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Molecular Biology
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Molecular Biology

D-Index
146
Citations
71677
World Ranking
98
National Ranking
62

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award

Overview

John A. Tainer is affiliated with The University of Texas MD Anderson Cancer Center in the United States. The research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology with a focus on Molecular Biology, Oncology, Cancer Research, Genetics, and Immunology. Their work explores several key topics, including DNA Repair Mechanisms, PARP inhibition in cancer therapy, CRISPR and Genetic Engineering, RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, and Enzyme Structure and Function.

Frequent co-authors collaborating with John A. Tainer include:

  • Albino Bacolla
  • Chi-Lin Tsai
  • Susan E. Tsutakawa
  • Aleem Syed
  • Zamal Ahmed

The scientist's publications are often found in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Progress in Biophysics and Molecular Biology
  • Journal of Biological Chemistry

Recent papers authored or co-authored by John A. Tainer include:

  • "PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis," 2020, Nature Cell Biology
  • "A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors," 2021, Nature Cancer
  • "Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1," 2022, Cancer Discovery
  • "Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development," 2020, Molecular and Cellular Biology
  • "Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations," 2020, Proceedings of the National Academy of Sciences

Best Publications

  • Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

    Han Xiang Deng;Afif Hentati;John A. Tainer;Zafar Iqbal

  • X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.

    Christopher D. Putnam;Michal Hammel;Greg L. Hura;John A. Tainer

  • Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase.

    John A. Tainer;Elizabeth D. Getzoff;Karl M. Beem;Jane S. Richardson

  • Structure and mechanism of copper, zinc superoxide dismutase

    John A. Tainer;Elizabeth D. Getzoff;Elizabeth D. Getzoff;Jane S. Richardson;David C. Richardson

  • Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.

    Karl Peter Hopfner;Annette Karcher;David S. Shin;Lisa Craig

  • MODBASE, a database of annotated comparative protein structure models, and associated resources

    Ursula Pieper;Narayanan Eswar;Ben M. Webb;David Eramian;David Eramian

  • Type IV pilus structure and bacterial pathogenicity

    Lisa Craig;Michael E. Pique;John A. Tainer

  • DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

    Clifford D. Mol;Tadahide Izumi;Sankar Mitra;John A. Tainer

  • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.

    Brian R. Crane;Brian R. Crane;Andrew S. Arvai;Dipak K. Ghosh;Chaoqun Wu

  • Accurate assessment of mass, models and resolution by small-angle scattering

    Robert P. Rambo;John A. Tainer

  • Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

    Greg L. Hura;Angeli L. Menon;Michal Hammel;Robert P. Rambo

  • Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

    Elizabeth D. Getzoff;John A. Tainer;Paul K. Weiner;Peter A. Kollman

  • The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

    Karl Peter Hopfner;Lisa Craig;Gabriel Moncalian;Robert A. Zinkel

  • Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

    Robert P. Rambo;John A. Tainer

  • PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

    Junwei Hou;Rongce Zhao;Rongce Zhao;Rongce Zhao;Weiya Xia;Chiung Wen Chang

  • Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

    James F. Collawn;Martin Stangel;Leslie A. Kuhn;Victor Esekogwu

  • A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.

    Geir Slupphaug;Clifford D. Mol;Bodil Kavli;Andrew S. Arvai

  • Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

    Karl Peter Hopfner;Annette Karcher;Lisa Craig;Tammy T. Woo

  • Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.

    Christopher D Putnam;Andrew S Arvai;Yves Bourne;John A Tainer

  • DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.

    Atsushi Shibata;Atsushi Shibata;Davide Moiani;Davide Moiani;Andrew S. Arvai;Andrew S. Arvai;Jefferson Perry;Jefferson Perry;Jefferson Perry

Frequent Co-Authors

Elizabeth D. Getzoff
Elizabeth D. Getzoff Scripps Research Institute
Andrew S. Arvai
Andrew S. Arvai Scripps Research Institute
Susan P. Lees-Miller
Susan P. Lees-Miller University of Calgary
Christopher D. Putnam
Christopher D. Putnam University of California, San Diego
Diane E. Cabelli
Diane E. Cabelli Brookhaven National Laboratory
Tom Ellenberger
Tom Ellenberger Washington University in St. Louis
Brian R. Crane
Brian R. Crane Cornell University
David N. Silverman
David N. Silverman University of Florida
Hans E. Krokan
Hans E. Krokan Norwegian University of Science and Technology
Geir Slupphaug
Geir Slupphaug Norwegian University of Science and Technology

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