2013 - Royal Netherlands Academy of Arts and Sciences
Member of the European Molecular Biology Organization (EMBO)
Roland Kanaar spends much of his time researching DNA repair, Molecular biology, Homologous recombination, DNA damage and Genetics. His DNA repair study integrates concerns from other disciplines, such as Replication protein A and Cell biology. His study in Replication protein A is interdisciplinary in nature, drawing from both DNA replication and DNA mismatch repair.
Roland Kanaar combines subjects such as DNA repair protein XRCC4, Sister chromatid exchange, HMG-box, Endonuclease and DNA ligase with his study of Molecular biology. His Homologous recombination research integrates issues from Gene targeting and MUS81. His research in DNA damage intersects with topics in Mutation and Gene.
Roland Kanaar mainly focuses on DNA repair, Homologous recombination, DNA, Molecular biology and DNA damage. His DNA repair research is multidisciplinary, incorporating perspectives in Replication protein A and Cell biology. His Homologous recombination research incorporates themes from Genetic recombination and Cancer research.
His work deals with themes such as Homologous chromosome, Recombination, Ionizing radiation, Biophysics and Chromosome, which intersect with DNA. His research integrates issues of Sister chromatid exchange, Mutant, Chromatid, Sister chromatids and MUS81 in his study of Molecular biology. His work is dedicated to discovering how DNA damage, G2-M DNA damage checkpoint are connected with CHEK1 and other disciplines.
His scientific interests lie mostly in Cancer research, Homologous recombination, RAD51, Ex vivo and DNA repair. His Cancer research study integrates concerns from other disciplines, such as DNA damage, Cisplatin, Cancer cell, Immunology and Radiation therapy. He works mostly in the field of Homologous recombination, limiting it down to concerns involving Genetic recombination and, occasionally, Homology directed repair, Molecular biology, DNA repair protein XRCC4, Replication protein A and DNA sequencing.
His studies in RAD51 integrate themes in fields like Breast cancer and Chromosome instability. His work in DNA repair covers topics such as Cell culture which are related to areas like DNA replication factor CDT1. His DNA research incorporates elements of Computational biology and Cell biology.
His main research concerns Internal medicine, Genetics, Homologous recombination, Cancer research and Hyperthermia. The Glycogen research he does as part of his general Internal medicine study is frequently linked to other disciplines of science, such as Vascular smooth muscle, therefore creating a link between diverse domains of science. He is investigating Homologous recombination as part of his Gene and DNA and Homologous recombination study.
His work carried out in the field of Gene brings together such families of science as Ex vivo and Breast cancer. In his study, which falls under the umbrella issue of Cancer research, Genotoxic Stress, Hematopoietic stem cell and DNA damage is strongly linked to Immunology. His Hyperthermia research focuses on subjects like Oncology, which are linked to Surgery, Chemotherapy and Targeted therapy.
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Chromosomal stability and the DNA double-stranded break connection.
Dik C. van Gent;Jan H. J. Hoeijmakers;Roland Kanaar.
Nature Reviews Genetics (2001)
DNA Double-Strand Break Repair: All's Well that Ends Well
Claire Wyman;Roland Kanaar.
Annual Review of Genetics (2006)
Repair of DNA interstrand cross-links.
Mies L.G Dronkert;Roland Kanaar.
Mutation Research-dna Repair (2001)
Molecular mechanisms of DNA double-strand break repair
Roland Kanaar;Jan H.J Hoeijmakers;Dik C van Gent.
Trends in Cell Biology (1998)
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
Ate Loonstra;Marc Vooijs;H. Berna Beverloo;Bushra Al Allak.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination
Jeroen Essers;Rudolf W Hendriks;Sigrid M.A Swagemakers;Christine Troelstra.
Cell (1997)
Human Rad50/Mre11 is a flexible complex that can tether DNA ends.
Martijn de Jager;John van Noort;Dik C. van Gent;Cees Dekker.
Molecular Cell (2001)
The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks
Laura J. Niedernhofer;Hanny Odijk;Magda Budzowska;Ellen van Drunen.
Molecular and Cellular Biology (2004)
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.
Jacob A. Aten;Jan Stap;Przemek M. Krawczyk;Carel H. van Oven.
Science (2004)
ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor
Elisabetta Citterio;Vincent Van Den Boom;Gavin Schnitzler;Roland Kanaar.
Molecular and Cellular Biology (2000)
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