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Chemistry

D-Index
67
Citations
15670
World Ranking
6913
National Ranking
2064

Overview

Hung-wen Liu is affiliated with The University of Texas at Austin in the United States and has a research portfolio concentrated in biochemistry, genetics, molecular biology, and chemistry. Their work reflects an interdisciplinary approach, combining detailed molecular studies with broader chemical investigations.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Chemistry

Within these broader areas, Liu's research spans multiple subfields such as:

  • Molecular Biology
  • Renewable Energy, Sustainability and the Environment
  • Organic Chemistry
  • Pharmacology
  • Materials Chemistry

The primary topics covered in Liu's body of work are:

  • Microbial Natural Products and Biosynthesis
  • Metalloenzymes and iron-sulfur proteins
  • Biochemical and Molecular Research
  • Carbohydrate Chemistry and Synthesis
  • Enzyme Structure and Function
  • CO2 Reduction Techniques and Catalysts
  • Metal-Catalyzed Oxygenation Mechanisms

Liu has contributed extensively to scientific literature, with frequent publications in the following venues:

  • Journal of the American Chemical Society
  • ACS Catalysis
  • The Cambridge Structural Database
  • Biochemistry
  • Angewandte Chemie International Edition

Recent peer-reviewed papers by Liu include:

  • S-Adenosylmethionine: more than just a methyl donor, 2023, Natural Product Reports
  • DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1, 2022, Cell Reports
  • Flavin-enabled reductive and oxidative epoxide ring opening reactions, 2022, Nature Communications
  • Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis, 2022, ACS Catalysis
  • Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A, 2020, Proceedings of the National Academy of Sciences

Liu collaborates regularly with several researchers, with frequent co-authors including:

  • Yu-Hsuan Lee
  • Mark W. Ruszczycky
  • Daan Ren
  • Ziyang Zheng
  • Po-Hsun Fan

Best Publications

  • A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity

    Yongquan Xue;Lishan Zhao;Hung Wen Liu;David H. Sherman

  • Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

    Christopher J. Thibodeaux;Charles E. Melançon;Hung-Wen Liu

  • Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

    Lishan Zhao;Wei Chen Chang;Youli Xiao;Hung Wen Liu

  • Unusual sugar biosynthesis and natural product glycodiversification

    Christopher J. Thibodeaux;Charles E. Melançon;Hung Wen Liu

  • Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

    Hung Wen Liu;Jon S. Thorson

  • Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

    Hak Joong Kim;Mark W. Ruszczycky;Sei Hyun Choi;Yung Nan Liu

  • Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic acid during its conversion to ethylene.

    Galen D. Peiser;Tsu-Tsuen Wang;Neil E. Hoffman;Shang Fa Yang

  • Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.

    Christopher J. Thibodeaux;Wei Chen Chang;Hung-Wen Liu

  • The diverse roles of flavin coenzymes - Nature's most versatile thespians

    Steven O. Mansoorabadi;Christopher J. Thibodeaux;Hung Wen Liu

  • Formation of unusual sugars: mechanistic studies and biosynthetic applications.

    Xuemei M. He;Hung-Wen Liu

  • Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications.

    Zhihua Tao;Peng Gao;Hung Wen Liu

  • Enoyl-CoA hydratase. reaction, mechanism, and inhibition

    Gautam Agnihotri;Hung-wen Liu

  • Reversal of the apparent regiospecificity of NAD(P)H-dependent hydride transfer: the properties of the difluoromethylene group, a carbonyl mimic.

    Caroline Leriche;Xuemei He;Cheng-Wei T. Chang;Hung-Wen Liu

  • Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae

    Yongquan Xue;Daniel Wilson;Lishan Zhao;Hung Wen Liu

  • Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

    Hua Zhang;Jess A. White-Phillip;Charles E. Melançon;Hyung-jin Kwon

  • GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

    Hak Joong Kim;Reid M. McCarty;Yasushi Ogasawara;Yung Nan Liu

  • Current development in isoprenoid precursor biosynthesis and regulation

    Wei chen Chang;Heng Song;Hung wen Liu;Pinghua Liu

  • Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme.

    Luke J. Higgins;Feng Yan;Pinghua Liu;Pinghua Liu;Hung-wen Liu

  • Novel enzymatic mechanisms in carbohydrate metabolism.

    Xuemei He;and Gautam Agnihotri;Hung-wen Liu

  • Natural [4 + 2]-Cyclases

    Byung-sun Jeon;Shao-An Wang;Mark W. Ruszczycky;Hung-wen Liu

  • Mechanistic study on the inactivation of general acyl-CoA dehydrogenase by a metabolite of hypoglycin A

    Ming Tain Lai;Li Da Liu;Hung Wen Liu

  • Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.

    Danny Yun;Mishtu Dey;Luke J. Higgins;Luke J. Higgins;Feng Yan

Frequent Co-Authors

Koji Nakanishi
Koji Nakanishi Columbia University
Zongbao K. Zhao
Zongbao K. Zhao Dalian Institute of Chemical Physics
David H. Sherman
David H. Sherman University of Michigan–Ann Arbor
Jon S. Thorson
Jon S. Thorson University of Kentucky
Christopher T. Walsh
Christopher T. Walsh Stanford University
Tomohisa Kuzuyama
Tomohisa Kuzuyama University of Tokyo
David H. Russell
David H. Russell Texas A&M University
John D. Lipscomb
John D. Lipscomb University of Minnesota
Xiaoyang Zhu
Xiaoyang Zhu Columbia University

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