World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
14829
World Ranking
15416
National Ranking
372

Overview

Dik C. van Gent is affiliated with Erasmus University Rotterdam in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, Pulmonary and Respiratory Medicine, and Otorhinolaryngology.

The scientist's work covers multiple core topics including DNA Repair Mechanisms, Head and Neck Cancer Studies, PARP inhibition in cancer therapy, Advanced Radiotherapy Techniques, Radiation Therapy and Dosimetry, BRCA gene mutations in cancer, and CRISPR and Genetic Engineering.

Key recent papers authored or co-authored by Dik C. van Gent include:

  • Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy, 2020, European Journal of Nuclear Medicine and Molecular Imaging
  • Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells, 2020, International Journal of Molecular Sciences
  • Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity, 2022, Proceedings of the National Academy of Sciences
  • Homologous Recombination Deficiency Testing for BRCA-Like Tumors: The Road to Clinical Validation, 2021, Cancers
  • Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests, 2022, Oncogene

Frequent collaborators include Nicole S. Verkaik, Roland Kanaar, Steven Petit, Marta Capala, and Agnes Jager.

Dik C. van Gent has published extensively in several academic venues, notably:

  • Cancers
  • International Journal of Molecular Sciences
  • Radiotherapy and Oncology
  • Cancer Research
  • npj Breast Cancer

The scientist's research integrates experimental and clinical aspects of cancer biology, focusing in particular on mechanisms of DNA repair and therapeutic approaches that involve radiation and molecular targeting. Their work often explores the interplay of genetic mutations, especially related to BRCA genes, and the impact of advanced radiotherapy techniques on cancer treatment outcomes.

Best Publications

  • Chromosomal stability and the DNA double-stranded break connection.

    Dik C. van Gent;Jan H. J. Hoeijmakers;Roland Kanaar

  • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

    J.Fraser McBlane;Dik C. van Gent;Dale A. Ramsden;Charles Romeo

  • DNA double-strand break repair: from mechanistic understanding to cancer treatment.

    Thomas Helleday;Justin Lo;Dik C. van Gent;Bevin P. Engelward

  • Molecular mechanisms of DNA double-strand break repair

    Roland Kanaar;Jan H.J Hoeijmakers;Dik C van Gent

  • Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

    Martijn de Jager;John van Noort;Dik C. van Gent;Cees Dekker

  • REV7 counteracts DNA double-strand break resection and affects PARP inhibition

    Guotai Xu;J. Ross Chapman;Inger Brandsma;Jingsong Yuan

  • Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

    Naoya Uematsu;Eric Weterings;Ken Ichi Yano;Keiko Morotomi-Yano

  • Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

    Pierre-Olivier Mari;Bogdan I. Florea;Stephan P. Persengiev;Nicole S. Verkaik

  • Initiation of V(D)J recombination in a cell-free system

    Dik C van Gent;J Fraser McBlane;Dale A Ramsden;Moshe J Sadofsky

  • The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

    Dik C van Gent;Dale A Ramsden;Martin Gellert

  • Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

    Hiroshi Tauchi;Junya Kobayashi;Ken ichi Morishima;Dik C. Van Gent

  • Pathway choice in DNA double strand break repair: observations of a balancing act

    Inger Brandsma;Dik C van Gent

  • Stimulation of V(D)J cleavage by high mobility group proteins

    Dik C. van Gent;Kevin Hiom;Tanya T. Paull;Martin Gellert

  • The mechanism of non-homologous end-joining: a synopsis of synapsis.

    Eric Weterings;Dik C. van Gent

  • A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining

    Mirjam Van Der Burg;Hanna IJspeert;Nicole S. Verkaik;Tuba Turul

  • MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

    Joris Pothof;Nicole S Verkaik;Wilfred van IJcken;Erik A C Wiemer

  • Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.

    Nicole S. Verkaik;Rebecca E. E. Esveldt-van Lange;Diana van Heemst;Hennie T. Brüggenwirth

  • A new type of radiosensitive T–B–NK+ severe combined immunodeficiency caused by a LIG4 mutation

    Mirjam van der Burg;Lieneke R. van Veelen;Nicole S. Verkaik;Wouter W. Wiegant

  • Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment

    Kishan A.T. Naipal;Nicole S. Verkaik;Najim Ameziane;Carolien H.M. van Deurzen

  • The role of DNA dependent protein kinase in synapsis of DNA ends

    Eric Weterings;Nicole S. Verkaik;Hennie T. Brüggenwirth;Jan H. J. Hoeijmakers

Frequent Co-Authors

Roland Kanaar
Roland Kanaar Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Mirjam van der Burg
Mirjam van der Burg Erasmus University Rotterdam
Jacques J.M. van Dongen
Jacques J.M. van Dongen Leiden University Medical Center
Jos Jonkers
Jos Jonkers Antoni van Leeuwenhoek Hospital
Marion de Jong
Marion de Jong Erasmus University Rotterdam
Sven Rottenberg
Sven Rottenberg University of Bern
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Claire Wyman
Claire Wyman Erasmus MC

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can open doors to a range of dynamic careers in health, science, and research. Many students choose to broaden their expertise through online programs that offer flexibility and diverse specialization options.

For those interested in health, fitness, or preventative medicine, consider an exercise science and nutrition degree online. This pathway helps students explore human physiology, nutrition, and wellness strategies relevant to personal training, healthcare, and even sports management.

If your interests align more with human movement and rehabilitation, enrolling in the best online kinesiology degree can provide a robust foundation for careers in therapy, sports science, or research.

Advanced practitioners looking to specialize may benefit from the shortest post master's pmhnp online programs or a flexible 12-month fnp program online. These programs allow professionals to quickly gain specialized credentials in mental health, family practice, and advanced nursing.

Streamlined online pathways empower students and professionals to upskill efficiently, adapt to industry demands, and pursue fulfilling careers related to Biology and Biochemistry.

Best Scientists Citing Dik C. van Gent

Trending Scientists

Recently Published Articles