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D-Index & Metrics

Chemistry

D-Index
68
Citations
14969
World Ranking
6604
National Ranking
1996

Biology and Biochemistry

D-Index
68
Citations
14993
World Ranking
7877
National Ranking
3575

Overview

Jon S. Thorson is a researcher affiliated with the University of Kentucky in the United States. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, with significant contributions also in medicine.

The main fields of study for Thorson include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these disciplines, their subfields of specialization cover:

  • Molecular Biology
  • Pharmacology
  • Organic Chemistry
  • Biotechnology
  • Oncology

Thorson's primary research topics feature:

  • Microbial Natural Products and Biosynthesis
  • Marine Sponges and Natural Products
  • Fungal Biology and Applications
  • Protein Degradation and Inhibitors
  • Chronic Lymphocytic Leukemia Research
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction

Frequent co-authors contributing to joint publications with Thorson include:

  • Khaled A. Shaaban
  • Larissa V. Ponomareva
  • Steven G. Van Lanen
  • Markos Leggas
  • Jürgen Rohr

Thorson has published notably in the following academic venues:

  • Journal of Natural Products
  • Frontiers in Microbiology
  • ACS Synthetic Biology
  • ACS Chemical Biology
  • Journal of the American Chemical Society

Recent publications by Thorson include:

  • Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia, 2021, Leukemia
  • Pyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis, 2020, Nature Chemical Biology
  • Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens, 2021, Frontiers in Microbiology
  • Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes, 2020, ACS Chemical Biology
  • Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities, 2021, Biotechnology Reports

Best Publications

  • Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

    Ute Galm;Martin H. Hager;Steven G. Van Lanen;Jianhua Ju

  • A comprehensive review of glycosylated bacterial natural products.

    Sherif I. Elshahawi;Khaled A. Shaaban;Madan K. Kharel;Jon S. Thorson

  • Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

    Mark W. Nowak;Patrick C. Kearney;Jeffrey R. Sampson;Margaret E. Saks

  • A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

    Emmanuel Zazopoulos;Kexue Huang;Alfredo Staffa;Wen Liu

  • Structure, activity, synthesis and biosynthesis of aryl-C-glycosides

    Tsion Bililign;Byron R. Griffith;Jon S. Thorson

  • The calicheamicin gene cluster and its iterative type I enediyne PKS.

    Joachim Ahlert;Erica Shepard;Natalia Lomovskaya;Emmanuel Zazopoulos

  • Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

    Hung Wen Liu;Jon S. Thorson

  • Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions

    Changsheng Zhang;Byron R. Griffith;Qiang Fu;Christoph Albermann

  • Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

    Joseph M. Langenhan;Noël R. Peters;Ilia A. Guzei;F. Michael Hoffmann

  • Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution

    Gavin J Williams;Changsheng Zhang;Jon S Thorson

  • Antibiotic optimization via in vitro glycorandomization.

    Xun Fu;Christoph Albermann;Jiqing Jiang;Jianchun Liao

  • Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.

    Richard W. Gantt;Pauline Peltier-Pain;Jon S. Thorson

  • Natures Carbohydrate Chemists The Enzymatic Glycosylation of Bioactive Bacterial Metabolites

    Jon S. Thorson;Thomas J. Hosted;Jiqing Jiang;John B. Biggins

  • Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

    Jon S. Thorson;Eric L. Sievers;Joachim Ahlert;Erica Shepard

  • Enzymatic tools for engineering natural product glycosylation.

    Sophie Blanchard;Jon S Thorson

  • Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

    Aram Chang;Shanteri Singh;George N Phillips;Jon S Thorson

  • 'Sweetening' natural products via glycorandomization.

    Byron R Griffith;Joseph M Langenhan;Jon S Thorson

  • Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides

    Heather C Losey;Jiqing Jiang;John B Biggins;Markus Oberthür

  • Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification.

    Joseph M. Langenhan;Byron R. Griffith;Jon S. Thorson

  • Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.

    William A. Barton;Jacob Lesniak;Jacob Lesniak;John B. Biggins;John B. Biggins;Philip D. Jeffrey;Philip D. Jeffrey

Frequent Co-Authors

George N. Phillips
George N. Phillips Rice University
Jürgen Rohr
Jürgen Rohr University of Kentucky
Andrew J. Morris
Andrew J. Morris University of Kentucky
James C. Hower
James C. Hower University of Kentucky
Chang-Guo Zhan
Chang-Guo Zhan University of Kentucky
Hung-wen Liu
Hung-wen Liu The University of Texas at Austin
Ben Shen
Ben Shen Scripps Research Institute
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Wen Liu
Wen Liu Chinese Academy of Sciences
Andreas Bechthold
Andreas Bechthold University of Freiburg

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