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Medicine

D-Index
108
Citations
41639
World Ranking
6017
National Ranking
3218

Overview

Barry J. Hoffer is affiliated with Case Western Reserve University in the United States. Their research spans several interconnected fields including Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with significant contributions distributed primarily across Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Physiology, and Immunology.

The principal topics covered in their work include Neuroinflammation and Neurodegeneration Mechanisms, Alzheimer's disease research and treatments, Parkinson's Disease Mechanisms and Treatments, Histone Deacetylase Inhibitors Research, Traumatic Brain Injury and Neurovascular Disturbances, Neurological disorders and treatments, and Protein Degradation and Inhibitors.

Barry J. Hoffer's recent publications demonstrate involvement in investigations around neuroinflammation, neuroprotection, and molecular mechanisms underlying brain function. Notable recent papers include:

  • Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis (2022, Alzheimer's & Dementia)
  • CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury (2021, Redox Biology)
  • CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation (2021, Molecular Psychiatry)
  • Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury (2020, eLife)
  • Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury (2020, Frontiers in Cell and Developmental Biology)

Frequent publication venues for their work include:

  • Alzheimer's & Dementia
  • Journal of Biomedical Science
  • GeroScience
  • Journal of Parkinson's Disease
  • eLife

Collaboration has been an important aspect of their career, with frequent coauthors including Nigel H. Greig, David Tweedie, Shih-Chang Hsueh, Daniela Lecca, and Dong Seok Kim.

Best Publications

  • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

    A. Tomac;E. Lindqvist;L.-F. H. Lin;S. O. Ögren

  • Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system

    Mark J. Perlow;William J. Freed;Barry J. Hoffer;Ake Seiger

  • Defects in enteric innervation and kidney development in mice lacking GDNF

    José G. Pichel;Liya Shen;Hui Z. Sheng;Ann-Charlotte Granholm

  • Dopamine neuron agenesis in Nurr1-deficient mice.

    Rolf H. Zetterström;Ludmila Solomin;Ludmila Solomin;Ludmila Solomin;Lottie Jansson;Lottie Jansson;Lottie Jansson;Barry J. Hoffer;Barry J. Hoffer;Barry J. Hoffer

  • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

    Yazhou Li;Tracy Ann Perry;Mark S. Kindy;Brandon K. Harvey

  • Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up

    Olle Lindvall;Stig Rehncrona;Patrik Brundin;Björn Gustavii

  • Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behaviour

    William J. Freed;John M. Morihisa;Eleanor Spoor;Barry J. Hoffer

  • Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats.

    John L. Hudson;Craig G. van Horne;Ingrid Strömberg;Scot Brock

  • Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition.

    B. J. Hoffer;G. R. Siggins;A. P. Oliver;F. E. Bloom

  • Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis

    B.J. Hoffer;G.R. Siggins;F.E. Bloom

  • Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: long-term behavioral, biochemical, and histochemical studies.

    William J. Freed;William J. Freed;William J. Freed;Mark J. Perlow;Mark J. Perlow;Mark J. Perlow;Farouk Karoum;Farouk Karoum;Farouk Karoum;Ake Seiger;Ake Seiger;Ake Seiger

  • Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. I. Localization of the fibers and their synapses

    F.E. Bloom;B.J. Hoffer;G.R. Siggins

  • The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells.

    D.J. Woodward;D.J. Woodward;B.J. Hoffer;B.J. Hoffer;G.R. Siggins;G.R. Siggins;F.E. Bloom;F.E. Bloom

  • Glial Cell Line-Derived Neurotrophic Factor Is Expressed in the Developing but Not Adult Striatum and Stimulates Developing Dopamine Neurons in Vivo

    Ingrid Strömberg;Lars Björklund;Maria Johansson;Andreas Tomac

  • Blood-brain barrier penetration and in vivo activity of an NGF conjugate

    Phillip M. Friden;Lee R. Walus;Patricia Watson;Susan R. Doctrow

  • Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs

    Johan Widenfalk;Christopher Nosrat;Andreas Tomac;Andreas Tomac;Heiner Westphal

  • Glial Cell Line-Derived Neurotrophic Factor Supports Survival of Injured Midbrain Dopaminergic Neurons

    Kathryn E. Bowenkamp;Alexander F. Hoffman;Greg A. Gerhardt;Michael A. Henry

  • Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.

    Andreas Tomac;Johan Widenfalk;Leu-Fen H. Lin;Tadahiko Kohno

  • Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen.

    Olle Lindvall;Erik‐Olof Backlund;Lars Farde;Göran Sedvall

  • Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

    Christopher A. Nosrat;Andreas Tomac;Eva Lindqvist;Sven Lindskog

Frequent Co-Authors

Floyd E. Bloom
Floyd E. Bloom Scripps Research Institute
George R. Siggins
George R. Siggins Scripps Research Institute
Lars Olson
Lars Olson Karolinska Institute
Robert Freedman
Robert Freedman University of Colorado Anschutz Medical Campus
Yun Wang
Yun Wang Peking University
Greg A. Gerhardt
Greg A. Gerhardt University of Kentucky
Åke Seiger
Åke Seiger Karolinska Institute
Ingrid Strömberg
Ingrid Strömberg Umeå University
Paula C. Bickford
Paula C. Bickford University of South Florida
Richard Jed Wyatt
Richard Jed Wyatt St. Elizabeths Hospital

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