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Molecular Biology
Netherlands
2023

D-Index & Metrics

Molecular Biology

D-Index
91
Citations
27781
World Ranking
724
National Ranking
19

Research.com Recognitions

  • 2023 - Research.com Molecular Biology in Netherlands Leader Award
  • 2013 - Royal Netherlands Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Roland Kanaar is affiliated with Erasmus University Rotterdam in the Netherlands and is active in the fields of Biochemistry, Genetics, and Molecular Biology, with additional work intersecting Medicine. Their research output covers multiple subfields, notably Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Biomedical Engineering, and Infectious Diseases.

Their primary research topics include DNA Repair Mechanisms, CRISPR and Genetic Engineering, and PARP inhibition in cancer therapy, alongside studies on fungal and yeast genetics, aortic aneurysm repair treatments, connective tissue disorders, and genetics related to aging and longevity in model organisms.

Among the recent papers authored or co-authored by Roland Kanaar are:

  • "Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants" (2021), Journal of Molecular Biology
  • "DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage" (2020), Cancers
  • "Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells" (2020), International Journal of Molecular Sciences
  • "Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability" (2023), Nature Cell Biology
  • "DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation" (2021), Frontiers in Genetics

Frequent collaborators include:

  • Jeroen Essers
  • Dik C. van Gent
  • Alex N. Zelensky
  • Claire Wyman
  • Maarten W. Paul

Roland Kanaar's work has been published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancers, Zenodo (CERN European Organization for Nuclear Research), Nucleic Acids Research, and DNA Repair.

They have received recognition including membership in the Royal Netherlands Academy of Arts and Sciences (2013) and as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Chromosomal stability and the DNA double-stranded break connection.

    Dik C. van Gent;Jan H. J. Hoeijmakers;Roland Kanaar

  • DNA Double-Strand Break Repair: All's Well that Ends Well

    Claire Wyman;Roland Kanaar

  • Repair of DNA interstrand cross-links.

    Mies L.G Dronkert;Roland Kanaar

  • Molecular mechanisms of DNA double-strand break repair

    Roland Kanaar;Jan H.J Hoeijmakers;Dik C van Gent

  • Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

    Ate Loonstra;Marc Vooijs;H. Berna Beverloo;Bushra Al Allak

  • Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

    Martijn de Jager;John van Noort;Dik C. van Gent;Cees Dekker

  • Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

    Jeroen Essers;Rudolf W Hendriks;Sigrid M.A Swagemakers;Christine Troelstra

  • The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

    Laura J. Niedernhofer;Hanny Odijk;Magda Budzowska;Ellen van Drunen

  • Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains

    Jacob A. Aten;Jan Stap;Przemek M. Krawczyk;Carel H. van Oven

  • Nuclear dynamics of PCNA in DNA replication and repair.

    Jeroen Essers;Arjan F. Theil;Céline Baldeyron;Wiggert A. van Cappellen

  • ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor

    Elisabetta Citterio;Vincent Van Den Boom;Gavin Schnitzler;Roland Kanaar

  • The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.

    Katsuhiro Hanada;Katsuhiro Hanada;Magda Budzowska;Sally L Davies;Ellen van Drunen

  • Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

    Lilach Moyal;Yaniv Lerenthal;Mali Gana-Weisz;Gilad Mass

  • Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

    Ivan M. Muñoz;Karolina Hain;Anne-Cécile Déclais;Mary Gardiner

  • Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

    Noemi A. Zambetti;Zhen Ping;Si Chen;Keane J.G. Kenswil

  • Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

    Maria Kraakman-van der Zwet;Wilhelmina J. I. Overkamp;Rebecca E. E. van Lange;Jeroen Essers

  • Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

    Przemek M. Krawczyk;Berina Eppink;Jeroen Essers;Jan Stap

  • Homologous and non-homologous recombination differentially affect DNA damage repair in mice

    Jeroen Essers;Harry van Steeg;Jan de Wit;Sigrid M.A. Swagemakers

  • The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

    Katsuhiro Hanada;Magdalena Budzowska;Mauro Modesti;Alex Maas

  • The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

    Minoru Takata;Masao S. Sasaki;Eiichiro Sonoda;Toru Fukushima

Frequent Co-Authors

Jeroen Essers
Jeroen Essers Erasmus University Rotterdam
Claire Wyman
Claire Wyman Erasmus MC
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Dik C. van Gent
Dik C. van Gent Erasmus University Rotterdam
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Cees Dekker
Cees Dekker Delft University of Technology
Laura J. Niedernhofer
Laura J. Niedernhofer University of Minnesota
Jan de Boer
Jan de Boer Antoni van Leeuwenhoek Hospital
Adriaan B. Houtsmuller
Adriaan B. Houtsmuller Erasmus University Rotterdam

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