Hans Lennernäs

Overview

Best Publications

• A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

  Gordon L. Amidon;Hans Lennernäs;Vinod P. Shah;John R. Crison

  7178
  Citations

• Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences.

  Hans Lennernäs;Gunnar Fager

  743
  Citations

• Human intestinal permeability.

  Hans Lennernäs

  673
  Citations

• Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach.

  Susanne Winiwarter;Nicholas M. Bonham;Fredrik Ax;Anders Hallberg

  615
  Citations

• Comparison Between Permeability Coefficients in Rat and Human Jejunum

  Urban Fagerholm;Monica Johansson;Hans Lennernäs

  601
  Citations

• Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women

  Anders Lindahl;Anna-Lena Ungell;Lars Knutson;Hans Lennernäs

  598
  Citations

• Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

  Xianhua Cao;Seth T. Gibbs;Lanyan Fang;Heather A. Miller

  448
  Citations

• Chitosans as absorption enhancers of poorly absorbable drugs: 3: Influence of mucus on absorption enhancement

  Nicolaas G.M. Schipper;Kjell M. Vårum;Patric Stenberg;Göran Ocklind

  425
  Citations

• Membrane transport of drugs in different regions of the intestinal tract of the rat

  A.-L. Ungell;S. Nylander;S. Bergstrand;Å. Sjöberg

  367
  Citations

• The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids.

  Eva M. Persson;Ann-Sofie Gustafsson;Anders S. Carlsson;Ralf G. Nilsson

  361
  Citations

• Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo

  H. Lennernäs;K. Palm;U. Fagerholm;P. Artursson

  353
  Citations

• Intestinal permeability and its relevance for absorption and elimination.

  Lennernäs H

  352
  Citations

• Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation.

  G. Johannsson;A. G. Nilsson;R. Bergthorsdottir;P. Burman

  350
  Citations

• In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

  Erik Sjögren;Bertil Abrahamsson;Patrick Augustijns;Dieter Becker

  339
  Citations

• Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man.

  Hans Lennernäs;Örjan Ahrenstedt;Roger Hällgren;Lars Knutson

  320
  Citations

• Optimizing levodopa pharmacokinetics: intestinal infusion versus oral sustained-release tablets.

  Dag Nyholm;Håkan Askmark;Cecilia Gomes-Trolin;Tina Knutson

  306
  Citations

• Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.

  Niclas Petri;Christer Tannergren;Birgit Holst;Birgit Holst;Fred A. Mellon

  302
  Citations

• Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models

  Hans Lennernäs

  284
  Citations

• The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

  Hans Lennernäs;Bertil Abrahamsson

  282
  Citations

• Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability

  Han van de Waterbeemd;Hans Lennernäs;Per Artursson

  275
  Citations