi;Constanze Hilgendorf;Per Artursson;Patrick Augustijns

  • The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

    Mirko Koziolek;Stefano Alcaro;Patrick Augustijns;Abdul W. Basit

  • Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen.

    Randy Mellaerts;Jasper A. G. Jammaer;Michiel Van Speybroeck;Hong Chen

  • Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

    Michiel Van Speybroeck;Valéry Barillaro;Thao Do Thi;Randy Mellaerts

  • A screening study of surface stabilization during the production of drug nanocrystals

    Bernard Van Eerdenbrugh;Jan Vermant;Johan A. Martens;Ludo Froyen

  • Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

    Jan Bevernage;Joachim Brouwers;Marcus E. Brewster;Patrick Augustijns

  • Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

    Randy Mellaerts;Raf Mols;Jasper A.G. Jammaer;Caroline A. Aerts

  • Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity

    Suzanne J. F. Kaptein;Sofie Jacobs;Lana Langendries;Laura Seldeslachts

  • Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.

    Bram Slütter;Suzanne Bal;Chantal Keijzer;Roel Mallants

  • Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions

    Danny Riethorst;Raf Mols;Guus Duchateau;Jan Tack

  • Drying of crystalline drug nanosuspensions : The importance of surface hydrophobicity on dissolution behavior upon redispersion

    Bernard Van Eerdenbrugh;Ludo Froyen;Jan Van Humbeeck;Johan A. Martens

  • Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials

    Randy Mellaerts;Caroline A. Aerts;Jan Van Humbeeck;Patrick Augustijns

  • Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica.

    Michiel Van Speybroeck;Randy Mellaerts;Raf Mols;Thao Do Thi

  • Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.

    Mariangeles Perez de la Cruz Moreno;Marianne Oth;Sven Deferme;Frank Lammert

  • Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport

    P.F. Augustijns;T.P. Bradshaw;L.S.L. Gan;R.W. Hendren

  • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

    L.-S. L. Gan;M. A. Moseley;B. Khosla;P. F. Augustijns

  • A Review of Drug Solubility in Human Intestinal Fluids: Implications for the Prediction of Oral Absorption

    Patrick Augustijns;Benjamin Wuyts;Bart Hens;Pieter Annaert

Frequent Co-Authors

Jan Tack
Jan Tack KU Leuven
Jan Vermant
Jan Vermant ETH Zurich
Marcus E. Brewster
Marcus E. Brewster Johnson & Johnson (United States)
Ludo Froyen
Ludo Froyen KU Leuven
Dhiren R. Thakker
Dhiren R. Thakker University of North Carolina at Chapel Hill
Anette Müllertz
Anette Müllertz University of Copenhagen

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